Objectives/Hypothesis: TNM-classification inadequately estimates patient-specific overall survival (OS). We aimed to improve this by developing a risk-prediction model for patients with advanced larynx cancer. Study Design: Cohort study. Methods: We developed a risk prediction model to estimate the 5-year OS rate based on a cohort of 3,442 patients with T3T4N0N+M0 larynx cancer. The model was inte

The incidence of pancreatic cancer is leveling between sexes. Smoking, high age and heredity are established risk factors, but evidence regarding the influence of hormonal factors is unclear. In this study, we investigated the associations of reproductive factors, use of oral contraceptives (OC) and hormone replacement therapy (HRT) with pancreatic cancer risk in the Malmö Diet and Cancer Study, a

Efficacy of human papillomavirus (HPV) vaccines promises to control HPV infections. However, HPV vaccination programs may lay bare an ecological niche for non-vaccine HPV types. We evaluated type-replacement by HPV type and vaccination strategy in a community-randomized trial executed in HPV vaccination naïve population. Thirty-three communities were randomized to gender-neutral vaccination with A

Geospatial data are increasingly available nowadays, and this leads to more analyses and visualisation of geospatial data from several sources. To enable this, we need homogenous data as well as proper integration methods. Geospatial data integration has been a longstanding research topic for decades, and this paper discusses the utilisation of Linked Data technology stack to alleviate the geospat

The functional equivalence of Pax6/eyeless genes across distantly related animal phyla has been one of central findings on which evo-devo studies is based. In this study, we show that Pax4, in addition to Pax6, is a vertebrate ortholog of the fly eyeless gene (and its duplicate, twin of eyeless [toy] gene, unique to Insecta). Molecular phylogenetic trees published to date placed the Pax4 gene outs

Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)

The combined quantum mechanical (QM) and molecular mechanical (MM) approach (QM/MM) is a popular method to study reactions in biochemical macromolecules. Even if the general procedure of using QM for a small, but interesting part of the system and MM for the rest is common to all approaches, the details of the implementations vary extensively, especially the treatment of the interface between the

Leadership scholars are beginning to understand leadership as a distributed phenomenon, produced in interaction and emerging in social situations. Although this perspective has contributed to understanding leadership processes in more detail, it has also been noted that its proponents have largely neglected power and asymmetrical hierarchical relations. In this paper, I address these issues by dra

The swelling of ionic microgel particles is investigated at a wide range of concentrations using a combination of light, X-ray and neutron scattering techniques. We employ a zero-average contrast approach for small-angle neutron scattering experiments, which enables a direct determination of the form factor at high concentrations. The observed particle size initially decreases strongly with the pa

The present study investigates the use of gestures by 18-, 24- and 30-month-old Swedish children, as well as their practical actions in coordination with verbs. Previous research on connections between children’s verbs and gestures has mainly focused only on iconic gestures and action verbs. We expand the research foci in two ways: we look both at gestures and at practical actions, examining how t

Målsättningar för och behov av hållbara transporter i städer är idag ett etablerat område inom trafik- och samhällsplaneringen och ökad cykling har sedan många år varit högt prioriterat av politiker och planerare. Trots dessa ambitioner har cyklingen i stället minskat på många håll under senare år. Det finns alltså ett stort behov av att identifiera och utveckla strategier och åtgärder som främjar

vilket påverkar hur vi ser på hållbarhetsaspekter vid planering av städer och i förlängningen enskilda bygg- och anläggningsprojekt. Detta medför att bygg- och fastighetsföretags sociala ansvarstagande blir en alltmer relevant del av verksamheten, inte minst vad gäller upphandling av entreprenörer och konsulter där det läggs en större vikt avseende sociala aspekter än tidigare.Trafikverkets upphan

Monitoring long-term biomass dynamics in drylands is of great importance for many environmental applications including land degradation and global carbon cycle modeling. Biomass has extensively been estimated based on the normalized difference vegetation index (NDVI) as a measure of the vegetation greenness. The vegetation optical depth (VOD) derived from satellite passive microwave observations i

Woody plants play a major role for the resilience of drylands and in peoples' livelihoods. However, due to their scattered distribution, quantifying and monitoring woody cover over space and time is challenging. We develop a phenology driven model and train/validate MODIS (MCD43A4, 500 m) derived metrics with 178 ground observations from Niger, Senegal and Mali to estimate woody cover trends from