Popular Abstract in Swedish Bakgrund Alzheimers sjukdom (AD) är den vanligaste formen av demenssjukdom och svarar för ca 60 % av dessa patienter. Sjukdomen har en smygande debut och den sjukliga processen i hjärnan börjar troligen decennier innan den ger kliniska symptom som försämrat minne och organisationsförmåga, språksvårigheter, problem med tidsuppfattning och orientering. Även förmågan att uBackground Prospective longitudinal studies in Alzheimer's disease (AD) that include cholinesterase inhibitor (ChEI) treatment in routine clinical settings are scarce. The patients vary in severity of the disease, clinical course, rate of progression and response to treatment. Knowledge about the predicted course of the disease, sociodemographic and clinical factors affecting the outcome and the i

Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl-transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely

The far-infrared absorption spectra have been recorded for hydrogen-bonded complexes of water with methanol and t-butanol embedded in cryogenic neon matrices at 2.8 K. The partial isotopic substitution of individual subunits enabled by a dual inlet deposition procedure provides for the first time unambiguous assignments of the intermolecular high-frequency out-of-plane and low-frequency in-plane d

A two-stage system was investigated for anaerobic digestion (AD) of aerobically pre-treated sisal leaf decortication residue (SLDR) with regard to hydrolytic enzymes and biogas production. The system consisted of a solid-bed bioreactor for hydrolysis connected to methanogenic bioreactor packed with sisal fibre decortication residues (SFDR) as biofilm carriers. Some of the enzymes produced by micro

Akt (also known as PKB) is a survival kinase frequently up-regulated in cancer; three isoforms of Akt exist, and among them Akt1 and Akt2 are the most widely and highly expressed. They share the same structure and activation mechanism and have many overlapping functions; nevertheless isoform-specific roles and substrates have been reported, which are expected to rely on sequence diversities. In pa

New basis sets of the atomic natural orbital (ANO) type have been developed for the lanthanide atoms La-Lu. The ANOs have been obtained from the average density matrix of the ground and lowest excited states of the atom, the positive ions, and the atom in an electric field. Scalar relativistic effects are included through the use of a Douglas-Kroll-Hess Hamiltonian. Multiconfigurational wave funct

Vartannat år har Nordisk Lichenologisk Förening exkursion till något av medlemsländerna. I år gick exkursionen till Litauen och här får vi en rapport av Arne Thell.

Tubular ceramic membranes with many, small-diameter feed flow channels have the advantage of being less costly per unit membrane area. For this reason, membranes with many small channels are often favored over those with fewer larger channels. We have theoretically studied how the diameter of the feed flow channels influences the frictional pressure drop, the membrane performance (flux and retenti

The PHENIX experiment at RHIC has embarked on a broad range of upgrades to enhance its physics reach. One of the upgrades consists of a set of silicon vertex trackers that combine to cover the pseudorapidity range − 2.4 to 2.4. A description of the vertex detectors and some of their physics goals and capabilities will be given, as well as technology choices and results from prototype components.

Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT.

First, we explore the performance of nonword repetition (NWR) in children with specific language impairment (SLI) and typically developing children (TD) in order to investigate the accuracy of NWR as a clinical marker for SLI in Swedishspeaking school-age children. Second, we examine the relationship between NWR, family aggregation, and parental level of education in children with SLI. A sample of

This study explores the global regulative function of migration politics. Its main aim is to rethink migration politics through an engagement with the Foucauldian governmentality perspective, which focuses on the relation between government and thought. A secondary aim is to use this perspective to explore the global description of migration and migration politics which is emerging with the curren

Cadmium is a pollutant with multiple adverse health effects: renal dysfunction, osteoporosis and fractures, cancer, and probably cardiovascular disease. Some studies have reported associations between cadmium and impaired fasting glucose and diabetes. However, this relationship is controversial and there is a lack of longitudinal studies.

Johannesson A, Larsson G-U, Ramstrand N, Lauge-Pedersen H, Wagner P, Atroshi I: Outcomes of a standardized surgical and rehabilitation program in transtibial amputation for peripheral vascular disease: A prospective cohort study. OBJECTIVE:: To study the outcomes of a new surgical and rehabilitation program for initial unilateral transtibial amputation in patients with peripheral vascular disease.

Rising atmospheric carbon dioxide (CO2) may alleviate the toxicological impacts of concurrently rising tropospheric ozone (O-3) during the present century if higher CO2 is accompanied by lower stomatal conductance (g,), as assumed by many models. We investigated how elevated concentrations of CO2 and O-3, alone and in combination, affected the accumulated stomatal flux of O-3 (AFst) by canopies an

Hitherto unobserved long-lived massive particles with electric and/or colour charge are predicted by a range of theories which extend the Standard Model. In this Letter a search is performed at the ATLAS experiment for slow-moving charged particles produced in proton-proton collisions at 7 TeV centre-of-mass energy at the LHC, using a data-set corresponding to an integrated luminosity of 34 pb(-1)

The interaction between DNA and various cationic species, e. g. cationic surfactant (CS), has a broad biological and biotechnological significance. In the cell nucleus as well as in transfection formulations, other species, mainly zwitterionic lipids, are also present but their exact role needs elucidation. A closer investigation of the stability of structures formed as well as the molecular arran