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Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) in which oligodendrocytes, the CNS cells that stain most robustly for iron and myelin are the targets of injury. Metals are essential for normal CNS functioning, and metal imbalances have been linked to demyelination and neurodegeneration. Using a multidisciplinary approach involving synchro

Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus

Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). The glia–lymphati

ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma

Background: Hypoxia-inducible factor (HIF)-2α associates with poor outcome in neuroblastoma and glioblastoma, and gain-of-function mutations in the EPAS1 gene (encoding HIF-2α) have been reported in paragangliomas and pheochromocytomas. Specific targeting of a druggable hydrophobic pocket in the HIF-2α PAS-B domain with PT2385 have demonstrated promising clinical results for clear cell renal cell

From EU Citizens to Third Country Nationals: The Legacy of Polydor

This article considers the possible effects of ‘Brexit’ on British nationals who would no longer be EU citizens. Any Member State withdrawing from the Union is unlikely to cut all ties to the Internal Market. It is almost inevitable that a departing State would need to set up a bilateral or multilateral arrangement for the purpose of continuing to participate in the Internal Market. The analysis c

Third countries in EU agencies: Participation and influence

The EU’s practice of exporting its acquis to third countries is increasingly coupled with the integration of third countries in the work of the Union’s agencies. The reasons for including third countries vary, as do the forms and intensity of the cooperation. The aim of this study is to assess the possibilities for non-EU member states, in particular those that adopt and implement EU acquis in the

Adaptive Scatter Search to Solve the Minimum Connected Dominating Set Problem for Efficient Management of Wireless Networks

An efficient routing using a virtual backbone (VB) network is one of the most significant improvements in the wireless sensor network (WSN). One promising method for selecting this subset of network nodes is by finding the minimum connected dominating set (MCDS), where the searching space for finding a route is restricted to nodes in this MCDS. Thus, finding MCDS in a WSN provides a flexible low-c

How Iran’s Islamic Revolution Does, and Does Not, Influence Houthi Rule in Northern Yemen

at the Houthis are adherents of the Zaidi sect of Shia Islam has invited comparisons of the movement’s actions to the Iranian regime and the establishment of the Islamic republic following the fall of the monarchy in Tehran in 1979. Some Houthi adversaries have gone as far as alleging that the Houthis have converted to Twelver Shiism, seek to remodel Yemen along Iranian Twelver lines and to become

Inconsistencies in repeated refugee status decisions

Consistency in civil servant decisions is paramount to upholding judicial equality for citizens and individuals seeking safety through governmental intervention. We investigated refugee status decisions made by a sample of civil servants at the Swedish Migration Agency. We hypothesized, based on the emotional demands such decisions bring with them, that participants would exhibit a compassion fade

Danmarks teaterkarta ritas om

Rikard Loman skriver om var dansk teater befinner sig idag och vart den är på väg. Artikel om dansk samtidsteater utifrån intervju med teaterkritikern Anne Middelboe Christensen.