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Extendible and Efficient Python Framework for Solving Evolution Equations with Stabilized Discontinuous Galerkin Methods

This paper discusses a Python interface for the recently published Dune-Fem-DG module which provides highly efficient implementations of the discontinuous Galerkin (DG) method for solving a wide range of nonlinear partial differential equations (PDEs). Although the C++ interfaces of Dune-Fem-DG are highly flexible and customizable, a solid knowledge of C++ is necessary to make use of this powerful

A Novel Microparticle Based Formulation for Topical Delivery of FOL-005, a Small Peptide

Although many therapeutically active peptides and proteins have been developed there is a lack of topical pharmaceutical products on the market containing these sensitive molecules. The main reasons may be lack of stability and a limitation of larger molecules to penetrate into the skin. In this study we investigated the possibility to develop a peptide formulation which enables follicular permeat

LAG3 Regulates T Cell Activation and Plaque Infiltration in Atherosclerotic Mice

Background: The immune checkpoint receptor lymphocyte-activation gene 3 (LAG3) is a new target for immune checkpoint blockade (ICB), but the effects of LAG3 on atherosclerosis are not known. Objectives: The aim of the study was to evaluate the role of LAG3 on plaque inflammation using murine hypercholesterolemic models of atherosclerosis. Methods: To study the role of LAG3 in atherosclerosis, we i

A review of research into tourism and climate change - Launching the annals of tourism research curated collection on tourism and climate change

The tourism sector declared a climate emergency in 2020. It is against this background that this Curated Collection on Climate Change and Tourism is launched. A bibliometric analysis of 1290 articles reviews the 35-year development of climate change and tourism scholarship, including major research themes, key knowledge gaps, and our capacity to deliver the enormous knowledge requirements for an e

Thermal performance in latticework ducts with various endwall shapes for aero-craft turbine cooling

The latticework duct plays an important role in turbine blade cooling for aircraft engines. The present numerical research provided information about the thermal performance in latticework ducts with different endwall shapes. Each latticework duct analyzed in this study had a crossing angle of 90° and 11 sub channels on both the two sides of the endwall. A numerical investigation was conducted at

Clinical, demographic and theory-derived maintaining factors as moderators of treatment outcome in internet-delivered cognitive behavioural therapy for children and adolescents with social anxiety disorder

Internet-delivered cognitive behavioural therapy (ICBT) is an efficacious treatment for social anxiety disorder (SAD) in youth. However, we have limited knowledge about patient characteristics that may be associated with better (or worse) treatment outcome. Particularly concerning factors suggested to be involved in the maintenance of SAD (e.g., anticipatory anxiety and post-event processing). The

Dyadic diagonalization of positive definite band matrices and efficient B-spline orthogonalization

A dyadic algorithm for diagonalizing an arbitrary positive definite band matrix, referred to as a band Gramian, is obtained to efficiently orthogonalize the B-splines. The algorithm can be also used as a fast inversion method for a band Gramian characterized by remarkable sparsity of the diagonalizing matrix. There are two versions of the algorithm: the first one is more efficient and is applicabl

Monitoring Spatial-Temporal Variations of Lake Level in Western China Using ICESat-1 and CryoSat-2 Satellite Altimetry

The lakes in the arid or semi-arid regions of western China are more sensitive to climate changes, and lake levels are considered as a direct indicator of regional climate variability. In this study, we combined satellite altimetry data from ICESat-1 with a smaller footprint and higher accuracy (compared to radar altimetry) and CryoSat-2 with a higher resolution in the along-track direction to mon

Short-acting β2-agonist use and asthma exacerbations in Swedish children : A SABINA Junior study

Background: In adults and adolescents with asthma, use of ≥3 short-acting β2-agonist (SABA) canisters/year is associated with increased exacerbation risk. Whether this association is present in younger children remains unknown. In this SABA use IN Asthma (SABINA) Junior study, we assessed the association of SABA collection with exacerbation risk in the general Swedish pediatric asthma population.

Perceived Consequences of Post-COVID-19 and Factors Associated with Low Life Satisfaction

A significant number of individuals experience post-COVID-19 symptoms, but knowledge of perceived consequences and life satisfaction is lacking. Here, we investigate perceived consequences regarding everyday life, health, physical activity and work post-COVID-19 and factors associated with low life satisfaction. A total of 766 people (mean age 48; 672 women) experiencing post-COVID-19 symptoms at

Simplex Lattice Design and X-ray Diffraction for Analysis of Soil Structure : A Case of Cement-Stabilised Compacted Tills Reinforced with Steel Slag and Slaked Lime

Evaluating the structure of soil prior to building construction is valuable in a large variety of geotechnical and civil engineering applications. To built an effective framework for assessing the strength of the stabilised soil, the presented workflow includes a complex approach of simplex lattice design and X-ray diffraction for the analysis of soil structure. Different from the traditional in s

Decoding geochemical signals of the Schwalbenberg Loess-Palaeosol-Sequences — A key to Upper Pleistocene ecosystem responses to climate changes in western Central Europe

Loess deposits are the most extent continental archives of climatic- and environmental change and represent important components of local and global dust systems. Consequently, their geochemistry provides an excellent basis for studying climate oscillations on land and how these affect processes in the terrestrial system. It is, however, challenging to assess information archived in loess records

Removal of Powerline Noise in Geophysical Datasets With a Scientific Machine-Learning Based Approach

The most common noise in geophysical data is probably interference from powerlines. This noise manifests itself as a sinusoidal signal oscillating at the fundamental 50 or 60 Hz frequency of the power grid and as harmonic components oscillating at integer multiples. Many different mitigation strategies, tailored for the specific geophysical method, have been developed to target powerline noise. On

Evolution and dysfunction of human cognitive and social traits : A transcriptional regulation perspective

Evolutionary changes in brain and craniofacial development have endowed humans with unique cognitive and social skills, but also predisposed us to debilitating disorders in which these traits are disrupted. What are the developmental genetic underpinnings that connect the adaptive evolution of our cognition and sociality with the persistence of mental disorders with severe negative fitness effects

Enabling In Situ Studies of Metal-Organic Chemical Vapor Deposition in a Transmission Electron Microscope

The world of environmental microscopy provides the possibility to study and analyze transformations and reactions during realistic conditions to understand the processes better. We report on the design and development of a metal-organic chemical vapor deposition (MOCVD) system integrated with an environmental transmission electron microscope intended for real-time investigations of crystal growth.

Coral-like WO3/BiVO4 photoanode constructed via morphology and facet engineering for antibiotic wastewater detoxification and hydrogen recovery

Morphology and facet engineering have been proved efficient strategies to prepare high-performance photoelectrochemical (PEC) materials. WO3/BiVO4 heterojunction photoanodes with different morphologies were prepared by simply controlling the amount of electrodeposited charge. The coral-like WO3/BiVO4 photoanode with the orientation growth of {110} and {011} active facets of BiVO4 exhibited the opt

Late Holocene peat paleodust deposition in south-western Sweden - exploring geochemical properties, local mineral sources and regional aeolian activity

Atmospheric mineral dust not only interacts with the climate system by scattering incoming solar radiation and affecting atmospheric photochemistry, but also contributes critical nutrients to marine and terrestrial ecosystems. In a high-resolution analysis of paleodust deposition, peat development and soil dust sources, we assess the interplay between dust deposition and bog development of the Dav

Högsta förvaltningsdomstolens (o)förmåga att våga fråga? - en analys av förhandsavgörandeinstitutets ställning på det direkta beskattningsområdet i Sverige

Skyldigheten att begära förhandsavgörande har under senare år aktualiserats i en rad avgöranden från EU-domstolen. Samtidigt som domstolen för första gången har fällt en medlemsstat för att inte uppfylla nämnda skyldighet i Kommissionen mot Frankrike (mål C-416/17) har EU-domstolen delvis lättat de krav som ställs på nationella domstolar genom den s.k. Cilfit-doktrinen. I en rykande färsk artikel,