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The Ordovician Period includes two major macroevolutionary events: the Great Ordovician Biodiversification Event (GOBE) and the Late Ordovician Mass Extinction (LOME), alongside a fundamental climate transition from a greenhouse to an icehouse state. Although both biological events occurred during relatively short-term global cooling conditions, their starkly contrasting biotic responses remain po
In recent years, weather-related extreme events have shown the limits of technical approaches to urban water challenges and highlighted the urgent need to rethink the relationship between cities and water and to see water as a partner in shaping transformative, climate-safe and just urban futures. However, existing scientific studies depicting future trajectories of urban water management have str
An assessment of the global progress in climate change adaptation is urgently needed. Despite a rising awareness that adaptation should involve diverse societal actors and a shared sense of responsibility, little is known about the types of actors, such as state and non-state, and their roles in different types of adaptation responses as well as in different regions. Based on a large n-structured
Nature-based solutions (NBS) have emerged as an important concept to build climate resilience in cities whilst providing a wide range of ecological, economic, and social co-benefits. With the ambition of increasing NBS uptake, diverse actors have been developing means to demonstrate and prove these benefits. However, the multifunctionality, the different types of benefits provided, and the context
Platinum electrodes are of key importance in electrocatalysis due to their high activity for the hydrogen evolution and oxygen reduction reactions. Industrially-relevant Pt electrodes typically exhibit significant surface heterogeneity ( i.e. , poly-/nanocrystallinity), complicating the establishment of clear relationships between structure and electrochemical properties. To unravel the influence
Given the contested nature of urban futures, we approach the term “transition” as a floating signifier to investigate imaginaries of transformation. Focusing on urban mobility transitions, we demonstrate the plurality of associations with a post-transition future. This perspective allows the identification of underlying tensions and incommensurabilities between competing visions of the future. Q m
Objective To determine if familial diabetes burden across multiple kinship levels is associated with hospital-diagnosed COVID-19 in a population-based cohort. Methods We analyzed data from 15,516 participants in the Malmö Diet and Cancer Study (MDCS), a prospective, population-based cohort in southern Sweden. Familial burdens among first-degree relatives (parents, siblings, children) of diabetes,
Post-translational modifications (PTMs) such as nitration of Tyr (Y) residues and di-tyrosine (DT) formation are known to impact the aggregation behavior of α-synuclein (α-syn), a protein closely linked to Parkinson's disease. Using tetranitromethane (TNM) as a model nitrating agent, we systematically investigated the chemical modifications of α-syn and their consequences for aggregation. Mass spe
Inom EU pågår arbete för att skydda viktiga naturområden bl.a. genom s.k. LIFE projekt (se t.ex. Eldridge m.fl. 2007). Därmed kan EU bidra med ekonomiskt stöd till biotop-vård, t.ex. upprätthållande av betesdriften på strandängarna, vilket bl.a. skedde genom projektet LIFE-BaltCoast (2007 – 2011) (http://www.life-balt-coast.eu/). Natura 2000-om-rådena skall samtidigt göras tillgängliga för turism.
Accurate triage of ovarian masses is facilitated in many centers by the guideline-endorsed, extensively validated IOTA-ADNEX risk model, yet the model still relies on manual measurements of key tumor features. We developed ADNEX-AI, a multi-task deep-learning system that automatically segments four ADNEX ultrasound predictors – lesion, locules, solid tissue, papillary projections – and outputs the
The Cox Proportional Hazards (CPH) model has long been the preferred survival model for its explainability. However, to increase its predictive power beyond its linear log-risk, it was extended to utilize deep neural networks, sacrificing its explainability. In this work, we explore the potential of self-explaining neural networks (SENN) for survival analysis. We propose a new locally explainable
We have previously found using questionnaire/interview data on COVID-19 outcomes, that most subjects with severe alpha-1-antitrypsin deficiency (AATD) exhibit mild COVID-19 infection and those who additionally have COPD are at increased risk of severe COVID-19. We used objective information on COVID-19 outcomes in severe AATD (PiZZ) from the Swedish population and compared the risk of severe COVID
PURPOSE: Provision of adequate support is much needed to secure equal educational opportunities for students with developmental language disorder (DLD). Important perspectives on support provision and its impact on academic progress are held by school professionals, caregivers, and students with DLD. This study sought to further the current knowledge on the perceived relation between educational s
Projecting El Niño-Southern Oscillation responses to future climate change are hindered by limited paleoclimate records spanning past abrupt climate transitions. This study combines multi-proxy records from the Northwest Borneo Trough over the past 30 kyr with transient climate simulations, reconstructing tropical western Pacific hydroclimate during Heinrich events and Bølling–Allerød warming. Res
Highly oxygenated organic molecules (HOM) play a crucial role in the formation and growth of atmospheric particles, thereby influencing air quality and climate. A comprehensive understanding of HOM formation, particularly an accurate quantification of their yields, is essential to constrain the climate and health impacts of aerosols. Previous studies often reported constant HOM yields as averages,
A search is conducted for a new scalar boson S, with a mass distinct from that of the Higgs boson, decaying promptly into four leptons (ℓ=e, μ) via an intermediate state containing two on-shell, promptly decaying new spin-1 bosons Zd: S→ZdZd→4ℓ, where the Zd boson has a mass between 15 and 300 GeV, and the S boson has a mass between either 30 and 115 GeV or 130 and 800 GeV. The search uses proton–
This paper presents findings from a transdisciplinary study exploring conditions for Inclusive Science Education (ISE) for children aged 0–16 from communities in vulnerability risk situation. A two-step literature review was conducted to identify inclusive teaching and learning interventions. The first phase applied a Scoping Review, followed by an Integrative Literature Review focusing on communi
Background: Cardiac arrest (CA) is a major cause of mortality and morbidity. Accurate prediction of neurological outcome and survival remains challenging. In this context, our study aimed to explore novel molecular biomarkers that could provide additional insights into the pathophysiology of brain injury after CA and potentially distinguish patients with no brain injury (CPC 1) from those with any
A search for the production of three massive vector bosons, VVZ(V=W,Z), in proton–proton collisions at s=13 TeV is performed using data with an integrated luminosity of 140 fb−1 recorded by the ATLAS detector at the Large Hadron Collider. Events produced in the leptonic final states WWZ→ℓνℓνℓℓ (ℓ=e,μ), WZZ→ℓνℓℓℓℓ, ZZZ→ℓℓℓℓℓℓ, and the semileptonic final states WWZ→qqℓνℓℓ and WZZ→ℓνqqℓℓ, are analyse
