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Elevated level of wnt5a protein in localized prostate cancer tissue is associated with better outcome.

Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays an important role in cancer development and progression. Previous studies report that Wnt5a is upregulated in prostate cancer and suggested that Wnt5a affects migration and invasion of prostate tumor cell. This study aimed to evaluate the prognostic value of Wnt5a protein expression in prostate cancer tissue and its potent

A single-step competitive binding assay for mapping of single DNA molecules

Optical mapping of genomic DNA is of relevance for a plethora of applications such as scaffolding for sequencing and detection of structural variations as well as identification cif pathogens like bacteria and viruses. For future clinical applications it is desirable to have a fast and robust mapping method based on as few steps as possible. We here demonstrate a single-step method to obtain a DNA

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence o

Social Ontology and Social Cognition

The aim of this paper is to show that there is a reciprocal dependency relationship between social cognition and social ontology. It is argued that, on the one hand, the existence conditions of socially meaningful objects and of social groups are about subjects’ social cognitive processes and interactive patterns and, on the other hand, social cognitive processes and interactive patterns are modul

Högskolepedagogik som motstånd och anpassning i historia, nutid och framtid

Denna artikel är en reflektion över högskolepedagogikens historia, nutid och framtid. I den identifieras två strategier som kan ses som syftet med en högskolepedagogisk utbildning för universitetslärare: motstånd mot negativa konsekvenser av den oerhörda förändring som skett av universiteten de senaste decennierna, samt anpassning till en överlevnad och sökandet efter styrka i dessa förändringar.

Wavelengths, Energy Levels, Lifetimes, and Weighted Oscillator Strengths for the S VIII Spectrum

The weighted oscillator strengths (gf) and lifetimes for S VIII presented in this work were obtained by a multiconfigurational Hartree-Fock relativistic approach. In this calculation, the electrostatic energy parameters were optimized by a least-squares procedure in order to improve the adjustment to experimental energy levels. The values for gf and lifetimes were then calculated on the basis of t

Terrestrial export of highly bioavailable carbon from small boreal catchments in spring floods

1. We assessed the terrestrial export of organic carbon, which effectively supported aquatic bacterial production (BP), from small boreal catchments during spring flood. We analysed stream runoff from nine small catchments with different proportions of peat mires and coniferous forests by monitoring the dissolved organic carbon (DOC) flux in combination with conducting bacterial bioassays. 2. Mu

Bias-controlled friction of InAs nanowires on a silicon nitride layer studied by atomic force microscopy

By studying how nanowires lying on a surface bend when pushed by an atomic force microscopy tip we are able to measure the friction between them and the substrate. Here, we show how the friction between InAs nanowires and an insulating silicon nitride layer varies when a dc voltage is applied to the tip during manipulation. The bias charges the capacitor formed by the wire and the grounded silicon

The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on beta-cells

Background: Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). We have examined the effects of these putative mediators of whey's action on insulin secretion from isolated mouse Langerhans islets. Methods: Mouse p

Measurement of diffractive scattering of photons with large momentum transfer at HERA

The first measurement of diffractive scattering of quasi-real photons with large momentum transfer gamma p -> gamma Y, where Y is the proton dissociative system, is made using the H1 detector at HERA. The measurement is performed for initial photon virtualities Q(2) < 0.01 GeV2. Single differential cross sections are Measured as a function of W, the incident photon-proton centre of mass energy, an

Optimal shape of a cold-neutron triple-axis spectrometer

We have performed a McStas optimization of the primary spectrometer for a generic 40 m long, cold-neutron triple-axis spectrometer with a doubly focusing monochromator. The optimal design contains an elliptically focusing guide, a virtual source point before a low-grade PG monochromator, and non-equidistant focusing at the monochromator. The flux at 5 meV shows a gain factor 12 over the "classical

Time perspective and mental health continuum: What are the time perspective profiles of flourishing, moderately mentally healthy, and languishing individuals?

Time perspective (TP) refers to individuals’ ways of constructing, reconstructing, and relating the psychological concepts of past, present,and future, and provides individuals with a coherence of experiences over time. In the present study, the relationships among five TPs (past negative, past positive, present fatalistic, present hedonistic, and future) were studied in a student sample (N = 280)

A Virtual Sensor for Predicting Diesel Engine Emissions from Cylinder Pressure Data

Cylinder pressure sensors provide detailed information on the diesel engine combustion process. This paper presents a method to use cylinder-pressure data for prediction of engine emissions by exploiting data-mining techniques. The proposed method uses principal component analysis to reduce the dimension of the cylinder-pressure data, and a neural network to model the nonlinear relationship betwee

Water Sorption and Glass Transition of Pig Gastric Mucin Studied by QCM-D.

Hydration of films of pig gastric mucin was studied using a quartz crystal microbalance with dissipation monitoring (QCM-D) equipped with a humidity module. As a prerequisite, the water adsorption isotherm of a clean silica surface was determined. Atomic force microscopy was used to characterize the changes occurring on the silica surface after repeated sorption/desorption and cleaning cycles. The

Pictorial Primates: A Search for Iconic Abilities in Great Apes

Pictures and other iconic media are used extensively in psychological experiments on nonhuman primate perception, categorisation, etc. They are also used in everyday interaction with primates, and as pure entertainment. But in what ways do primates understand iconic artefacts? What implications do these different ways have for the conclusions we can draw from those studies on perception and catego

Two-particle Bose-Einstein correlations in pp collisions at [Formula: see text] 0.9 and 7 TeV measured with the ATLAS detector.

The paper presents studies of Bose-Einstein Correlations (BEC) for pairs of like-sign charged particles measured in the kinematic range [Formula: see text] 100 MeV and [Formula: see text] 2.5 in proton collisions at centre-of-mass energies of 0.9 and 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. The integrated luminosities are approximately 7 [Formula: see text]b[Formula: see te

(ii) Nerve injuries

A peripheral nerve can be injured in different ways, varying from a simple nerve compression, a complete transection or laceration and also as traction lesions such as brachial plexus injuries (including avulsion of spinal nerve roots). A thorough history and examination of the patient is crucial to make a correct diagnosis of the lesion, so that the correct treatment can be initiated immediately.