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Molecular design of recombinant scFv antibodies for site-specific photocoupling to β-cyclodextrin in solution and onto solid support.

The ability to design and tailor-make antibodies to meet the biophysical demands required by the vast range of current and future antibody-based applications within biotechnology and biomedicine will be essential. In this proof-of-concept study, we have for the first time tailored human recombinant scFv antibodies for site-specific photocoupling through the use of an unnatural amino acid (UAA) and

Methods for autofluorescence analysis of uterine cavity washings

The diagnostics of endometrial pathology can be done by obtaining information at the molecular level, e. g. using the autofluorescence-based technique. Thus, for the first time an experimental study was performed on waste material of uterine cavity washing specimens to evaluate suitability of the technique for diagnostics. The specimens were obtained from 32 patients who had a conventional uterine

Determinants that Influence ERP Use and Value: Cross-Country Evidence on Scandinavian and Iberian SMEs

Enterprise resource planning (ERP) use and ERP value are of high interest among both academia's as well as practitioners. Despite different views of gained value from implemented ERP, there are some studies focusing in larger companies, however, few studies report on challenges experienced by Small and Medium sized Enterprises (SMEs). Based on diffusion of innovation (DOI) literature and resource-

The effect of polycations on early cement paste

This paper studies the possibility for improving the ductility of cement based materials by means of oligocationic additives. Actually, the setting of cement is due to ionic correlation forces between highly negatively charged C-S-H nanoparticles throughout a calcium rich solution. The main drawback of this strong attraction is its very short range that results in low elastic deformation of hydrat

Resource Management on Multicore Systems: The ACTORS Approach

High-performance embedded systems require the execution of many applications on multicore platforms and are subject to stringent restrictions and constraints. The actors project approach provides temporal isolation through resource reservation over a multicore platform, adapting the available resources on the basis of the overall quality requirements. The architecture is fully operational on both

Historia på frukostbordet. Historiebruk i två nordiska dagstidningar 1987 och 2012

How frequently and in what ways does history figure in daily news media? This study revisits an investigation of history in two leading Scandinavian newspapers, the Danish Politiken and the Swedish Dagens Nyheter, which was undertaken in 1987. Twenty-five years later, the results of this study are compared to an investigation of historical content in the same two newspapers in 2012. The frequency

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the

Prognostic impact of array-based genomic profiles in esophageal squamous cell cancer

Background: Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based comparative genomic hybridization (aCGH) to obtain a whole genome copy number profile

Investigations of vesicle gels by pulsed and modulated gradient NMR diffusion techniques

Vesicle gels are surfactant systems that form stiff gels with rather low amounts of surfactant. So far their structures have mostly been investigated using scattering techniques, which are generally appropriate for the study of structures on the nm-length-scale. Here we examine these gels using two complementary diffusion NMR techniques, which are both sensitive to structures on the mu m-scale. Th

Design of a horizontal neutron reflectometer for the European Spallation Source

A design study of a horizontal neutron reflectometer adapted to the general baseline of the long pulse European Spallation Source (ESS) is presented. The instrument layout comprises advanced solutions for the neutron guide, high-resolution pulse shaping and beam bending onto a sample surface being thoroughly adjusted to the properties of the ESS. The length of this instrument is roughly 55 m, enab

Aliphatic pincer-type POCOP ligands and their complexation behaviour with iridium: Crystal structure of an iridium(III) phosphinite complex

Reaction of 2 equivalents of 1,3-bis-(di-tert-butylphosphinito)-2-methyl-propane (1a) with [Ir(COD)Cl](2) affords the first aliphatic diphosphinite PCP pincer complex with iridium, Ir(H){(t-Bu2POCH2)(2)C(Me)}Cl (2). The poor yield of 2 is partly explained by the formation of a di-nuclear byproduct [IrCl(COD)](2)(mu(2)-{(t-Bu2POCH2)(2)CH(Me)}) (3). Reaction of 1,3-bis-(di-iso-propylphosphinito)-2-m

Applications of SU-8 in the development of a Single Ion Hit Facility

The Lund Nuclear Microprobe (LNM) has been adapted to be used as a Single Ion Hit Facility (SIHF) for proton cell irradiation experiments at low dose. In order to test the capabilities of the system, Ni dot arrays and artificial cells have been fabricated with the photopolymer SU-8 and common lithographic techniques. The primary purpose of the Ni dot arrays was to determine the targeting accuracy

MicroRNA-7a regulates pancreatic beta cell function

Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease conditions. In pancreatic beta cells, miRNAs have been largely unstudied and little is known about how specific miRNAs regulate glucose-stimulated insulin secretion (GSIS) or impact the adaptation of beta cell function to metabolic stress. In t

Climate and Food Production: Understanding Vulnerability from Past Trends in Africa's Sudan-Sahel

Just how influential is rainfall on agricultural production in the Sudan-Sahel of Africa? And, is there evidence that support for small-scale farming can reduce the vulnerability of crop yields to rainfall in these sensitive agro-ecological zones? These questions are explored based on a case study from Cameroon's Sudan-Sahel region. Climate data for 20 years and crop production data for six major

Population Landscape of Familial Cancer.

Public perception and anxiety of familial cancer have increased demands for clinical counseling, which may be well equipped for gene testing but less prepared for counseling of the large domain of familial cancer with unknown genetic background. The aim of the present study was to highlight the full scope of familial cancer and the variable levels of risk that need to be considered. Data on the 25

Antimicrobial peptide dendrimer interacts with phosphocholine membranes in a fluidity dependent manner: a neutron reflection study combined with molecular dynamics simulations.

The interaction mechanism of a novel amphiphilic antimicrobial peptide dendrimer, BALY, with model lipid bilayers was explored through a combination of neutron reflection and molecular dynamics simulations. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dipalmitoyl-sn-glycero-3-phos-phocholine (DPPC) lipid bilayers were examined at room temperature to extract information on the in

Poor Reproducibility of Allergic Rhinitis SNP Associations

Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese po