Objective Anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD) and their unaffected family members. The aim of this study was to establish the value of serological markers as predictors of UC and CD. Design Individuals who developed CD or UC were identifie

Popular Abstract in Undetermined 1971 förklarade president Richard Nixon, som så många amerikanska presidenter före honom, krig. Nixons fiende var dock något oortodox; Nixon förklarade krig mot cancer. I och med att senaten godkände ”National Cancer Act”, av pressen snabbt döpt till ”War on cancer”, hoppades Nixon att kunna utradera cancer med hjälp av kraftigt ökade anslag till cancerforskning koDespite recent advances in cancer treatment, truly innovative approaches are required to move beyond the modest benefits achieved to date. HAMLET is a human protein-lipid complex originally discovered in breast milk able to kill a wide range of tumour cells while leaving healthy, differentiated cells unaffected. The aim of this thesis was to identify mechanisms dictating HAMLET sensitivity and to

The reaction of 1,3-C6H4(CH2PCy2)(2) with anhydrous nickel(II) chloride in dry THF produces the non-cyclometallated dinuclear complex trans-[Ni2Cl4{cis-(Cy2PCH2)(2)C6H4}(2)]. The compound was characterised by H-1, P-31 and C-13 NMR spectroscopy and its solid state structure was determined by X-ray diffraction. An improved synthetic procedure of the aromatic pincer ligand 1,3-C6H4(CH2PCy2)(2) is re

Popular Abstract in Swedish Det traditionella jordbruket i nordvästra Europa har gynnat förekomsten av många arter under tusentals år och den snabba övergången till modernt jord- och skogsbruk har lett till försämrade förutsättningar för dessa arter. Både internationellt och nationellt finns strategier för att bevara biologisk mångfald. I Sverige är dessa strategier integrerade i miljömål med ansThis thesis explores the relationship between land-use and floristic diversity over the last three millennia in the uplands of southern Sweden. A quantitative approach based on high-resolution pollen data was applied, using the Landscape Reconstruction Algorithm (LRA), historical maps/aerial photographs, palynological richness and new ways to estimate past evenness at regional and local spatial sc

In this study the cutting tool temperature that develops during rough turning of hardened cold-work tool steel is modelled on the basis of experimental data. The data obtained from a series of thermocouples, placed on a PCBN insert, into an anvil, and into a toolholder, were used as the input for the model. An inverse problem was solved, where the heat fluxes and heat transfer coefficients were co

Using a new concept—the law of the limit to land productivity—this article builds a three (physical, economic, and institutional) worlds’ land-use model with inverse logics of different development stages in a time perspective: before, in, and after the population trap. This model extends the span of the Malthusian population model to history after the Industrial Revolution and makes static proper

Intractable conflicts are by definition difficult to resolve. This study ventures into the identity dynamics of those conflicts and argues that those identity aspects must be addressed in order to locate constituencies for change. Through the employment o theories of conflict transformation, identity and narrative, the dissertation forwards thoughts regarding the importance of inside actors formul

Disperse dyes, which are used for colouring synthetic textile fibres, are well-known contact sensitisers. To investigate the outcome of patch-testing with a textile dye mix (TDM) at 7 dermatology clinics in Sweden, a TDM tested at 2 concentrations was included into the baseline series during one year. The mix consisted of Disperse (D) Blue 35, D Yellow 3, D Orange 1 and 3, D Red 1 and 17, all 1.0%

Induced neurons (iNs) offer a novel source of human neurons that can be explored for applications of disease modelling, diagnostics, drug screening and cell replacement therapy. Here we present a protocol for highly efficient generation of functional iNs from fetal human fibroblasts, and also demonstrate the ability of these converted human iNs (hiNs) to survive transplantation and maintain their

Vascular endothelial growth factor (VEGF) was first described as an angiogenic agent, but has recently also been shown to exert various neurotrophic and neuroprotective effects in the nervous system. These effects of VEGF are mainly mediated by its receptor, VEGFR-2, which is also referred to as the fetal liver kinase receptor 1 (Flk-1). VEGF is up-regulated in neurons and glial cells after epilep

The adsorption and shear rheological behavior is studied of beta-lactoglobulin (BLG) alone and in mixtures with sodium dodecyl sulphate (SOS) at water/hexane and water/MCT interface. At a low ratio of SDS in the mixture, the adsorbed layer at the interface comprises mostly of protein-surfactant complexes while at a higher SDS/BLG mixing ratio the surfactant dominates at the interface and governs t

We performed a detailed study of the ratio of low-alpha to high-alpha stars in the Galactic halo as observed by the Gaia-ESO Survey. Using a sample of 381 metal-poor stars from the second internal data release, we found that the value of this ratio did not show evidence of systematic trends as a function of metallicity, surface gravity, Galactic latitude, Galactic longitude, height above the Galac

The aim of this thesis was to explore the impact of meniscal injury and meniscectomy on joint and muscle function, physical activity and perceived health in middle-age subjects and to evaluate the effect of a functional exercise program. Male and female post meniscectomy patients participated in Studies I-IV (n=45 in Studies I-III, n=99 in Study IV) and Study IV also included 94 controls. Outcome