We develop and validate diffuse optical tomography methods based on interstitial fluorescence measurements for the reconstruction of fluorescent photosensitizing drug spatial distribution. We propose another phase in the tomographic reconstruction algorithm resulting in quantitatively more accurate reconstruction. This quantitative information can be used to monitor the temporal evolution of the p

This thesis offers a cultural analysis of climate change, modernisation and sustainable development in the pastoral landscape of Baringo, Northern Kenya. For the majority of the pastoralists living there, life is defined by crippling poverty, ethnic violence and an increasingly erratic and unpredictable climate. In response, a growing number of people have moved away from the traditional reliance

We investigate how the anchoring effect—a well-established cognitive bias—influences the full distribution of subjective beliefs. While prior research extensively examines the impact of anchoring and other biases on point estimates, their effect on higher moments of the distribution remains unexplored. Through a pre-registered online experiment (N=732), we find that anchoring impacts the mean, var

Background: Efficacy of tumour necrosis factor inhibitors (TNFi) for peripheral arthritis in patients with psoriatic arthritis (PsA) has been established in randomized clinical trials that have used improvement in summated joint counts as an outcome. Whether joints at different anatomical locations might respond differentially to TNFi remains unknown. The aim of the study was to investigate potent

This study investigates how reduced visibility due to wildfire smoke affects driving behaviour, specifically speed and headway, and the resulting implications for evacuation management and planning. Data were collected from participants immersed in a virtual environment through a driving simulator with a head-mounted display. Thirty-seven participants drove through scenarios simulating a rural hig

The visual complexity of a habitat can play a significant role in the outcome of interactions between predators and prey. We currently assume that predators should maximize their foraging success by foraging in habitats where prey are easier to detect and search times are lower. Mesopredators, however, have to detect prey (as a predator) while also avoiding detection by their own predators (as pre

The chaperone DNAJB6b (JB6) plays important roles in increasing amyloid protein solubility and inhibiting amyloid fibril formation, a causative factor for neurodegenerative diseases like Alzheimer's and Parkinson's disease. Insights into the biophysical properties of JB6, including its structure, self-assembly and stability towards denaturation, may enhance the understanding of the physicochemical

Suppose an act of caring can be at once good, even admirable, and still help sustain a system that harms people and our shared world. In this paper, I reflect on interviews with street-level bureaucrats working with civil society to maintain and repair collective capacities for problem-solving and collective reflection in segregated Swedish cities. I want to explore how seeing their work as a form

Background: While energy communities working on electricity provision have been extensively studied, thermal energy communities (TECs) focusing on bringing district heating (DH) systems to decarbonise heat systems in buildings have been relatively under-researched. This study addresses this gap by presenting the first comprehensive examination of key factors influencing the emergence and developme

Whether monetary incentives to change behavior work and how they should be structured are fundamental economic questions. We overcome typical data limitations in a large-scale field experiment on vaccination (N = 5,324) with a unique combination of administrative and survey data. We find that guaranteed incentives of $20 increase uptake by 13 percentage points in the short run and 9 in the long ru

Local climate adaptation is constrained and steered along specific paths by various mechanisms, which together form a lock-in. The study focuses on Swedish local civil servants’ strategies to deal with climate adaption lock-ins and to what extent the strategies disrupt the lock-ins. Interviews were conducted with civil servants in six municipalities, complemented by inter-views at regional and nat

Purpose: To compare treatment utilisation for osteoarthritis (OA) and satisfaction with OA management between individuals with and without comorbid metabolic conditions (e.g., diabetes, obesity, dyslipidaemia, hypertension). Methods: Secondary analysis of a cross-sectional international survey study (Italy, Russia, Sweden) on people ≥ 40 years old with knee/hip OA. Metabolic comorbidity was self-r

Competitive pressure is an important driving factor of corporate behavioural changes. Yet, it is still unclear how it influences corporate attitudes towards environmental challenges. In this study, we systematically analyse the sustainability behaviour of a global sample of publicly traded firms to examine if and how competitive pressure pushes firms to implement effective behavioural changes to r

Nowadays organisms encounter not only natural challenges from predators but also significant anthropogenic stressors, such as insecticides, which can profoundly disrupt their normal growth and behavior. However, the knowledge on their potential interactions remains largely unknown, particularly regarding how insecticides may affect predator-prey interactions and prey responses across multiple gene

Grain coarsening inhibition in hard metals is regarded as controlled by formation of interface complexions. To date, however, direct experimental insights into the presence and evolution of interface complexions during sintering of hard metals have been lacking. We here present in-situ small-angle neutron scattering (SANS) experiments up to 1500 °C and provide first-hand evidence on the thickness

Background: Disease-modifying therapies targeting the diverse pathophysiology of Alzheimer’s disease (AD), including neuroinflammation, represent potentially important and novel approaches. The glucagon-like peptide-1 receptor agonist semaglutide is approved for the treatment of type 2 diabetes and obesity and has an established safety profile. Semaglutide may have a disease-modifying, neuroprotec