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On the role of excited species in hydrogen combustion

Recently updated hydrogen combustion mechanism was combined with ozone decomposition reactions and extended by reactions of excited species: O(D-1), OH((2)Sigma(+)), and O-2(a(1)Delta g). The reliability and the accuracy of the rate constants pertinent to these excited species were evaluated. Many reactions proposed in the literature and implemented in other kinetic schemes were found irrelevant o

Constrained capacities for faster-than-Nyquist signaling

This paper deals with capacity computations of faster-than-Nyquist (FTN) signaling. It shows that the capacity of FTN is higher than the orthogonal pulse linear modulation capacity for all pulse shapes except the sinc. FTN signals can in fact achieve the ultimate capacity for the signal power spectral density (PSD). The paper lower and upper bounds the FTN capacity under the constraint of finite

The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

Popular Abstract in Swedish Diabetes är en grupp sjukdomar som alla kännetecknas av en förhöjd nivå av sockerarten glukos i blodet. Antalet individer som drabbas av diabetes ökar hela tiden, en utveckling som ses över hela världen. Bara i Sverige har drygt 5% av befolkningen diagnosen diabetes, motsvarande 484.400 personer i åldern 20-79 år. Typ 2 diabetes är den vanligaste formen av diabetes, ochThe incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. The aim of this thesis was to explore the role of DNA methylation and common genetic variation on glucose metabolism a

Lentivirus-Induced Dendritic Cells for Immunization Against High-Risk WT1(+) Acute Myeloid Leukemia

Wilms' tumor 1 antigen (WT1) is overexpressed in acute myeloid leukemia (AML), a high-risk neoplasm warranting development of novel immunotherapeutic approaches. Unfortunately, clinical immunotherapeutic use of WT1 peptides against AML has been inconclusive. With the rationale of stimulating multiantigenic responses against WT1, we genetically programmed long-lasting dendritic cells capable of pro

Scattering matrix method for optical excitation of surface plasmons in metal films with periodic arrays of subwavelength holes

We present the formulation of a scattering matrix method for the study of light-scattering properties of metal films. The method is employed for the study of the optical excitation of surface plasmons in a gold film of 15-230 nm thickness, patterned periodically with subwavelength nanoholes. The gold film is placed on a thick SiO2 wafer, and the nanoholes as well as the top side of the gold film a

Modeling Symmetric Macromolecular Structures in Rosetta3

Symmetric protein assemblies play important roles in many biochemical processes. However, the large size of such systems is challenging for traditional structure modeling methods. This paper describes the implementation of a general framework for modeling arbitrary symmetric systems in Rosetta3. We describe the various types of symmetries relevant to the study of protein structure that may be mode

WNT5A Signaling Contributes to A beta-Induced Neuroinflammation and Neurotoxicity

Neurodegenration is a pathological hallmark of Alzheimer's disease (AD), but the underlying molecular mechanism remains elusive. Here, we present evidence that reveals a crucial role of Wnt5a signaling in this process. We showed that Wnt5a and its receptor Frizzled-5 (Fz5) were up-regulated in the AD mouse brain, and that beta-amyloid peptide (A beta), a major constituent of amyloid plaques, stimu

Three-pulse photon echo peak shift in optically dense samples

We have investigated the dependence of the three-pulse photon echo peak-shift (3PEPS) signal on solute concentration and sample path length. The most prominent effect is an increase of the amplitude of the long decay component of the 3PEPS at high optical densities, but signal distortions are observed for all timescales in the experiments. The distortions of the peak shift signal are more severe f

Allogeneic hematopoietic stem cell transplant with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: does donor T-cell engraftment 3 months after transplant predict survival?

Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall sur

Factors Regulating Neurogenesis in Intact and Pathological Brain: Role of TNF-alpha

During the last decade it has been clearly demonstrated that the adult brain contains neural stem cells (NSCs) localized mainly in two regions: the subgranular zone in the dentate gyrus and the subventricular zone (SVZ) lining the lateral ventricles. In the intact brain, these NSCs give rise to new dentate granule cells and olfactory bulb neurons, respectively. Following a brain damage such as str

Uncertainty in QSAR predictions.

It is relevant to consider uncertainty in individual predictions when quantitative structure-activity (or property) relationships (QSARs) are used to support decisions of high societal concern. Successful communication of uncertainty in the integration of QSARs in chemical safety assessment under the EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) system can be faci

Negotiations on information-seeking expertise: A study of web-based tutorials for information literacy

Abstract: Purpose – The purpose of this paper is to show how different approaches to information literacy, such as are mediated through web-based tutorials, are used as tools in negotiating the information-seeking expertise of university librarians. Design/methodology/approach – A textual analysis of 31 web-based Scandinavian tutorials for information literacy has been conducted. The similarities

Bootstrap Percolation on a Graph with Random and Local Connections

Let be a superposition of the random graph and a one-dimensional lattice: the n vertices are set to be on a ring with fixed edges between the consecutive vertices, and with random independent edges given with probability p between any pair of vertices. Bootstrap percolation on a random graph is a process of spread of "activation" on a given realization of the graph with a given number of initially