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Fisher information for smart sampling in time-domain spectroscopy

Time-domain spectroscopy encompasses a wide range of techniques, such as Fourier-transform infrared, pump-probe, Fourier-transform Raman, and two-dimensional electronic spectroscopies. These methods enable various applications, such as molecule characterization, excited state dynamics studies, or spectral classification. Typically, these techniques rarely use sampling schemes that exploit the prio

Combining CD40 agonist mitazalimab with mFOLFIRINOX in previously untreated metastatic pancreatic ductal adenocarcinoma (OPTIMIZE-1) : a single-arm, multicentre phase 1b/2 study

Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour activity of mitazalimab, a human CD40 agonistic IgG1 antibody, with modified FOLFIRINOX (mFOLFIRINOX; fluorouracil, leucovorin, oxaliplatin, and irinotecan), in chemotherapy-naive patients

Design strategies to reduce personal protective equipment noncompliance

Personal Protective Equipment (PPE) noncompliance has been addressed through various lenses. In current literature, there is a greater focus on improving training and safety culture. Improving PPE design to persuade PPE compliance is less explored, especially in sectors beyond healthcare. This study investigates the reasons behind PPE noncompliance across construction, maritime, and chimney sweepiPersonal Protective Equipment (PPE) noncompliance has been addressed through var-ious lenses. In current literature, there is a greater focus on improving training andsafety culture. Improving PPE design to persuade PPE compliance is less explored,especially in sectors beyond healthcare. This study investigates the reasons behindPPE noncompliance across construction, maritime, and chimney sweeping

Seasonal patterns and processes of migration in a long-distance migratory bird : Energy or time minimization?

Optimal migration theory prescribes adaptive strategies of energy, time or mortality minimization. To test alternative hypotheses of energy- and time-minimization migration we used multisensory data loggers that record time-resolved flight activity and light for positioning by geolocation in a long-distance migratory shorebird, the little ringed plover, Charadrius dubius. We could reject the hypot

Acral Melanoma Incidence and Survival Trends in 1990–2020: A Nationwide, Population-based Study

Acral melanoma is a clinical subtype of melanoma with high mortality, on which research is limited in scope. This study aimed to assess incidence trends and melanoma-specific survival rates for acral melanoma in the Swedish population from 1990 to 2020.This cross-sectional study included patients with an acral melanoma diagnosis from 1990 to 2020 from the nationwide, population-based Swedish Melan

AeoLiS : Numerical modelling of coastal dunes and aeolian landform development for real-world applications

The formation and evolution of coastal dunes result from a complex interplay of eco-morphodynamic processes. State-of-the-art models can simulate aeolian transports and morphological dune evolution under certain conditions. However, a model combining these processes for coastal engineering applications was not yet available. This study aims to develop a predictive tool for dune development to info

Assessment of precision and accuracy of brain white matter microstructure using combined diffusion MRI and relaxometry

Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter (WM), we designed an optimal diffusion-relaxometry MRI protocol that samples multiple b-values, B-tensor shapes, and echo times (TE). This variable-TE protocol (27 min) has as subsets a fixed-TE protocol (15 min) and a tw

Inflammatory imbalance in tracheal aspirate of very preterm newborns is associated with airway obstruction and lung function deficiencies at school age : a cohort study

Objective A low expression of club cell secretory protein (CC16) and high levels of proinflammatory cytokines at preterm birth are associated with airway inflammation and more severe neonatal lung disease. The present study aimed to investigate if low levels of CC16, proinflammatory cytokines and vascular endothelial growth factors (VEGF) in tracheal aspirate early after birth were associated with

Are demographics, physical function and psychological response associated with return to sport at one year following ACL-reconstruction?

Objective: To determine the relative contribution of each of the following aspects: demographics, physical function, and patient-reported outcome measures (PROMs), including both physical and psychological constructs, to return to sport (RTS) (any level) one-year post anterior cruciate ligament reconstruction (ACLR). Design: Cross-sectional cohort study. Methods: We included data for 143 participa

Geometry-Biased Transformer for Robust Multi-View 3D Human Pose Reconstruction

We address the challenges in estimating 3D human poses from multiple views under occlusion and with limited overlapping views. We approach multi-view, single-person 3D human pose reconstruction as a regression problem and propose a novel encoder-decoder Transformer architecture to estimate 3D poses from multi-view 2D pose sequences. The encoder refines 2D skeleton joints detected across different

Consistent time allocation fraction to vegetation green-up versus senescence across northern ecosystems despite recent climate change

Extended growing season lengths under climatic warming suggest increased time for plant growth. However, research has focused on climatic impacts to the timing or duration of distinct phenological events. Comparatively little is known about impacts to the relative time allocation to distinct phenological events, for example, the proportion of time dedicated to leaf growth versus senescence. We use

The Role of Deposition of Cosmogenic 10Be for the Detectability of Solar Proton Events

The manifestation of extreme solar proton events (SPEs) in Beryllium-10 (10Be) ice core data contains valuable information about the strength and incidence of SPEs or local characteristics of the atmosphere. To extract this information, the signals of enhanced production of cosmogenic 10Be due to the SPEs have to be detected, hence distinguished from the variability of the background production by

Highly versatile, two-color setup for high-order harmonic generation using spatial light modulators

We present a novel, interferometric, two-color, high-order harmonic generation setup based on a turn-key Ytterbium-doped femtosecond laser source and its second harmonic. Each interferometer arm contains a spatial light modulator with individual capabilities to manipulate the spatial beam profiles and to stabilize the relative delay between the fundamental and the second harmonic. In addition, sep

Sex Differences in Children with Uncomplicated Attention Deficit/Hyperactivity Disorder and Sleep Problems

Background: Approximately 7.6% of children are diagnosed with attention deficit/hyperactivity disorder (ADHD), and sleep impairments affect 25–85%. There is a noticeable lack of research on girls and sex differences. The aim of this study was to examine sex differences in children with uncomplicated ADHD and sleep problems. Methods: Cross-sectional baseline data were retrieved from a randomized co

What does racial ascription have to do with perception of Swedishness?

How do Swedes, who are not exposed to administrative routines of reporting race and ethnicity, perceive, and categorize faces with different phenotypical features? This study examines identity contestation that can occur and address how race affects the way you are perceived as Swedish. A sample of Swedish participants were asked to assign racial categories to images of faces with different phenot

Multiphase Flow Dynamics: Insights from Single Microchannels to Porous Media with Uniform and Hierarchical Microchannel Networks

Multiphase flow in porous media are widespread in emerging subsurface application including geological carbon sequestration and underground hydrogen storage. Multiple fluid interactions introduce more complexity compared to single phase flow. On the gas-liquid interface, mass transfer and interfacial instability may arise. The study of multi-phase interaction behaviour allows the insights gained t

Spatiotemporal sphingosine-1-phosphate receptor 3 expression within the cerebral vasculature after ischemic stroke

Sphingosine-1-phosphate receptors (S1PRs) are promising therapeutic targets in cardiovascular disease, including ischemic stroke. However, important spatiotemporal information for alterations of S1PR expression is lacking. Here, we investigated the role of S1PR3 in ischemic stroke in rodent models and patient samples. We show that S1PR3 is acutely upregulated in perilesional reactive astrocytes af

Synchrotron X-ray spectromicroscopy analysis of wear tested graphene-containing alumina coatings

Thermally sprayed Al2O3 coatings containing graphene nano platelets (GNP) have been shown to exhibit improved wear resistance. To understand the positive influence of GNP on wear properties, scanning transmission X-ray microscopy (STXM) analyses were performed to determine the structural and chemical changes that occur on the GNP and alumina matrix after wear tests. STXM results acquired at the C

Migrants as sustainability actors : Contrasting nation, city and migrant discourses and actions

Although it is widely recognized that migration is socially transformative, the potential contributions of migrants to transformations towards sustainability in their destination areas are often overlooked in mainstream discourse on environmentalism and sustainability. Here we seek to identify current narratives of migrants and sustainability across individual, urban, and national scales. Migrants