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The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial

Granulocyte chemotactic protein 2 (GCP-2)/CXCL6 is a CXC chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. Through binding and activation of its receptors (CXCR1 and CXCR2), it exerts neutrophil-activating and angiogenic activities. Here we show that GCP-2/CXCL6 itself is antibacterial. Antibacterial activity against gram-positive and gram-negative pathog

PITX2 gain-of-function induced defects in mouse forelimb development.

BACKGROUND: Limb development and patterning originate from a complex interplay between the skeletal elements, tendons, and muscles of the limb. One of the genes involved in patterning of limb muscles is the homeobox transcription factor Pitx2 but its role in forelimb development is uncharacterized. Pitx2 is expressed in the majority of premature presumptive forelimb musculature at embryonic day 12

An analysis of the block error probability performance of iterative decoding

Asymptotic iterative decoding performance is analyzed for several classes of iteratively decodable codes when the block length of the codes N and the number of iterations I go to infinity. Three classes of codes are considered. These are Gallager's regular low-density parity-check (LDPC) codes, Tanner's generalized LDPC (GLDPC) codes, and the turbo codes due to Berrou et al. It is proved that ther

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Review of "Across the North Sea. Later Historical Archaeology in Britain and Denmark, c. 1500-2000 AD" (2012)

Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia.

BACKGROUND: Inflammation has been proposed to be important in the pathogenesis of diabetic retinopathy. An early feature of inflammation is the release of cytokines leading to increased expression of endothelial activation markers such as vascular cellular adhesion molecule-1 (VCAM-1). Here we investigated the impact of diabetes and dyslipidemia on VCAM-1 expression in mouse retinal vessels, as we

What Drives Exports? Empirical Evidence at the Firm Level

The aim of this thesis is to the understand how firms engage in exporting, particularly in consideration of three aspects—product type, past trade experience, and investments in innovation activities. It consists of one introductory chapter and three independent papers relating to determinants of firms’ exporting. Chapter 2 investigates the distance effect on the exporting of homogeneous and diff

Psykisk ohälsa, folkhälsa och medikalisering: har det egentligen någon betydelse vilket hälsobegrepp som används? [Poor mental health, public health and medicalization: is it of any significance which health concepts are used?].

The World Health Organization suggests mental ill health in terms of depres- sion soon to be the highest-ranking disease problem in the Western part of the world. However, some critics argue that the alarming reports on mental ill health have their ground in the methods of inquiry themselves and refer to medicalization as an important issue. The aim of this article is to explore and illuminate the