Previous studies have shown that ventilation patterns affect absorption of inhaled compounds. Thus, the aim of this study was to investigate the effect of large tidal volume ventilation (LTVV) on the absorption of inhaled insulin in rabbits. Mechanically ventilated rabbits were given human insulin via a nebuliser system, and plasma insulin was measured for the following 120 min. Ventilation was ad

The European Study on Adult Well-being (ESAW), funded by the European Union, was conducted during 2002 and 2003 in Austria, Italy, Luxembourg, The Netherlands, United Kingdom and Sweden. The aim of the interdisciplinary study was the conceptual clarification and the identification of factors contributing to life satisfaction for older people. Five key components were included in the study: (1) phy

Secretoneurin is a neuropeptide potentially involved in migration of eosinophils, monocytes, and dendritic cells. Whether secretoneurin is present in the human airway mucosa and whether it is released at ongoing allergic airway inflammation is currently unknown. In patients with allergic rhinitis, we have explored the occurrence of secretoneurin in nasal mucosal biopsies and lavage fluids before a

Background-The time course and magnitude of infarct involution, functional recovery, and normalization of infarct-related electrocardiographic (ECG) changes after acute myocardial infarction (MI) are not completely known in humans. We sought to explore these processes early after MI and during infarct-healing using cardiac MRI. Methods and Results-Twenty-two patients with reperfused first-time MI

Animals foraging in a heterogeneous environment may combine prior information on patch qualities and patch sample information to maximize intake rate. Prior information dictates the long-term expectations, whereas prior information in combination with patch sample information determines when to leave an individual food patch. We examined patch use behaviour of benthic feeding fish in their natural

Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjogren's syndrome ( pSS) and relate these to autonomic nervous function. Methods: Twenty consecutive pSS patients, according to the American - European Consensus Criteria ( AECC), and 30 age- and sex- matched controls from the Swedish general population registry were studied. All s

In vivo studies on rats have demonstrated that considerable amounts of iodide are transported from the bloodstream into the gastric lumen. The mechanisms for and functional significance of this transport are poorly understood. Active (driven by Na+/K+-ATPase) iodide transport into thyroid follicular cells is mediated by the sodium-iodide symporter (NIS), which is also abundantly expressed in gastr

Genetic engineering has been used for fusion of peptides, with different length and composition, on a protein to study the effect on partitioning in an aqueous two-phase system. The system was composed of dextran and the thermoseparating ethylene oxide-propylene oxide random copolymer, EO30PO70. Peptides containing tryptophan, proline, arginine or aspartate residues were fused at the C-terminus of

Rhes is a small GTP-binding protein prominently localized in the striatum. Previous findings obtained in cell culture systems demonstrated an involvement of Rhes in cAMP/PKA signalling pathway, at a level proximal to the activation of heterotrimeric G-protein complex. However, its role in the striatum has been, so far, only supposed. Here we studied the involvement of Rhes in dopaminergic signalli

A comparative study of light pf shell nuclei using cranked Nilsson-Strutinsky model and the spherical shell model indicates that some of the signature splitting between the partner bands in odd-A nuclei originates from a gradual decrease in the contents of the pairing energy as spin increases.

The 'buck-passing' account equates the value of an object with the existence of reasons to favour it. As we argued in an earlier paper, this analysis faces the 'wrong kind of reasons' problem: there may be reasons for pro-attitudes towards worthless objects, in particular if it is the pro-attitudes, rather than their objects, that are valuable. Jonas Olson has recently suggested how to resolve thi

Two native grasses, Festuca ovina of dry and Agrostis stolonifera mainly of moist habitats of calcareous grasslands, were studied in an experiment with the objective of elucidating the effect of soil moisture level on soil solution chemistry, biomass production and shoot mineral nutrients. Eight levels of moisture, corresponding to 30-100% of the water-holding capacity (WHC) of the soil, were test

OBJECTIVE: Congestive heart failure (CHF) is accompanied by impaired peripheral blood flow and endothelial dysfunction with decreased release of nitric oxide (NO). Strong evidence supports the existence of another vasodilatory substance, endothelium derived hyperpolarising factor (EDHF), which has not previously been studied in CHF. METHOD: CHF was induced by left coronary artery ligation resultin

Amphiphilic graft copolymers consisting of methacrylate backbones carrying approximately 48 wt.% of ethylene oxide [(EO)(9) or (EO)(23)] side chains as ionophilic groups and fluorocarbon or hydrocarbon side chains as ionophobic groups were prepared. Solid polymer electrolytes based on the copolymers and lithium bis(trifluoromethylsulfonyl)imide (LiTFSI) were characterized by DSC and the impedance

Maternal hormones can have substantial phenotypic effects in the progeny of many vertebrates. It has been proposed that mothers adaptively adjust hormone levels experienced by particular young to optimize their reproductive output. In birds, systematic variation in egg hormone levels has been related to different female reproductive strategies. Because in many bird species prospects of the offspri

To describe lifetime mental disorders among perpetrators of severe inter-personal crimes and to identify the problem domains most closely associated with aggression and a history of repeated violent criminality, we used structured interviews, clinical assessments, analyses of intellectual functioning, medical and social files, and collateral interviews in 100 consecutive subjects of pretrial foren

Background. The use of left ventricular assist devices (LVADs) is established as a bridge to heart transplantation. Methods. All Swedish patients on the waiting list for heart transplantation, treated with LVAD since 1993 were retrospectively collected into a database and analyzed in regards to risk factors for mortality and morbidity. Results. Fifty-nine patients (46 men) with a median age of 49

Somatostatin (SST) is a peptide hormone active in the regulation of the endocrine system via different somatostatin receptors subtypes. It inhibits the release of multiple secondary peptide hormones, affecting neurotransmission and cell proliferation. SST has a high therapeutic potential in the treatment of disease, such as acromegali, acute pancreatitis and gastroenteropathic endocrine tumors. Ho