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Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC

Aims: This study investigates the lobbying actors of the food and drink industry (FDI), their web lobbying arguments used in the sugar taxation debate and the tactics deployed when facing legislative restrictions on their products to curb the burden of non-communicable diseases in Europe. Methods: A stakeholder analysis was performed to identify the FDI’s actors lobbying against sugar taxation wit

Objectives We examined whether daily physical activity (PA) during compulsory school encourages children to be more physically active during the intervention and 4 years after termination of the programme. Methods This prospective controlled intervention study followed the same 124 children (81 children in an intervention group and 43 controls) aged 7.7±0.6 (mean±SD) during a 7-year PA interventio

BACKGROUND: Several studies have demonstrated a prognostic impact of tumor-infiltrating T lymphocytes and natural killer (NK) cells in esophageal and gastric adenocarcinoma, but whether these associations differ by the density of tumor-infiltrating immune cells of the B cell lineage remains largely unknown. RESULTS: High infiltration of any T and NK lymphocytes investigated was in general associat

In this study, 14 standard facial distances on 10 adult volunteers were measured directly with a caliper and indirectly on two-dimensional images using the 3dMDtrio system. Two raters performed the measurements with at least 1 week between rating sessions. The intra- and inter-rater reliabilities and agreement of the measurements were calculated using intra-class correlation coefficient (ICC), mea

Abstract A novel set of integrated procedures for quantification of fibroblast-rich stroma and vascular characteristics has recently been presented allowing discovery of novel perivascular and stromal biomarkers in colorectal, renal cell, and ovarian cancer. In the present study, data obtained through these procedures from clinically well-annotated collections of these three tumour types have been

Objectives In youth sports, musculoskeletal pain is often studied from the standpoint of sports injuries, but little is known about pain conditions in which athletes still participate. The aim was to study the frequency of pain and associations with maturity offset, health status and sports performance in 14-year-old sport school students. Methods Cross-sectional design. One hundred and seventy-ei

Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic modifications as well as the organization and architecture of chromatin h

We present an algorithm to rearrange the colour chains of dipole showers in the shower process according to the colour amplitudes of a simple matrix element. We implement the procedure in the dipole shower of Herwig and show comparisons to data.

Liposuction, which is a very effective treatment modality to reduce lymphedema, can be performed as soon as the pitting component had been corrected by a phase of initial compression (Figure 1). Just like after conservative treatment, the use of compression garments after liposuction is very important to maintain the outcome.Garments should be prescribed in such numbers so that the edema does not

The wide variety of physical phenomena, such as motion of objects, reaction among chemical substances, electricity flow in a circuit can be described by equations with quantities that vary along time.The rate at which a quantity is changing with respect to its independent variable (time), is represented by its derivative. Thus, these phenomena are modeled by equations with differential variables tAdaptive multistep methods have been widely used to solve initial value problems. These ordinary differential equations (ODEs) may arise from semi-discretization of time-dependent partial differential equations(PDEs) or may combine with some algebraic equations to represent a differential algebraic equations (DAEs).In this thesis we study the initialization of multistep methods and parametrize som

Revisiting the Laval case through a discourse analysis of how it has been portrayed in legal doctrine.

Already during the Romantic period, translation played a key role in the mediation of reform ideas from Britain to the Nordic countries, and many translators of texts aiming at social reform wished to instigate change in their home countries. The focus of the present article is on the way in which Henry Brougham’s programme for popular education, as presented in Practical Observations upon the EduDuring the Romantic period, translation played a key role in the mediation of reform ideas from Britain to the Nordic countries, and many translators of texts aiming at social reform wished to instigate change in their home countries. This article focuses on how Henry Brougham’s programme for popular education, as presented in Practical Observations upon the Education of the People (1825), was mad

A cluster-randomized controlled trial, WorkUp, was conducted for working-aged patients at risk of sick leave or on short-term sick leave due to acute/subacute neck and/or back pain in Sweden. The purpose of WorkUp was to facilitate participants to stay at work or in case of sick leave, return-to-work. The aim of this study was to study whether the WorkUp trial was cost- effective. Patients in the A cluster-randomized controlled trial, WorkUp, was conducted for working-aged patients at risk of sick leave or on short-term sick leave due to acute/subacute neck and/or back pain in Sweden. The purpose of WorkUp was to facilitate participants to stay at work or in case of sick leave, return-to-work. The aim of this study was to study whether the WorkUp trial was cost-effective. Patients in the i

Abstract Parasites that can infect multiple host species are considered to be host generalists with low host specificity. However, whether generalist parasites are better adapted to a subset of their host species remains unknown. To elucidate this possibility, we compared the variation in prevalence and infection intensity among host species of three generalist parasite lineages belonging to the m

Objective: To determine factors associated with orthopaedic surgeons’ decision to recommend total joint replacement (TJR) in people with knee and hip osteoarthritis (OA). Design: Cross-sectional study in eleven countries. For consecutive outpatients with definite hip or knee OA consulting an orthopaedic surgeon, the surgeon's indication of TJR was collected, as well as patients’ characteristics in

Transitioning to renewable energy is an imperative to help mitigate climate change, but such transitions are inevitably embedded in broader socio-ecological and political dynamics. Recent scholarship has focused on these more-than-technological dimensions of energy transitions to help understand their promises and drawbacks. This article contributes to this research agenda by highlighting the impo