The arrival of new genetic technologies that allow efficient examination of the whole human genome (microarray, next-generation sequencing) will impact upon both laboratories (cytogenetic and molecular genetics in the first instance) and clinical/medical genetic services. The interpretation of analytical results in terms of their clinical relevance and the predicted health status poses a challenge

A tax litigation concerning the value of non-traded financial instruments is impregnated by uncertainty. The aim of this paper is to study how uncertainty inherent in financial valuation models is discursively and rhetorically handled and constructed by the litigating parties as well as the court. A discourse analysis guided by the notion of hedging is conducted on The Swedish Tax Agency v. PwC (2A tax litigation concerning the value of nontraded financial instruments is impregnated by uncertainty. The aim of this paper is to study how uncertainty inherent in financial valuation models is discursively and rhetorically handled and constructed by the litigating parties aswell as the court. A discourse analysis guided by the notion of hedging is conducted on The Swedish Tax Agency v. PwC (201

BACKGROUND: Machine learning (ML) is an emerging tool for predicting need of end-of-life discussion and palliative care, by using mortality as a proxy. But deaths, unforeseen by emergency physicians at time of the emergency department (ED) visit, might have a weaker association with the ED visit.OBJECTIVES: To develop an ML algorithm that predicts unsurprising deaths within 30 days after ED discha

The production of a macroporous hydrogel column, known as cryogel, has been scaled up (up to 150 mL) in this work for the purification of human hemoglobin from non-clarified bacterial homogenates. Composite cryogels were synthesized in the presence of adult hemoglobin (HbA) to form a molecularly imprinted polymer (MIP)network where the affinity sites for the targeted molecule were placed directly

ObjectivesJoint replacement due to end-stage OA has been linked to incidence of several cancers. We aimed to estimate the association between newly diagnosed knee and hip OA and incidence of nine common cancer types.MethodsWe identified persons with incident knee or hip OA, aged ≥40 years, between 2009 and 2015 in the SIDIAP database in Catalonia, Spain. We matched up to three OA-free controls on

Mapping and monitoring the spatio-temporal variations of the Surface Urban Heat Island (SUHI) and thermal comfort of metropolitan areas are vital to obtaining the necessary information about the environmental conditions and promoting sustainable cities. As the most populated city of Iran, Tehran has experienced considerable population growth and Land Cover/Land Use (LULC) changes in the last decad

Is there a variation in facial ideals depending on ethnic background that affects judgements of outcome in orthognathic surgery? How does the evaluation correlate with patient-reported outcome measures? Two evaluation panels, Singaporean and Swedish, judged photographs of patients undergoing orthognathic surgery taken before and after operation. Improvement in facial aesthetics was calculated betw

The paper discusses what kind of truth bearer, or truth-ascription, a deflationist should take as primary. I first present number of arguments against a sententialist view. I then present a deflationary theory which takes propositions as primary, and try to show that it deals neatly with a wide range of linguistic data. Next, I consider both the view that there is no primary truth bearer, and the

I here respond to Pietro Salis’s objections against my original critique of the Prosentential Theory of Truth (PT). In addition, I clarify some points regarding the relationship between anaphoric relationships and “general semantic notions” like “equivalence”, “consequence”, and “sameness of content”, and make some further points about (PT)’s ability gto explain pragmatic and expressive features o

BACKGROUND: Sodium-glucose co-transporter (SGLT) inhibitors reduce cardiovascular outcomes including mortality in several populations; however, their effect on atrial fibrillation/flutter (AF) remains unclear. Our objective was to determine whether SGLT inhibitors reduce AF and whether a history of AF modifies the effect of SGLT inhibitors on the composite of heart failure hospitalization or cardi

The effects of climate change, whether they be via slow- or rapid-onset events such as extreme events, are inflicting devastating losses and damage on communities around the world, with the most vulnerable affected the most. Although the negative impacts of climate change and the concept of loss and damage are included in international conventions, such as the United Nations Warsaw International M

Glyoxalase I (GlxI) is a member of the glyoxalasesystem, which is important in cell detoxification and convertshemithioacetals of methylglyoxal (a cytotoxic byproduct of sugarmetabolism that may react with DNA or proteins and introducenucleic acid strand breaks, elevated mutation frequencies, andstructural or functional changes of the proteins) and glutathioneinto D-lactate. GlxI accepts both the

Heat generation in CFRP (carbon fibre reinforced plastic) with electromagnetic induction can result in several benefits to manufacturing and production. However, during induction heating of anisotropic materials such as CFRP, the temperature distribution depends on electrical and thermal conductivity in different directions. This article presents a numerical model for computing the temperature dis

Modes of climate variability affect global and regional climates on different spatio-temporal scales, and they have important impacts on human activities and ecosystems. As these modes are a useful tool for simplifying the understanding of the climate system, it is crucial that we gain improved knowledge of their long-term past evolution and interactions over time to contextualise their present an

Despite a few reports of photoluminescent and strongly photo-oxidizing transition metal complexes with a d5 electronic configuration, the photophysics and photochemistry of this class of transition metal complexes have largely remained unexplored. Recent investigations of earth-abundant iron(III) N-heterocyclic carbene (NHC) complexes have demonstrated promising photophysical and photochemical pro

Almost any conversation about Historical International Relations (IR) appears to be, at least implicitly, always already about Europe. The geographical and intellectual centrality of Europe shapes the way in which historically oriented work in IR operates. Paradoxically, despite a long and powerful lineage of disciplinary Eurocentrism, Europe has only rarely emerged as a conceptual focal point of

In the media and communications field, research investigating the digital media engagements of very young children at home has largely been restricted to survey methods relying on parental self-reports. Recognizing that qualitative approaches can provide insights in families’ practices, values, and attitudes, we argue for the fruitfulness of an ethnographic perspective, drawing on three cases from

In order to study the characteristics of 3D gas-liquid interfaces, flow pattern transitions, and void fraction in mini tubes, virtual multi-vision experiments and numerical simulations are conducted in a 5.16 mm horizontal tube with air as the dispersed phase and water as the continuous phase. Air and water flow velocities range from 0.024 to 12.330 m/s and from 0.039 to 0.942 m/s, respectively. A