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Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study.
The collaborative learning methodology CORONET-Train: Implementation and guidance
The introduction of new methodologies into a software organization is a non-trivial problem because it usually requires the alteration of existing business and development processes and the change of habits and beliefs of software engineers and managers. This is particularly true for comprehensive methodologies that integrate e-learning and knowledge management. An example is the web-based collabo
Is there screwiness at the end of the QCD cascades?
We discuss what happens at the end of the QCD cascades. We show that, with just a few reasonable assumptions, the emission of soft gluons is constrained to produce an ordered field in the form of a helix. We describe how to modify the Lund fragmentation scheme in order to fragment such a field. Our modified fragmentation scheme yields results which are consistent with current experimental measurem
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
We analyzed a comprehensive set of single-nucleotide polymorphisms (SNPs) and length polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the autoimmune disease systemic lupus erythematosus (SLE) in 485 Swedish patients and 563 controls. We found 16 SNPs and two length polymorphisms that display association with SLE (P < 0.0005, OR > 1.4). Using a Bayesian mod
Subnormal operators with compact selfcommutator
If $S$ is a hyponormal operator, then Putnam's inequality gives an estimate on the norm of the self-commutator $[S^*,S]$, while the Berger-Shaw theorem gives (under appropriate cyclicity hypotheses) a corresponding estimate on the trace of $[S^*,S]$. Of course these results hold when $S$ is subnormal. In the subnormal setting, the author obtains useful estimates on the norm and essential norm of
Genetic structure of the diploid–polyploid fish Squalius alburnoides in southern Iberian basins Tejo and Guadiana, based on microsatellites
Several studies have demonstrated the hybrid origin of Squalius alburnoides, a complex of diploid, triploid and tetraploid fish, with Squalius pyrenaicus as the maternal ancestor and an Anaecypris hispanica-like species as the paternal ancestor. The aim of this study was to assess patterns of genetic diversity and similarity between sympatric forms of the different ploidy levels of S. alburnoides
Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y (12) receptor and is correlated with protein expression of P2Y (12).
Two ADP receptors have been identified on human platelets: P2Y(1) and P2Y(12). The P2Y(12) receptor blocker clopidogrel is widely used to reduce the risks in acute coronary syndromes, but, currently, there is no P2Y(1) blocker in clinical use. Evidence for variable responses to clopidogrel has been described in several reports. The mechanistic explanation for this phenomenon is not fully understoo
The Agenda-Shaping Powers of the EU Council Presidency
Existing literature is overwhelmingly sceptical about the capacity of the Council Presidency to shape the EU agenda. The Presidency's ability to promote private concerns is considered highly limited and, typically, the Presidency is depicted as a "responsabilité sans pouvior'. This article challenges the conventional wisdom on theoretical and empirical grounds. Theoretically, it develops a concept
Suicide-attempters having immunoglobulin G with affinity for doparnine in cerebrospinal fluid
Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (
Model process for separation based on unfolding and refolding of chymotrypsin inhibitor 2 in thermoseparating polymer two-phase systems
For the design of a new separation process based on unfolding and refolding of protein, the partitioning behaviour of proteins was studied in thermoseparating polymer two-phase systems with varying pH and temperature. Chymotrypsin inhibitor 2 (CI2), which unfolds reversibly in a simple two-state manner, was partitioned in an aqueous two-phase system (ATPS) composed of a random copolymer of ethylen
A decision support system improves the interpretation of myocardial perfusion imaging.
PURPOSE: The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS). METHODS: Seven physicians independently interpreted 97 MPS studies, first without and then with the advice of a DSS. Four physicians had long
Illness-related complaints in women with chronic widespread pain: importance of a contextual approach
The study, comprising 125 sick-listed women aged 25-64 (m = 46.9 years) with widespread chronic pain, aimed at evaluating biopsychosocial problems as perceived by these women, studying such problems within a contextual framework, relating the findings to sociodemographic and medical data. Musculoskeletal complaints, fatigue, inability to work, sleep disturbances and uncertainty about the future we
Prevalence and genetics of immotile-cilia syndrome and left-handedness
Immotile-cilia syndrome is characterized by severe respiratory distress from early infancy, and also often by situs inversus. The first description of the disease was based on just four persons, but reasons were given to suggest that the disorder may not be exceedingly rare. The purpose of the present study was to estimate just how rare or how common it is and to evaluate its association with situ
Can vector summation describe the orientation system of juvenile ospreys and honey buzzards? - An analysis of ring recoveries and satellite tracking
Juvenile bird migrants are generally believed to use a clock-and-compass migratory orientation strategy. According to such a strategy migrants accomplish their migration by flying a number of successive flight steps with direction and number of steps controlled by an endogenous programme. One powerful way of testing this is by comparing predictions from a model of such a strategy with observed pat
Ett nytt fackligt landskap bland tjänstemännen: Unionen och Sveriges Ingenjörer
Artikeln analyserar ur ett historiskt perspektiv två förbundssammanslagningar som under 2000-talet berört TCOs och SACOs största förbund inom privat sektor: bildandet av Unionen 1/1 2008 resp. Sveriges Ingenjörer 1/1 2007. Tidigare - mestadels aldrig fullföljda - sammanslagningsförsök som involverat Sif, HTF, Handels, Transport, SKTF, ST m fl fackförbund behandlas också, liksom den fram till HTFs
Thromboprophylaxis with dalteparin in medical patients: which patients benefit?
It is unclear whether thromboprophylaxis produces a consistent risk reduction in different subgroups of medical patients at risk from venous thromboembolism. We performed a retrospective, post hoc analysis of 3706 patients enrolled in the PREVENT study. Patients were at least 40 years old with an acute medical condition requiring hospitalization for at least 4 days and had no more than 3 days of i
Fractionation of delta N-15 and delta C-13 for Atlantic salmon and its intestinal cestode Eubothtium crassum
Stable isotopes of nitrogen (delta(15) N) and carbon (delta C-13) were measured for Atlantic salmon Salmo salar and their intestinal cestode, Eubothrium crassum, sharing the same diet. Atlantic salmon muscle tissues were enriched in N-15 and depleted in C-13 compared to their prey (sprat Sprattles sprattus sprattus) and their intestinal cestode. There was no significant difference in delta N-15 or
Preface: Neck pain and the decade of the bone and joint 2000-2010
Alzheimer's disease and the cerebellum: a morphologic study on neuronal and glial changes
Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lowe