Sökresultat
Filtrera
Filtyp
Din sökning på "*" gav 535696 sökträffar
Does a negative wealth shock affect your health? : Evidence from an episode of 'expropriation with partial compensation' in nineteenth-century South Africa
Mutant huntingtin expression in the hypothalamus promotes ventral striatal neuropathology
Huntington’s disease is a fatal neurodegenerative disorder caused by an expanded CAG triplet repeat in the huntingtin (HTT) gene. Previous research focused on neuropathology in the striatum and its association with a typical movement disorder. Direct effects of mutant HTT (mHTT) in the striatum may cause neuropathology, although non-cell autonomous effects have also been suggested. Important non-m
Machine learning for early prediction of acute myocardial infarction or death in acute chest pain patients using electrocardiogram and blood tests at presentation
Aims: In the present study, we aimed to evaluate the performance of machine learning (ML) models for identification of acute myocardial infarction (AMI) or death within 30 days among emergency department (ED) chest pain patients. Methods and results: Using data from 9519 consecutive ED chest pain patients, we created ML models based on logistic regression or artificial neural networks. Model input
Efficient nonlinear reduced order modeling for dynamic analysis of flat structures
In the present paper, strategies for reduced order modeling of geometrically nonlinear finite element models are investigated. Simulation-free, non-intrusive approaches are considered, which do not require access to the source code of a finite element program (e.g., proprietary knowledge). Our study focus on but is not restricted to flat structures. Reduction bases are generated using bending mode
Environmental Peacebuilding and the United Nations
High-resolution spectroscopic techniques for studying rare-earth ions in nanoparticles
Rare-earth doped nanoparticles can exhibit narrow optical and spin linewidths at low temperatures. These outstanding properties for nanomaterials make them attractive for quantum technologies based on optically addressable spins such as quantum memories and computers. Although accurate linewidth measurements have been reported using, for example, spectral hole burning or photon echo techniques, so
Making waves : A vision for digital water utilities
Digitalisation has developed over half a century and is one of the global trends defining society of today and future. Digitalisation is envisioned to help water utilities to become: i) community orientated and digitally integrated with customers and society; ii) digitally transformed end-to-end throughout the value-chain and interconnected between business units; iii) predictive & proactive,
A thermo-electro-mechanically coupled cohesive zone formulation for predicting interfacial damage
Material interfaces can occur at different material length scales. Understanding the properties and the behaviour of interfaces is of utmost importance because interfaces can significantly influence the effective constitutive response of the material under consideration. Based on the fundamentals of electro-mechanically coupled cohesive zone formulations for electrical conductors and on the associ
Dual or single antiplatelet therapy after coronary surgery for acute coronary syndrome (TACSI trial) : Rationale and design of an investigator-initiated, prospective, multinational, registry-based randomized clinical trial
The TACSI trial (ClinicalTrials.gov Identifier: NCT03560310) tests the hypothesis that 1-year treatment with dual antiplatelet therapy with acetylsalicylic acid (ASA) and ticagrelor is superior to only ASA after isolated coronary artery bypass grafting (CABG) in patients with acute coronary syndrome. The TACSI trial is an investor-initiated pragmatic, prospective, multinational, multicenter, open-
Bringing to light nuclear-mitochondrial insertions in the genomes of nocturnal predatory birds
Mito-nuclear insertions, or NUMTs, relate to genetic material of mitochondrial origin that have been transferred to the nuclear DNA molecule. The increasing amounts of genomic data currently being produced presents an opportunity to investigate this type of patterns in genome evolution of non-model organisms. Identifying NUMTs across a range of closely related taxa allows one to generalize pattern
Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
Regulatory T cells (T(reg)) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote T(reg) expansion. Here, we hypothesized that adjunctive rapamycin therapy might potentiate the ability of ex vivo expanded human T(reg) to inhibit vascular allograft rejection in a hum
Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection
Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) u
In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
Transplant arteriosclerosis is the hallmark of chronic allograft dysfunction (CAD) affecting transplanted organs in the long term. These fibroproliferative lesions lead to neointimal thickening of arteries in all transplanted allografts. Luminal narrowing then leads to graft ischemia and organ demise. To date, there are no known tolerance induction strategies that prevent transplant arterioscleros
Role of T cells in graft rejection and transplantation tolerance
Transplantation is the most effective treatment for end-stage organ failure, but organ survival is limited by immune rejection and the side effects of immunosuppressive regimens. T cells are central to the process of transplant rejection through allorecognition of foreign antigens leading to their activation, and the orchestration of an effector response that results in organ damage. Long-term tra
Regulatory T cells : hypes and limitations
PURPOSE OF REVIEW: In recent years there has been increased interest in understanding the physiology and function of regulatory T cells. In this review we focus on the characterization of regulatory T-cell subsets and their potential therapeutic use in organ transplantation.RECENT FINDINGS: Regulatory T cells can play an instrumental role in the establishment of operational tolerance to allografts
Remissyttrande: Domstolsverkets promemoria Begäran om författningsändring avseende ledighet för domare för att ha en annan anställning
The effect of spatial and temporal planning scale on the trade-off between the financial value and carbon storage in production forests
Background: Increasing carbon stock in standing forests is one of the proposed ways to mitigate climate change. However, in production forests, this typically would lead to reduced harvesting possibilities and thus reduced financial gain for the forest owners. The size of this reduction should depend on the chosen target level of the carbon stock as well as the required speed of accumulation. Furt
Subclinical atherosclerosis and risk factors in relation to autonomic indices in the general population
OBJECTIVE: Orthostatic hypotension and resting heart rate (RHR) are associated with cardiovascular disease (CVD). However, it is unknown how these factors relate to subclinical CVD. We examined the relationship between orthostatic blood pressure (BP) response, RHR and cardiovascular risk factors, including coronary artery calcification score (CACS) and arterial stiffness, in the general population
Positionering av människor i väg- och järnvägstunnlar i händelse av brand
The overall aim of the current project is to investigate the possibility of using people's mobile phones to locate people in a tunnel environment, both during normal operation and during an emergency. As part of the project, a technology for locating people based on Wi-Fi communication between access points in a tunnel and the user's mobile phone is investigated. To examine the precision of the lo