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Stromal cells and osteoclasts are responsible for exacerbated collagen-induced arthritis in interferon-beta-deficient mice.
Stem cell therapy for Parkinson's disease: where do we stand?
A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor ti
Severe malformation in neonate Vipera ursinii rakosiensis
Predicting 5-year outcome in first-episode psychosis: Construction of a prognostic rating scale
Objective: The aim of this study was to construct a rating scale to predict long-term outcome on the basis of clinical and sociodemographic characteristics in patients with symptoms of psychosis who seek psychiatric help for the first time. Method: Patients (N = 153) experiencing their first episode of psychosis (DSM-IV schizophrenia, schizophreniform disorder, schizoaffective disorder, brief psyc
Social capital and leisure time physical activity: a population based multilevel analysis in Malmo, Sweden
Objective: To investigate the influence of social capital and individual factors on the level of leisure time physical inactivity in the neighbourhoods. Methods: The public health survey in Malm 1994 is a cross sectional study. A total of 5600 people aged 2080 years were invited to answer a postal questionnaire. The participation rate was 71. A multilevel logistic regression model, with individual
Caffeine poisoning and lactate rise: an overlooked toxic effect?
Severe caffeine poisoning is rare but associated with a high mortality. The symptoms are mainly attributable to hyperadrenergic stimulation, are relatively well known and described in the literature. Transient rises in plasma lactate levels may occur but are, however, less well described. We present a case of serious caffeine poisoning with a concomitant rise in lactate treated with a non-selectiv
Minimal periodic orbit structure of 2-dimensional homeomorphisms
We present a method for estimating the minimal periodic orbit structure, the topological entropy, and a fat representative of the homeomorphism associated with the existence of a finite collection of periodic orbits of an orientation-preserving homeomorphism of the disk D-2. The method focuses on the concept of fold and recurrent bogus transition and is more direct than existing techniques. In par
Li insertion in sol-gel prepared Mn-doped TiO2 studied by electron spectroscopy in ultrahigh vacuum
The properties of a sol-gel prepared Mn-modified TiO2 film have been studied with X-ray absorption spectroscopy (XAS) and photoelectron spectroscopy (PES) using synchrotron radiation. The chemical composition and oxidation state of the elements have been determined. The manganese content estimated by PES of the Mn-modified film is about 10% and both Mn2+ and Mn3+ are observed. Addition of Mn is fo
Sex differences in the relationships between BMI, WHR and incidence of cardiovascular disease: a population-based cohort study.
Objective: Body mass index (BMI) is associated with increased incidence of cardiovascular disease (CVD). However, the risk could be very different for individuals with the same body mass. The present study explored whether regional fat distribution, as measured by waist-hip ratio (WHR), could modify the impact of BMI on the risk of CVD in men and women. Design: Prospective population-based study.
Clinical rating of dyskinesias in Parkinson's disease: use and reliability of a new rating scale
Drug-induced dyskinesias (DID) manifested as hyperkinetic and/or dystonic movements or postures are common problems in Parkinson's disease (PD). Novel therapeutic interventions may offer possibilities to counteract these common adverse effects of an otherwise necessary treatment. To be able to evaluate the effects of such interventions on DID, reliable and relevant clinical assessment tools are ne
Plastid DNA haplotype variation in Dactylorhiza incarnata (Orchidaceae): evidence for multiple independent colonization events into Scandinavia
The early marsh orchid, Dactylorhiza incarnata (L.) Soo s. l., grows in medium-rich to rich fens and marshes over much of Europe and parts of Asia. The species is highly polymorphic and different forms may grow together at the same site. In the present study, I tested the hypothesis that these forms represent different migrant populations that have colonized Scandinavia independently of each other
The importance of porphyrin distortions for the ferrochelatase reaction.
Ferrochelatase is the terminal enzyme in haem biosynthesis, i.e. the enzyme that inserts a ferrous ion into the porphyrin ring. Suggested reaction mechanisms for this enzyme involve a distortion of the porphyrin ring when it is bound to the enzyme. We have examined the energetics of such distortions using various theoretical calculations. With the density functional B3LYP method we calculate how m
Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years
Background A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. Methods The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data
The effect of shaking regime on the rate and extent of enzymatic hydrolysis of cellulose
In an attempt to elucidate the effect of mixing on the rate and extent of enzymatic hydrolysis of cellulosic substrates, alpha -cellulose was hydrolysed using a commercial cellulase preparation at varying levels of substrate concentration (2.5,5 and 7.5% (w/v)) and by using three shaking regimes: continuous at low-speed (25 rpm), continuous at high-speed (150 rpm) and an intermittent regime compri
Reconstruction of attosecond pulse trains using an adiabatic phase expansion
We propose a new method to reconstruct the electric field of attosecond pulse trains. The phase of the high-order harmonic emission electric field is Taylor expanded around the maximum of the laser pulse envelope in the time domain and around the central harmonic in the frequency domain. Experimental measurements allow us to determine the coefficients of this expansion and to characterize the radi
Nonablative neonatal bone marrow transplantation rapidly reverses severe murine osteopetrosis despite only minimal engraftment and no evidence of selective recruitment of cells to the osteoclastic lineage
The development of generic maDur/man for the construction of discourse stance in Icelandic and Swedish
The paper compares two lexical items, Icelandic ma@?ur and Swedish man, for the construction of a detached, general discourse stance (Berman, Ragnarsdottir and Stromqvist, 2002). Both forms mean 'man', but they can also be used in a generic sense. In that usage, Icelandic ma@?ur is associated with several semantic, pragmatic, and stylistic constraints, whereas Swedish man is more freely applicable
The declining spadefoot toad Pelobates fuscus: calling site choice and conservation
We investigated whether local biotic and abiotic conditions could explain the occurrence of calling males of the declining spadefoot toad Pelobates fuscus in 72 ponds in southern Sweden. The ponds covered the entire distribution range of P. fuscus and were monitored during the breeding season in 2000. Calling males were found in 33 ponds. representing ca 50% of all known ponds for the species ill
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women b