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Samhällsutveckling innebär nya förutsättningar för stora byggprojekt

Inte sällan beskrivs byggbranschen som konservativ och motvillig till förändringar, både av folk i branschen, av forskare samt av folk i allmänhet. Likväl har byggbranschen under årens lopp genomgått ett antal förändringar, ofta som reaktioner på nya förutsättningar skapade av förändringar i det omgivande samhället. Den här artikeln redovisar hur ett antal projektledare i stora byggprojekt uppfatt

The benefits and drawbacks of home oxygen therapy for COPD : what’s next?

Introduction: Home oxygen therapy is one of the few interventions that can improve survival in patients with chronic obstructive pulmonary disease (COPD) when administered appropriately, although it may cause side effects and be an unnecessary burden for some patients. Areas covered: This narrative review summarizes the current literature on the assessment of hypoxemia, different types of home oxy

Challenges in the engineering design, manufacture, and testing of polymer gears

Polymer gears are becoming more and more interesting parts of various machines; they are used in ever-more-demanding operating conditions. Due to their good mechanical properties, lightweight, and low noise during operation, they tend to substitute metallic gears in some traditional applications, and they also enter new applications such as e-bikes. A reliable design of polymer gears remains, to d

RF Characterization of Ferroelectric MOS Capacitors

The high-frequency capacitive and switching response of ferroelectric Hf0.5Zr0.5O2 (HZO) is investigated on scaled ferroelectric metal-oxide-semiconductor III-V capacitors. Spanning over six orders of magnitude, the measured frequency response allows for accurate modeling of the capacitance-frequency dispersion. The steady-state ferroelectric behavior is retained even in the mm-wave frequency rang

Climate-related loss and damage in contexts of agrarian change : differentiated sense of loss from extreme weather events in northeast Cambodia

The uneven burden of climate-related losses and damages and its implications for equity and social justice are receiving growing attention in science and policy. Smallholder farmers, indigenous groups, and ethnic minorities are often identified as particularly vulnerable and likely to experience a greater burden of climate-related loss and damage. However, limited attention has been paid to experi

Breathing techniques to reduce symptoms in people with serious respiratory illness : a systematic review

Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (technique

The EUropeanisation of Research Infrastructure Policy

Political interest in Research Infrastructures on a European scale has been a new phenomenon, marked in the early 2000s with the launch of the Lisbon Strategy and the European Research Area. European Research Infrastructure policy then developed through, first, the strategic incorporation of incumbents through new modes of coordination; second, the European Commission’s emphasis of joint responsib

Hypoxia-induced complement component 3 promotes aggressive tumor growth in the glioblastoma microenvironment

Glioblastoma (GBM) is the most aggressive form of glioma with a high rate of relapse despite intensive treatment. Tumor recurrence is tightly linked to radio-resistance, which in turn is associated with hypoxia. Here, we discovered a strong link between hypoxia and local complement signaling using publicly available bulk, single-cell, and spatially resolved transcriptomic data from patients with G

Opioids for the palliation of symptoms in people with serious respiratory illness : a systematic review and meta-analysis

Background People living with serious respiratory illness experience a high burden of distressing symptoms. Although opioids are prescribed for symptom management, they generate adverse events, and their benefits are unclear. Methods We examined the efficacy and safety of opioids for symptom management in people with serious respiratory illness. Embase, MEDLINE and the Cochrane Central Register of

How does dyslexia impact second language acquisition? : Insights from a questionnaire study with Italian and German learners of L2 English

This study compares the self-perception of first (L1) and second (L2) language competence and dyslexia awareness in two groups of dyslexic students, one German and one Italian, learning English as a second language. Based on a survey, we investigate the relationship between students’ self-perception of their L1 and L2 competence, and how perceived L1 competence, L2 learning motivation, time of dys

Sevuparin strongly reduces hepcidin expression in cells, mice, and healthy human volunteers

Hepcidin is an essential regulator of systemic iron availability mediating both iron uptake from the diet and its release from body stores. Abnormally high hepcidin levels resulting from inflammation in chronic diseases cause iron restriction with the onset of anemia. Restoring physiological levels of hepcidin could contribute to ameliorating anemia in these patients. Heparin derivatives are known

A Deep Learning Biomimetic Milky Way Compass

Moving in straight lines is a behaviour that enables organisms to search for food, move away from threats, and ultimately seek suitable environments in which to survive and reproduce. This study explores a vision-based technique for detecting a change in heading direction using the Milky Way (MW), one of the navigational cues that are known to be used by night-active insects. An algorithm is propo

MHC Class II Supertypes Affect Survival and Lifetime Reproductive Success in a Migratory Songbird

The major histocompatibility complex (MHC) plays a critical role in the immune response against pathogens. Its high polymorphism is thought to be mainly the consequence of host-pathogen co-evolution, but elucidating the mechanism(s) driving MHC evolution remains challenging for natural populations. We investigated the diversity of MHC class II genes in a wild population of pied flycatchers Ficedul

Iridescent.Achromatic.Translucent (e. 113) for chamber orchestra

From vision to sound. In this piece I was interested to transfer special properties of color into sound. This transference occurred in two ways: 1) Timbre as representing some color property; 2) Sound sequences/gestures as representing some color property.These transferences are metaphorical and inspirational, not systematic nor literal in any sense.Some of these special properties include:ACHROMA

Defining new reference intervals for serum free light chains in individuals with chronic kidney disease : Results of the iStopMM study

Serum free light chain (FLC) concentration is greatly affected by kidney function. Using a large prospective population-based cohort, we aimed to establish a reference interval for FLCs in persons with chronic kidney disease (CKD). A total of 75422 participants of the iStopMM study were screened with serum FLC, serum protein electrophoresis and immunofixation. Estimated glomerular filtration rate