Background: Behavioural variant Frontotemporal Dementia (bvFTD) is an early-onset dementia characterised by early anterior cingulate (AC) neuropathological insult. The AC exhibits high morphological heterogeneity, which may be classified according to the presence of a paracingulate sulcus (PCS), a tertiary sulcus that, when present, develops during the third gestational trimester and thereafter re

Alcohol impairs motor performance, but it remains unclear precisely why this is the case. Here, we examine the effects of alcohol intoxication on conditioned eyeblink responses, a form of classical conditioning dependent on the cerebellum. In experiment 1, the conditioned responses of 18 students before and after alcohol consumption up to 1 ‰ were compared against the performance of 26 non-drinkin

Utfallet av parlamentsvalen i Europa får troliggen större påverkan på Sverige än Trump, skriver Fredrik N G Andersson, docent i nationalekonomi vid Lunds universitet.

Coherent diffractive imaging experiments often collect incomplete datasets containing regions that lack any measurements. These regions can arise because of beamstops, gaps between detectors, or, in tomography experiments, a missing wedge of data due to a limited sample rotation range. We describe practical and effective approaches to mitigate reconstruction artifacts by bringing uniqueness back t

new species can form through hybridization between species. Hybrid speciation in animals has been intensely debated, partly because hard evidence for the process has been difficult to obtain. Here we report the discovery of a European hybrid butterfly lineage, a finding that can be considered surprising given the intense and long-term study of European butterflies. The lineage we describe is main

SUMMARY: PopGLen is a Snakemake workflow for performing population genomic analyses within a genotype-likelihood framework, integrating steps for raw sequence processing of both historical and modern DNA, quality control, multiple filtering schemes, and population genomic analysis. Currently, the population genomic analyses included allow for estimating linkage disequilibrium, kinship, genetic div

Aim: This study aimed to develop a universally applicable core set of quality indicators for Hirschsprung's disease care through a consensus-driven process, to standardise and improve care quality across Europe. Methods: A modified Delphi method was used to achieve consensus among healthcare professionals (HPs) and patient representatives (PRs) across Europe. Participants completed three rounds of

Multilingual students writing in English as a foreign/second language has been a major topic in research for many years (see Leung & Valdés for overview). This topic is particularly relevant in Sweden, as reports suggest that students who are speakers of a language other than Swedish (LOTS) in the home have a lower grade average after 9 years of compulsory schooling (Skolinspektionen, 2010; Sk

Serum Amyloid A (SAA) proteins are acute-phase reactants with critical roles in sterile and bacterial inflammation. Through in vitro and in vivo experiments, we demonstrate that SAA proteins amplify cytokine and chemokine responses during sterile inflammation and enhance bacterial clearance in infectious conditions. Mechanistically, SAA proteins augment NF-κB signaling, driving pro and anti-infl

The production of 5-hydroxymethylfurfural (HMF) is an important process for a future sustainable plastic industry. Hence many processes were developed to produce HMF, however, HMF recovery and solvent recyclability are limiting steps for the process development. Therefore, In this study, granulated activated carbon (GAC) was investigated as a purification step of HMF produced from fructose in a bi

Många EU-länder kämpar med svaga offentliga finanser och i stora euroländer som Frankrike och Italien är den offentliga skulden över 100 procent av BNP. Trots strikta finanspolitiska regler har få länder lyckats hålla sina statsfinanser i schack – inte ens Tyskland. År 2024 reviderades reglerna i förhoppningen att det skall leda till mer robusta offentliga finanser i framtiden. Frågan är: löser de

The Aβ42/Aβ40 ratio in the cerebrospinal fluid (CSF) and the concentrations of neurofilament light (NfL) and total tau (t-tau) are changed in the early stages of Alzheimer’s disease (AD)1, but their neurobiological correlates are not entirely understood. Here, we used 5xFAD transgenic mice to investigate the associations between these CSF biomarkers and measures of cerebral Aβ, including Aβ42/Aβ40

Aims. Chronotropic incompetence and impaired heart rate (HR) recovery are related to mortality. Guidelines lack specific reference values for HR recovery. We defined normal values and studied blunted HR response and recovery and mortality risk. Methods and results. We included 9917 subjects (45% females) aged 18–85 years who performed a cycle exercise test. We defined normal values for peak HR, HR

The traditional Talmian binary typology of satellite-framed vs. verb-framed languages has proven to be insufficient for showing the diversity across the world’s languages. One approach within post-Talmian motion typology follows Holistic Spatial Semantics, which has been applied to languages like Swedish, French, Thai and Telugu, but not to Slavic languages. This motivates the present research. We

Background: Myocardial fibrosis, expressed as late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), is an important risk factor for malignant cardiac events in hypertrophic cardiomyopathy (HCM). However, CMR is not easily available, expensive, also needing intravenous access and contrast. Objective: To determine if derived vectorcardiographic spatial QRS-T angles, an aspec

Metastatic breast cancer (MBC) is generally considered an incurable disease and even though new treatments are available, the median survival is approximately three years. The introduction of immune therapies for MBC highlights the importance of the immune system in cancer progression and treatment. CD163+ anti-inflammatory myeloid cells, including tumor associated macrophages (TAMs), are known to

Although it is widely recognized that leadership concerns organizing future actions and mobilizing organizational actors to pursue them, our understanding of how this is accomplished in situated work interactions is relatively limited. Recent ethnographic studies have focused on leadership work resulting in the emergence of direction. This study explores the efforts involved in attempting to mobilAlthough it is widely recognized that leadership concerns organizing future actions and mobilizing organizational actors to pursue them, our understanding of how this is accomplished in situated work interactions is relatively limited. Recent ethnographic studies have focused on leadership work resulting in the emergence of direction. This study explores the efforts involved in attempting to mobil

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