WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6-RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non-haematopoietic cells. However, its physiological function has been

The preparation of a polymer carrier for a boron delivery agent is presented through a combination of experimental and computational studies. A dodecahydro-closo-dodecaborate (B12H12)2– (B12) anion was used as a model boron-containing agent due to its high boron content. Quaternized poly(2-vinyl pyridine)-b-poly(ethylene oxide) (QP2VP-b-PEO) was chosen as a model neutral–cationic block copolymer t

Kan Bogong fjärilar dofta sig till en säker plats? Att komma hem från en lång semester och lägger sig i sin egen säng, känna doften av ens egna kudde och lägenhet ger en känsla av säkerhet. Det är en doft av hemma, av trygghet som vi känner igen. Är det möjligt att få samma upplevelse med en doft man aldrig känt förut? Så kan det vara för Bogong fjärilen (Agrotis infusa). De är nattaktiva fjärilaThe Bogong moth Agrotis infusa is a long-distance nocturnal migrant whose navigational ability still remains only partly understood. They travel up to a thousand kilometres to the Australian Alps where they seek out the shelter of isolated cool alpine caves, thereby escaping the approaching summer heat of their breeding grounds. Once in the caves, they enter a state of dormancy over the coming sum

Cardiovascular diseases are the leading cause of death worldwide, increasing yearly. However, many abnormalities in heart cycles can be discovered and treated years before the onset of diseases. But in most societies, regular health checkups are a concept reserved for cars, not humans. In order to save lives, our healthcare systems must adopt a preventative rather than a reactive approach. To that

Invasive alien species threaten biodiversity with domestic gardens acting as a major pathway for the introduction of alien species. Even though the Nordic region is not currently a hotspot for biological invasions, the number of invasions in the Nordic area has been predicted to increase due to climate change. Given a time lag between introduction and invasion, many non-invasive horticultural alie

We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two

Purpose: Tru-cut biopsy is a minimally invasive technique used to obtain tissue samples for the diagnosis of tumors, especially in patients where primary surgery is not indicated. The aim of this study was to assess the adequacy, accuracy and safety of the tru-cut biopsy for diagnosis in gynecological cancer.Methods: A retrospective population-based review of 328 biopsies was conducted. The indica

Frost formation in heat exchangers is an often accruing issue in cold climates. The aim of the project is to calculate the risk of frost formation in different Swedish cities by modeling vapor and frost behavior in heat exchangers.

The purpose of this thesis was to investigate how probit functions have changed based on research that has been conducted by RIVM in the Netherlands, and to investigate how the calculated risk evaluation changes when using new values derived in QRAs conducted in Sweden. The goal was to quantify any differences that might occur due to the changes in probit functions. To conduct this thesis a survey

OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years.RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young (TEDDY) study, annual assessment of activity using accelerometry was conducted from age 5 years. Time-to-ev

OBJECTIVE: To investigate the evolution of nailfold capillary density in patients with systemic sclerosis (SSc) in relation to immunosupressive treatment and autoantibodies.METHODS: Prospective study cohort. Consecutive newly diagnosed SSc patients were included into this study who, in a retrospective review, had at least 2 nailfold capillary microscopy (NCM) measurements performed during the firs

Monolithic heterogeneous integration of III-V semiconductors with the contemporary Si Complementary Metal Oxide Semiconductor (CMOS) technology has instigated a wide range of possibilities and functionalities in the semiconductor industry, in the field of digital circuits, optical sensors, light emitters, and high-frequency communication devices. However, the integration of III-V semiconductors is

Ground-level fine particulate matter (PM2.5) and ozone (O3) are air pollutants that can pose severe health risks. Surface PM2.5 and O3 concentrations can be monitored from satellites, but most retrieval methods retrieve PM2.5 or O3 separately and disregard the shared information between the two air pollutants, for example due to common emission sources. Using surface observations across China span

I det här projektet söks en balans mellan den högproduktiva jordbruksmarken och de boendemiljöer som existerar sida vid sida i södra Skåne. Projektet fokuserar på byn Grönby i utkanten av Trelleborgs kommun som en slags testbädd. I södra Skåne är många byar likt Grönby omgärdade av ett landskap starkt präglat av ett storskaligt jordbruk. Här återfinns den allemansrättsliga marken fragmenterad och

Syftet med denna uppsats är att undersöka varför användningen av så kallade svansförråd (där avdelningar delar med sig av överblivna läkemedel) på sjukhusen i Malmö och Lund inte fungerar optimalt trots att en rutin för detta existerar, och även vilka förändringar som kan implementeras för att öka användningen av förrådet. I uppsatsen är perspektivet att svansförrådet är en tjänst som personalen k

AIM: To study the association between within-person changes in patient-reported outcomes (PROMs) and wish for joint surgery during participation in a digital first-line intervention comprising exercise and education for knee/hip osteoarthritis (OA).METHODS: Retrospective observational registry study. Participants enrolled between 01/06/2018 and 30/10/2021 with follow-up data at 3 months (n=13,961)

Bakgrund: Aktivitetsbalans syftar till individers upplevelser av variation av aktiviteter i vardagen. Avsaknad av variation på aktiviteter kan leda till minskade upplevelser av aktivitetsbalans. Betalt arbete kan leda till att struktur, rutin och identitet formas i vardagen, samt kan motsatt leda till stressrelaterad psykisk ohälsa utifrån negativa faktorer på arbetsplatsen. Syfte: Studiens syfte