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BackgroundBacteroides fragilis is the most frequent cause of anaerobic bacteraemia. Although recent data suggest a rise in antimicrobial resistance (AMR) of this and other anaerobic bacteria, surveillance remains limited due to a lack of both data availability and comparability. However, a newly introduced standardised method for antimicrobial susceptibility testing (AST) of anaerobic bacteria has

The public sphere is a key geographic dimension of struggles for democracy, and democratic life more broadly. Yet, the notion of a public sphere is often treated as a spatial metaphor for diffuse conversations. Drawing on critical geographies of social movements as makers of public places, we in this paper turn to the case of the early Swedish labor movements’ several hundred so-called People’s PaThe public sphere is a key geographic dimension of struggles for democracy, and democratic life more broadly. Yet, the nation of a public sphere is aften treated as a spatial metaphor for diffuse conversations. Drawing on critical geographies of social movements as makers of public places, we in this paper turn to the case of the early Swedish labor movements' several hundred so-called People's Pa

Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programs are being increasingly emphasized. Once broadly implemented, screening initiatives will identify significant numbers of islet autoantibody-positive (IAb+) child

Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programmes are being increasingly emphasised. Once broadly implemented, screening initiatives will identify significant numbers of islet autoantibody-positive (IAb+) chi

Mutations in GBA1 cause Gaucher disease and are the most important genetic risk factor for Parkinson’s disease. However, analysis of transcription at this locus is complicated by its highly homologous pseudogene, GBAP1. We show that >50% of short RNA-sequencing reads mapping to GBA1 also map to GBAP1. Thus, we used long-read RNA sequencing in the human brain, which allowed us to accurately quantif

Introduction: Reporting of hypoglycaemia and its impact in clinical studies is often retrospective and subject to recall bias. We developed the Hypo-METRICS app to measure the daily physical, psychological, and social impact of hypoglycaemia in adults with type 1 and insulin-treated type 2 diabetes in real-time using ecological momentary assessment (EMA). To help assess its utility, we aimed to de

Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challeng

Background and purpose — Reduced range of motion (ROM) and spasticity are common secondary findings in cerebral palsy (CP) affecting gait, positioning, and everyday functioning. These impairments can change over time and lead to various needs for intervention. The aim of this study was to analyze the development path of the changes in hamstring length, knee extension, ankle dorsiflexion, and spast

Myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MRTFA, and MRTF-B/MRTFB) suppress production of pro-inflammatory cytokines and chemokines in human smooth muscle cells (SMCs) through sequestration of RelA in the NF-κB complex, but additional mechanisms are likely involved. The cGAS-STING pathway is activated by double-stranded DNA in the cytosolic compartment and acts throug

Finns det sätt att forska som är queer- eller transfeministiska? Det korta svaret är nej. Och ja. Och nej igen. Jag landar i ett rungande nja. Och försöker utforska frågan med fler frågor: När anser vi att en studie är trans eller queer? Gäller det forskningsfrågorna? Deltagarna? Teorierna? Forskarens position? Eller just metoderna? Med denna text vill jag bekräfta dig som är nyfiken på att bedriv

In this text, I analyze the role of gender-sex-sexuality in school policies in Sweden, Canada, and Germany. Policies concerning young people’s negotiations of gender-sex-sexuality in schools draw on specific understandings of societal belonging and cohesion. Invariably such policies are part of national discourses regarding values and norms of gender and relationships, informed by concepts of ethn

Flash droughts, as sub-seasonal phenomena, are characterized by their rapid onset and significant impact on terrestrial ecosystems. However, understanding how vegetation responds to flash droughts and the mechanisms governing vegetation recovery remains elusive. Here, we analysed the response of vegetation productivity to flash droughts and identified the most relevant drivers controlling vegetati

Objective: Powered mobility offers young children the opportunity to explore their world, develop awareness of their environment, and actively participate in play and daily activities. It enables children with severe disabilities to experience equity and equality by increasing their mobility. Powered mobility devices not only provide means for movement but also enhance children's understanding of