We present a Monte Carlo algorithm for Hamiltonicity detection in an $n$-vertex undirected graph running in $O(1.657^{n})$ time. To the best of our knowledge, this is the first superpolynomial improvement on the worst case runtime for the problem since the $O^*(2^n)$ bound established for the traveling salesman problem (TSP) over 50 years ago [R. Bellman, J. Assoc. Comput. Mach., 9 (1962), pp. 61-

Background: To ensure a correct interpretation of results obtained with quantitative real-time reverse transcription-polymerase chain reaction (RT-qPCR), it is critical to normalize to a reference gene with stable mRNA expression in the tissue of interest. GADPH is widely used as a reference gene in ovarian tumour studies, although lacking tissue-specific stability. The aim of this study was to id

The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodimeric complex of RelA and p50 subunits that interact with the DNA, regulating the expression of several genes; its dysregulation can trigger diverse diseases including inflammation, immunodeficiency, and cancer. There is some experimental evidence, based on whole cells studies, that natural sesquiterpene lac

A novel method for characterization of f-wave morphology in atrial fibrillation (AF) is presented. The method decomposes atrial activity into fundamental and harmonic components, dividing each component into short blocks for which the amplitudes, frequencies, and phases are estimated. The phase delays between the fundamental and each of the harmonics, here referred to as harmonic phase relationshi

Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis. The serine protease Factor I (FI) is the central inhibitor of complement degrading complement components C3b and C4b in the presence of cofactors such as C4b-binding protein (C4BP) and Factor H (FH). Yet, the

Over the last years an expanding family of small non-coding RNAs (sRNA) has been identified in eukaryotic genomes which behave as sequence-specific triggers for mRNA degradation, translation repression, heterochromatin formation and genome stability. To achieve their effectors functions, sRNAs associate with members of the Argonaute protein family. Argonaute proteins are segregated into three para

Popular Abstract in Swedish Diabetes är en folksjukdom som kännetecknas av förhöjda halter av glukos i blodet (hyperglykemi). Sockerarter i maten vi äter omvandlas till glukos, som i sin tur tar sig in i blodcirkulationen och distribueras till olika celler i kroppen. När blodsockernivån höjs utsöndras ett hormon, insulin, från β-cellerna i de Langerhanska öarna i bukspottkörteln. Insulin stimuleraType 2 diabetes is rapidly increasing worldwide thereby posing a severe burden on individual and public health. Although this increase can be ascribed to both genetic and environmental factors, until 2007, the genetic factors have been largely restricted to a few candidate genes based upon our limited knowledge of the pathogenesis of the disease. In an attempt to identify underlying genetic loci,

This article deals with the earliest version of post-mortem photography concentrating on the effects of such pictures on the present-day viewer. The encounter with these artefacts begins from a phenomenological point of view as I try to describe my personal experience of coming face to face with the image. I claim that the relation between the perceiver and the photograph does not just simply chan

Older people often have companion animals, and the significance of animals in human lives should be considered by nurses-particularly in relation to older people's health, which can be affected by diseases. The incidence of stroke increases with age and disabilities as a result of stroke are common. This study aimed to explore older people's experiences of living with companion animals after strok

The catalytic cycle of multicopper oxidases (MCOs) involves intramolecular electron transfer (IET) from the Cu-T1 copper ion, which is the primary site of the one-electron oxidations of the substrate, to the trinuclear copper cluster (TNC), which is the site of the four-electron reduction of dioxygen to water. In this study we report a detailed characterization of the kinetic and electrochemical p

Electromagnetic interactions between colliding heavy ions at the Large Hadron Collider (LHC) at CERN will give rise to localized beam losses that may quench superconducting magnets, apart from contributing significantly to the luminosity decay. To quantify their impact on the operation of the collider, we have used a three-step simulation approach, which consists of optical tracking, a Monte Carlo

The aim of this study was to characterize myelin loss as one of the features of white matter abnormalities across three common dementing disorders. We evaluated post-mortem brain tissue from frontal and temporal lobes from 20 vascular dementia (VaD), 19 Alzheimer's disease (AD) and 31 dementia with Lewy bodies (DLB) cases and 12 comparable age controls. Images of sections stained with conventional

Background: rs10993994, a single nucleotide polymorphism (SNP) at the genetic locus encoding beta-microseminoprotein (beta-MSP), is associated with both prostate cancer risk and levels of blood prostate-specific antigen (PSA), a biomarker used in prostate cancer screening. Therefore, we wished to determine the association between SNPs at MSMB, the gene encoding beta-MSP, and the levels of prostate

Monte Carlo simulation is frequently employed to compute p-values for test statistics with unknown null distributions. However, the computations can be exceedingly time-consuming, and, in such cases, the use of pre-computed simulations can be considered to increase speed. This approach is attractive in principle, but complicated in practice because the size of the pre-computed data can be prohibit

Magnetic materials with high magnetic coercivity (Hc), magnetic anisotropy (Ku) and low Gilbert damping (α) are of great importance for future spintronics devices. For instance, for spin-transfer-torque (STT) memory devices low α and high Ku are desired. Such a combination of material properties includes a built in contradiction since both Ku and α are dependent on the spin-orbit interaction (SO);