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Social Entrepreneurship: Cases and Concepts

When is the right time to start up a social venture? How should it price its first services? What constituencies should be considered when shaping the board? What collaborations should the venture establish? When is it time to expand? And to close down? How can long-term economic sustainability be achieved? Which scaling-up strategy is most appropriate? How can social impact be assessed? These are

Mixed support for a causal link between single dose intranasal oxytocin and spiritual experiences : opposing effects depending on individual proclivities for absorption

Intranasal oxytocin (OT) has previously been found to increase spirituality, an effect moderated by OT-related genotypes. This pre-registered study sought to conceptually replicate and extend those findings. Using a single dose of intranasal OT vs placebo (PL), we investigated experimental treatment effects, and moderation by OT-related genotypes on spirituality, mystical experiences, and the sens

Culture and Identity in Organization Studies

This chapter deals with culture and identity in management studies. An interest in culture and identity can be understood as an interest in the symbolic side of the organization that deals with meaning, interpretation, symbols and action (rather than behavior). The symbolic side of enterprise has always been present in organization studies; since the early 1980s, however, this has predominantly be

Overcoming inertia: The social question in social entrepreneurship

The literature on social entrepreneurship continues to grow. This research is novel and vibrant, yet erratic and fragmented. In this chapter I first organize the burgeoning social-entrepreneurship literature into two streams: one conceptual stream concerned with defining social entrepreneurship; a second management- oriented stream concerned with the establishment and development of social venture

Powerful Dichotomies: Inclusion and exclusion in the Information Society

Technological development, in particular the development of information and communicatiion technologies (ICT), is often presented as the answer to many social problems. Proponents of the Information Society suggest that poverty, failing integration, unemployment, and llack of democracy can be addressed with the appropriate technological means. Inequality iis often framed in terms of a digital divi

Management of concussion in soccer

BACKGROUND: When participating in contact sports, (mild) head trauma is a common incident-observed in both professional and amateur sports. When head trauma results in transient neurological impairment, a sports-related concussion has occurred. Acute concussion, repetitive concussions, as well as cumulative "sub-concussive" head impacts may increase the risk of developing cognitive and behavioral

Management of symptomatic sacral perineural cysts with microsurgery and a vascularized fasciocutaneous flap

Background: The optimal treatment of symptomatic perineural (Tarlov) cysts is controversial. Numerous surgical techniques have been proposed with conflicting results. A series of Tarlov cysts treated with a novel surgical approach is presented.Methods: Patients with surgically treated symptomatic perineural cysts during 2013-2016 were included. The main indications for surgery were persistent radi

Intracranial pressure elevations in diffuse axonal injury : association with nonhemorrhagic MR lesions in central mesencephalic structures

OBJECTIVEIncreased intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI) with diffuse axonal injury (DAI) is not well defined. This study investigated the occurrence of increased ICP and whether clinical factors and lesion localization on MRI were associated with increased ICP in patients with DAI.METHODSFifty-two patients with severe TBI (median age 24 years, range 9-61

Levelling Vagueness: A study of cultural diversity in an international project group

Imagine one Brit, one Dutch, two North Americans, one Spaniard and three Swedes setting up a joint international research project. Their areas of expertise vary: sociology, labour law and organisational theory. The scene is taking place in a hotel conference room in Uppsala. The North Americans are tired from the long trip and the jet-lag. The Spaniard arrived later than everybody, including himse

Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury

Phenotypic changes of myeloid cells are critical to the regulation of premature aging, development of cancer, and responses to infection. Heme metabolism has a fundamental role in the regulation of myeloid cell function and activity. Here, we show that deletion of heme oxygenase-1 (HO-1), an enzyme that removes heme, results in an impaired DNA damage response (DDR), reduced cell proliferation, and

Shared heritability and functional enrichment across six solid cancers

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate

Effect of a lifestyle-focused electronic patient support application for improving risk factor management, self-rated health, and prognosis in post-myocardial infarction patients : study protocol for a multi-center randomized controlled trial

BACKGROUND: Cardiac rehabilitation (CR) programs addressing risk factor management, educational interventions, and exercise contribute to reduce mortality after myocardial infarction (MI). However, the fulfillment of guideline-recommended CR targets is currently unsatisfactory. eHealth, i.e., the use of electronic communication for healthcare, including the use of mobile smartphone applications co