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Effect of Calcineurin Inhibitor-Free Everolimus-Based Immunosuppressive Regimen on Albuminuria and Glomerular Filtration Rate after Heart Transplantation

BACKGROUND: Albuminuria in maintenance heart transplantation (HTx) is associated with poor renal response when switching to a calcineurin inhibitor (CNI)-lowered or free immunosuppressive regimen using everolimus (EVR), but the significance of albuminuria associated with EVR treatment after early CNI withdrawal in de novo HTx is unknown. METHODS: We tested if glomerular filtration rate (mGFR, meas

Optimal Epinephrine Concentration and Time Delay to Minimize Perfusion in Eyelid Surgery : Measured by Laser-Based Methods and a Novel Form of Extended-Wavelength Diffuse Reflectance Spectroscopy

OBJECTIVE:: This study investigates the hypoperfusion effects of epinephrine in local anesthesia in eyelid surgery. A novel form of extended-wavelength diffuse reflectance spectroscopy was evaluated. METHODS:: Blood perfusion in porcine eyelid flaps was measured using laser Doppler velocimetry and laser speckle contrast imaging, whereas the tissue response was measured using diffuse reflectance sp

Left and right ventricular hemodynamic forces in healthy volunteers and elite athletes assessed with 4D flow magnetic resonance imaging

Intracardiac blood flow is driven by hemodynamic forces that are exchanged between the blood and myocardium. Previous studies have been limited to 2D measurements or investigated only left ventricular (LV) forces. Right ventricular (RV) forces and their mechanistic contribution to asymmetric redirection of flow in the RV have not been measured. We therefore aimed to quantify 3D hemodynamic forces

A radial head prosthesis appears to be unnecessary in Mason-IV fracture dislocation

Background and purpose — Previous reports on elbow injuries with concomitant comminute radial head fracture are difficult to interpret, since they include an array of different soft-tissue and bony injuries around the elbow. We focused on Mason-IV fracture dislocations of the elbow and retrospectively reviewed 2 treatment options: radial head resection or replacement with a radial head arthroplast

Priming Language Political Issues as Issues of State Security : A Corpus-Assisted Discourse Analysis of Language Ideological Debates in Estonian Media Before and After the Ukrainian Crisis

Soon after the annexation of Crimea by the Russian Federation in March 2014, a peak moment in the events commonly referred to as the Ukraine crisis (Wilson A, Ukraine crisis. What it means to the West? Yale University Press, New Haven, 2014), media in Estonia and abroad started to speculate about whether Russia would stop at Crimea, or if Estonia, with its sizable Russian-speaking minority, would

Coupling between creep and redox behavior in nickel - yttria stabilized zirconia observed in-situ by monochromatic neutron imaging

Ni-YSZ (nickel - yttria stabilized zirconia) is a material widely used for electrodes and supports in solid oxide electrochemical cells. The mechanical and electrochemical performance of these layers, and thus the whole cell, depends on their microstructure. During the initial operation of a cell, NiO is reduced to Ni. When this process is conducted under external load, like also present in a stac

Riskhanteringsprocessen och flödessäkerheten

I denna publikation karakteriseras riskhanteringsprocessen som bestående av 14 olika steg och varje steg beskrivs och diskuteras. Även utvidgade aspekter på riskhanteringsprocessen samt riskhanteringens ekonomiska betydelse behandlas.Dagens moderna samhälle är ett i många avseenden sårbart samhälle till stor del uppbyggt kring försörjningskedjor (supply chains). I dessa hårt integrerade kedjor med

Försörjningskedjans framväxt och framtid

Dagens moderna samhälle är ett i många avseenden sårbart samhälle. Det har inte varit någon medveten strävan utan är en konsekvens av att samhället till stor del kommit att bli uppbyggt kring försörjningskedjor (supply chains). I dessa hårt integrerade kedjor med ett flertal ofta globalt utspridda led flyter en ständig ström av fysiska varor, tjänster samt kombinationer av varor och tjänster.I den

Three-dimensional functional human neuronal networks in uncompressed low-density electrospun fiber scaffolds

We demonstrate an artificial three-dimensional (3D) electrical active human neuronal network system, by the growth of brain neural progenitors in highly porous low density electrospun poly-ε-caprolactone (PCL) fiber scaffolds. In neuroscience research cell-based assays are important experimental instruments for studying neuronal function in health and disease. Traditional cell culture at 2D-surfac

Detector Development, Source Characterization and Novel Applications of Laser Ion Acceleration

The main focus of the work presented in this thesis is on experimental studies oflaser acceleration of protons and other positive ions from solid targets. The topic is explored from three different angles: firstly, the development of diagnostics adapted to the ion pulses, secondly, the characterization of the source of the energetic particles and, finally, the application of laser-accelerated prot

Visibility simulation of realistic grating interferometers including grating geometries and energy spectra

The performance of X-ray and neutron grating interferometers is characterised by their visibility, which is a measure for the maximum achievable contrast. In this study we show how the real grating geometry in a grating interferometer with three gratings impacts the interference and self projection that leads to visibility in the first place. We quantify the individual contributions of wavelength

Bellman Anakreon Hafiz : Gustaf Ljunggren och världslitteraturens skala

In his study of Carl Michael Bellman literary historian Gustaf Ljunggren (1823-1905) compared the Swedish poet not only to the traditional object of comnaprison, the ancient Greek poet Anacreon, but also to the Persian fourteenth-century poet Hafiz.This article revisits Ljunggren's work in light of recent discussions about world literature and the role of historical scale in literary studies. I in