In this symposium piece, I reply to the diverse and wide-ranging set of objections to my book (The Open Future: Why Future Contingents are All False) set forth by MacFarlane, Green, Wasserman, and Bigg & Miller.

Aims/hypothesis: Some studies find an increased risk of type 1 diabetes in children exposed to antibiotics. We investigated if exposure to antibiotics increases the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes. Methods: We used data from a Swedish case–control study (Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes [ESTRID]: LADA, n=597; type 2 diabetes

Rieger syndrome is an autosomal dominant human disorder affecting eye, tooth and umbilical development, andwhose primary morbidity is the 50% occurrence of glaucoma in affected individuals. The identification of etiologicmutations in the PITX2 gene and its encoded protein, solurshin, inspired the development of a transgenic animal thatmight serve as a model for this disorder. In addition, the more

The Bell-state measurement (BSM) is the projection of two qubits onto four orthogonal maximally entangled states. Here we first propose how to appropriately define more general BSMs, which have more than four possible outcomes, and then study whether they exist in quantum theory. We observe that nonprojective BSMs can be defined in a systematic way in terms of equiangular tight frames of maximally

Background and Non–HDL-C provides an estimate of lipid-associated risk and is a secondary treatment target after myocardial infarction Aims (MI). The aim was to study the relationship between non–HDL-C levels after MI and risk of adverse outcomes. Methods From the SWEDEHEART registry, 56 262 patients with MI were included. Outcomes were major adverse cardiovascular event (MACE: death, MI, and isch

Gen Z’s interest in ethical consumption, including tourism, is growing in response to pressing global challenges. However, there is limited research on the constraints tied to the ethical travel decisions of this young cohort of travelers. This qualitative study, grounded in the theory of constraints and ethical consumerism literature, addresses this gap. The findings reveal multi-layered and inte

Background and Objectives Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkersmay outperformone another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortic

This chapter lays the theoretical foundations of long-run economic growth. After providing an overview of the three fundamental regimes that have characterized the process of development over the course of human history on the basis of the seminal work of Galor and Weil (Am Econ Rev 90:806-828, 2000), we review existing theories offering explanations of the different stages of development. In part

Against the backdrop of tension between China and the United States, both South Korea and Europe are keen to find ways to diversify their R&D partners.

ABSTRACT This dissertation focuses on Sweden’s involvement in applying EU anti-dumping measures within the framework of its WTO commitments. Laying emphasis on the dilemma of liberal trade policy evident in Sweden on one hand and safeguarding its Indigenous industries from unfair competition on the other hand, this research seeks to unravel how this country fulfills its obligations to the EU and t

Objective: To assess the association between achievement of prostate-specific antigen (PSA) levels ≤0.2 ng/mL (henceforth ‘ultralow’) and clinical outcomes in patients in the ‘Targeted Investigational Treatment Analysis of Novel Anti-androgen’ (TITAN) study (ClinicalTrials.gov Identifier NCT02489318) with metastatic castration-sensitive prostate cancer (mCSPC). Patients and Methods: Patients in th

As part of the group show at Quartier am Hafen in Cologne the group show entitled 'Carried Landscapes' was about places of personal significance. plan b showed a print of all of their GPS traces to date.

CysK1 and CysK2 are two members of the cysteine/S-sulfocysteine synthase family in Mycobacterium tuberculosis, responsible for the de novo biosynthesis of L-cysteine, which is subsequently used as a building block for mycothiol. This metabolite is the first line defense of this pathogen against reactive oxygen and nitrogen species released by host macrophages after phagocytosis. In a previous medi

The Mosul Dam, one of Iraq’s most significant infrastructural projects, has been the subject of extensive debate and scrutiny,often overshadowed by negative narratives concerning its safety and environmental impact. These narratives overlook the dam’s significant function in creating food and energy and fostering local, regional, and global water cooperation. This article seeks to provide a compre

The accumulation of amyloid fibrils from the protein 𝛼-synuclein is a pathological hallmark of Parkinson´s disease. 𝛼-synuclein is a highly polar protein with a remarkable primary structure that can be divided into three regions: the slightly basic N-terminal region, a central hydrophobic region, and a highly acidic C-terminal tail. The C-terminal tail is of specific focus in this thesis. A chan

The NMDA receptors are natural glutamate binders that play critical roles in the function of the central nervous system, with their dysfunction implicated in serious psychiatric disorders and neurodegenerative conditions. Understanding their roles in the brain and developing treatments will benefit from the existence of small molecules specifically targeting different NMDA receptor subtypes. This

The Rieger syndrome, an autosomal dominant disorder involving ocular, dental, and umbilical defects is caused bymutations in PITX2, a Bicoid type homeobox protein. Moreover, Pitx2 is involved in the Nodal/Sonic hedgehogpathway that determines left/right polarity. Mouse Pitx2 mRNA is expressed in eye, tooth and umbilicus consistent withthe human Riegers phenotype. It is also asymmetrically expresse