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Head-to-head comparison of a Si-photomultiplier-based and a conventional photomultiplier-based PET-CT system

Background: A novel generation of PET scanners based on silicon (Si)-photomultiplier (PM) technology has recently been introduced. Concurrently, there has been development of new reconstruction methods aimed at increasing the detectability of small lesions without increasing image noise. The combination of new detector technologies and new reconstruction algorithms has been found to increase image

Clinical characteristics and histopathological patterns of hodgkin lymphoma and treatment outcomes at a tertiary cancer center in ethiopia

PURPOSE In developing countries, Hodgkin lymphoma (HL) affects the young population. In Ethiopia, nearly 70% of the population are, 35 years of age. Therefore, this study aimed to elucidate the age distribution, histopathologic patterns, clinical characteristics and treatment outcomes of HL in Ethiopia. MATERIALS AND METHODS Data from clinical records of 133 consecutive patients with HL between 20

Who Cares? : The Neoliberal Turn and Changes in the Articulations of Women’s Relation to the Swedish Welfare State

This article aims to investigate how articulations of women’s relation to the welfare state and modes of political agency has changed in Sweden between 1977 and 2017; a period characterized by the introduction and implementation of a neoliberal political rationality. By way of discourse analysis, the article highlights the reciprocal relationship between the construction of the welfare state and w

From Intrauterine to Extrauterine Life—The Role of Endogenous and Exogenous Factors in the Regulation of the Intestinal Microbiota Community and Gut Maturation in Early Life

Differentiation of the digestive tube and formation of the gut unit as a whole, are regulated by environmental factors through epigenetic modifications which enhance cellular plasticity. The critical period of DNA imprinting lasts from conception until approximately the 1,000th day of human life. During pregnancy, besides agents that may directly promote epigenetic programming (e.g., folate, zinc,

Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues

Galectin-1 is a β-galactoside-binding lectin with manifold biological functions. A single tryptophan residue (W68) in its carbohydrate binding site plays a major role in ligand binding and is highly conserved among galectins. To fine tune galectin-1 specificity, we introduced several non-canonical tryptophan analogues at this position of human galectin-1 and analyzed the resulting variants using g

Ultrasound and elastography in the assessment of skin involvement in systemic sclerosis : A systematic literature review focusing on validation and standardization – WSF Skin Ultrasound Group

Objective: To summarize the published evidence in the literature on the role of ultrasound and elastography to assess skin involvement in systemic sclerosis (SSc). Methods: A systematic literature review (SLR) was performed within the “Skin Ultrasound Working Group” of the World Scleroderma Foundation, according to the Cochrane Handbook. A search was conducted in Pubmed, Cochrane Library and Embas

Psychological self-protection in the face of climate change : A need-based empirical investigation of the spectrum of climate denial

Climate change is an existential threat to human survival, the social organization of society, and the stability of ecosystems. It is thereby profoundly frightening. In the face of threat, people often want to protect themselves instead of engaging in mitigating behaviors. When psychological resources are insufficient to cope, people often respond with different forms of denial. In this dissertati

Innovation measurement (1984-2014); a systematic review on the state of the art.

The interplay between innovation and measurement has fascinated scholars from several disciplines over the last decade. All these diverse contributions, however, have resulted in a current state of knowledge that is signified by large numbers of articles without clear integration and synthesis. Therefore the aim of this explorative study is to examine the theoretical notions of innovation and meas

Temperature imaging in low-pressure flames using diode lasers

We present a calibration free technique for spatially resolved imaging of flame temperature. Its application is demonstrated in a low pressure premixed methane flame seeded with indium. Temperature measurements over a range of equivalence ratios are investigated.

The Demographic Challenge Facing the EU: : Roads to Sustainability in an Ageing Europe

The pandemic put all underlying structural problems about the living conditions of older persons in Europe on display. The inadequate protection afforded to older persons during this crisis reflects the weak position of this group. Additionally, the growing ageing population in EU entails an urgent challenge to the union. In this chapter, I argue for what policies the EU needs to implement to ensu

Immune infiltrate in the primary tumor predicts effect of adjuvant radiotherapy in breast cancer : Results from the randomized SweBCG91RT trial

Purpose: Tumor-infiltrating immune cells play a key role in tumor progression. The purpose of this study was to analyze whether the immune infiltrate predicts benefit from postoperative radiotherapy in a large randomized breast cancer radiotherapy trial. Experimental Design: In the SweBCG91RT trial, patients with stage I and II breast cancer were randomized to breast-conserving surgery (BCS) and p

Hypoxic induction of exosome uptake through proteoglycan-dependent endocytosis fuels the lipid droplet phenotype in Glioma

As an adaptive response to hypoxic stress, aggressive tumors rewire their metabolic phenotype into increased malignant behavior through extracellular lipid scavenging and storage in lipid droplets (LD). However, the underlying mechanisms and potential lipid source retrieved in the hypoxic tumor microenvironment remain poorly understood. Here, we show that exosome-like extracellular vesicles (EV),