Understanding, predicting, and controlling the phenotypic consequences of genetic and environmental change is essential to many areas of fundamental and applied biology. In evolutionary biology, the generative process of development is a major source of organismal evolvability that constrains or facilitates adaptive change by shaping the distribution of phenotypic variation that selection can act

Objective: The aim of the study was to investigate if time to start chemotherapy (TTC) after primary debulking surgery (PDS) impacted relative survival (RS) in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer (EOC). Methods: Nationwide population-based study of women with EOC FIGO stages IIIC-IV, registered 2008–2018 in the Swedish Quality Register for Gynecologic Cancer, treat

Objective. To evaluate patient-reported outcomes (PROs) after initiation of tumor necrosis factor inhibitor (TNFi) treatment in European real-world patients with psoriatic arthritis (PsA). Further, to investigate PRO remission rates across treatment courses, registries, disease duration, sex, and age at disease onset. Methods. Visual analog scale or numerical rating scale scores for pain, fatigue,

We call a number representable by some given integers $a_1,\dots,a_n$, if the number can be expressed as a linear combination of $a_1,\dots,a_n$ with non-negative coefficients. This thesis explores the properties of non-representable numbers, with the main focus on the greatest such number called the Frobenius number, denoted by $g(a_1,\dots,a_n)$. We derive a simple formula when $n=2$ for the Fro

As Hamas comes into the public eye because of their attack on Israel and their civilians on 7th October 2023 so does the question on what Hamas is. Are they a resistance movement? Or are they a terrorist organization as some countries deem them? Are they something else entirely? This paper examines their original charter from 1988 through a rhetorical framework of Stephen D. O’Leary’s apocalyptic

A note with instructions for teaching the case with the same title.

The case presents Aboke-pesa, a local complementary currency in a poor rural area of Western Kenya.The reader gets an insight into the economic context of rural areas in the Global South, the work of introducing digital community currencies through farmers’ cooperatives, one of the most common designs of these currencies (mutual credit systems or LETS) as well as the particular challenges digital

Syftet med detta bidrag är alltså att kritiskt granska äldres rätt till fri rörlighetinom EU. Utgångspunkten för denna analys är artikel 3 FEU där centralavärden för EU såsom välfärd, fri rörlighet, icke-diskriminering, socialrättvisa, socialt skydd och jämställdhet mellan kvinnor och män betonas.Vårt bidrag i detta kapitel är att visa att såsom reglerna är utformade idagriskerar de att ha en kraf

Van Hove singularities (VHss) in the vicinity of the Fermi energy often play a dramatic role in the physics of strongly correlated electron materials. The divergence of the density of states generated by VHss can trigger the emergence of phases such as superconductivity, ferromagnetism, metamagnetism, and density wave orders. A detailed understanding of the electronic structure of these VHss is th

We have investigated the optical properties of heterostructured InGaN platelets aiming at red emission, intended for use as nano-scaled light-emitting diodes. The focus is on the presence of non-radiative emission in the form of dark line defects. We have performed the study using hyperspectral cathodoluminescence imaging. The platelets were grown on a template consisting of InGaN pyramids, flatte

Experimental tests of Cross Laminated Timber (CLT) under in-plane beam loading conditions are presented. The influence of the element layup, the individual lamination width, and the beam overhang at the supports on the shear force capacity was investigated. All the CLT beams had the same gross cross section, and a 4-point-bending test setup was used. The experimentally determined load-bearing capa

Due to large losses of seagrass meadows worldwide, restoration is proposed as a key strategy for increasing coastal resilience and recovery. The emergence of a seagrass meadow is expected to substantially amplify biodiversity and enhance benthic metabolism by increasing primary productivity and respiration. Nevertheless, open questions remain regarding the metabolic balance of aging seagrass meado

Drug-induced hepatotoxicity constitutes a major reason for non-approval and post-marketing withdrawal of pharmaceuticals. In many cases, preclinical models lack predictive capacity for hepatic damage in humans. A vital concern is the integration of immune system effects in preclinical safety assessment. The immune-related Adverse Outcome Pathway (irAOP) approach, which is applied within the Immune

Using Euryale ferox husk as raw material, pristine biochar (EBC), Bi2MoO6-modified biochar (BM-EBC), and BiFeO3-modified biochar (BF-EBC) were prepared and employed for decontaminating Congo red (CR) from wastewater. Compared with EBC (217.59 mg/g) and BF-EBC (359.49 mg/g), a superior adsorption capacity of 460.77 mg/g was achieved by BM-EBC. Based on the evaluation results of the Freundlich and p

In translational research, there is a need for preclinical studies of high quality that corresponds to the conformal dose distributions conventionally delivered to humans in the modern radiotherapy clinic. To facilitate this need, novel preclinical systems consist of preclinical radiation platforms and small animal treatment planning systems. However, small-field dosimetry is challenging and requi

A cross-valley beach terrace in Iladalen in the south-eastern corner of Barentsøya (Svalbard) is interpreted as built by long-shore sediment transport and deposition, with its maximum height at 88 m a.s.l., marking the marine limit (ML) at deglaciation. A whale vertebra (most probably from a bowhead whale, Balaena mysticetus) was found embedded in the upper part of the littoral sediments at a hei

Första delen i denna avhandling fokuserar på 'Imaging Mass Spectrometry' (IMS), en analytisk teknik med kartografiska egenskaper. Denna teknik används dock inte för att kartlägga geografiska terränger, utan för att skapa kartor över det kemiska landskapet i biologiska prover, från vävnadssnitt av organ eller tumörer till enskilda celler. Dessa kartor visar med hög precision var olika molekyler, såThe development of imaging technologies and brain models is crucial for advancements in neurotherapeutic drug discovery and development. They assume a critical role in evaluating essential parameters such as drug blood-brain barrier (BBB) permeation, distribution, and metabolism, all of which are vital for the development of safe and effective medications. In the first part of this thesis, we expl