The Human Rights Council received well the ‘protect, respect, remedy’ framework that the SRSG for business and human rights, John Ruggie, presented in 2008 and his mandate was renewed for another 3 years. The corporate responsibility to respect human rights is defined narrowly for abuses linked to business activities only. In the same time, the SRSG remarks that conduct in the form of both acts an

Osteoarthritis is a major cause of disability and early retirement. Yet we lack the means to diagnose the disease in its early stages or to monitor the effects of treatment on the target tissue, the joint cartilage. Neither can we identify the disease mechanisms at the tissue or cell level. Current research focuses on the use of markers of cartilage matrix metabolism in body fluids as a means to d

The close linkage between iron (Fe) and phosphorus (P) suggests that changes in Fe speciation may have a strong effect on the bioavailability of P. At the same time Fe speciation in natural oxic environments is known to be affected by the presence of organic matter (OM), pH and total Fe concentrations, thus these parameters should also influence the Fe-P interactions. The main objective of the pre

ABSTRACT: The aim of this article is to present arguments for an integrated empirical research on teaching and learning based on previous research and the phenomenographic research tradition. From 1970 and for some years after, the main focus in phenomenographic research was on students’ approaches to and understanding of subject matter. Later, based on Variation theory and in the form of Learning

Local, superficial damage was detected and localized on an 8 × 2-m concrete floor slab using a structural health monitoring system. A total of 30 piezoelectric transducers, placed in a grid, transmitted and received continuous ultrasonic waves that were measured using a lock-in amplifier. Tomography was used to create images from the measured amplitude and phase of the continuous waves between all

Subjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep problems with changes in brain and behaviour. This study aimed to investigate whether subjective reports of sleep problems in HD are associated with brain volume, neurocognitive decline, and neuropsychiatric symptoms. This retros

We have studied the nature of the S 2p → 4eg shape resonance in the SF6 molecule by performing two different experiments. Soft X-ray emission spectra measured at the 4eg shape resonance reveal features that do not originate from the S 2p-1 states. One of the features can be assigned to the 6a1g → S 2p transition. The 6a1g orbital, which is empty in the molecular ground state, can be populated eith

Mixotrophy is found in almost all classes of phytoplankton in a wide range of aquatic habitats ranging from oligotrophic to eutrophic marine and freshwater systems. Few studies have addressed how the nutritional status of the predator and/or the prey affects mixotrophic metabolism despite the realization that mixotrophy is important ecologically. Laboratory experiments were conducted to examine ch

The precursors, [ 35S]sulfate and [2- 3H]mannose, were used to study the biosynthesis of keratan sulfate and other oligosaccharides on proteoglycans isolated from Day 8 cultures of chick limb bud chondrocytes. After alkaline borohydride treatment, three fractions with sialic acid were separated by molecular sieve chromatography. The first contained keratan sulfate which was purified by digestion w

Chondrocytes isolated from the Swarm rat chondrosarcoma were incubated in culture with [1-3H]glucose for 30 min to 8 h. Labeled proteoglycans were isolated, treated with borohydride under alkaline conditions, and the three complex sugar structures purified: N- and O-linked oligosaccharides and chondroitin sulfate chains. The amount of incorporated radioactivity into each component sugar was analyz