In order to expand the recognition code by hairpin polyamides to include DNA sequences of the type 5′-CWWC-3′ two polyamides, PyPyPyPy-(R)H2Nγ-ImPyPyIm-β-Dp (1) and PyPyPyPy-(R)H2Nγ-ImPy-β-Im-β-Dp (2) were synthesized which have in common an Py/Im pair in the terminal position for targeting C·G but differ with respect to internal placement of a β-alanine residue. The equilibrium association consta

The aim of this thesis is to investigate how journalists at Lilla Aktuellt and Juniornyheterna are influenced by their news audience, primarily children and youths, on Tiktok. Both editorials work on behalf of Swedish public service, which means they have to report objectively and impartially. Previous research has shown that public service organizations must reassess what it means to be of public

The following bachelor thesis aims to investigate how advertising on the social media application TikTok affects attitudes, consumer behaviour and brand awareness among their users aged 18-23 in Sweden. The ambition of the study is to contribute with research on how advertising is being recieved by TikTok's users, regarding attitudes and consumer behaviour, and establishing whether it is a suc

The meat sector is a known contributor to pressing environmental and public health problems such as climate change and antimicrobial resistance. Despite this, efforts to encourage changes in meat consumption face multiple barriers. One such obstacle is the fact that the meat industry engages in lobbying efforts to influence public opinion and delay policy formation. This study aimed to identify wh

Energy transitions are at the top of global agendas in response to the growing challenges of climate change and international conflict, with the EU positioning itself as playing a pivotal role in addressing climate risks and sustainability imperatives. European energy transition policies identify ‘smart consumption’ as a key element of these efforts, which have previously been explored from a pred

In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming. However, the biological significance of this mechanism in vivo remains unclear. Here, we address mitotic retention of the hemogenic factors GATA2, GFI1B and FOS during haematopoietic specifica

In secondary-school English-as-a-foreign-language (EFL) classrooms worldwide, English tends to be used alongside the society or community majority language (Brevik & Rindal 2020; Tsagari & Diakou 2015; Üstünel 2016), and research reveals greater participation and positive attitudes among students when translanguaging is permitted (Ebe 2016; Kleyn 2016; Saxena 2009; Ollerhead 2019; Seltzer

This paper reflects on the increasing role played by algorithms in management today by situating this trend in the context of a long-standing debate about the distinction between leadership and management. Our guiding question concerns the role of humans in what might be called ‘algorithmic leadership’, understood as an advanced form of algorithmic management that is making redundant some of the e

(Trimethylsilyl)ethyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside and (trimethylsilyl)ethyl 2,3,6-tri-O-acetyl-4-O-(2,3,6-tri-O-acetyl-4-O-[2-acetamido-4,6-di-O-ace tyl-2- deoxy-3-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D- galactopyranosyl]-beta-D-galactopyranosyl)-beta-D-glucopyranoside have been transformed in high yield into the corresponding 1-O-beta-acyl saccharides by treat

Objectives:Assess the extent to which the clinical trial registration and reporting policies of 25 of the world’s largest public and philanthropic medical research funders meet best practice benchmarks as stipulated by the 2017 WHO Joint Statement, and document changes in the policies and monitoring systems of 19 European funders over the past year.Design, Setting, Participants:Cross-sectional stu

This article discusses what we call the Asymmetry Problem, a theoretical question of how asymmetric properties of prosodic phrasing should generally be accounted for within the framework of Match Theory. Unlike Alignment Theory, in which phrasing asymmetry can be derived by mapping constraints (e.g., Align-XP), Match Theory cannot derive any phrasing asymmetry from mapping (i.e., Match) constraint

Internationally, there is considerable inconsistency in the recognition and regulation of children's genetic connections outside the family. In the context of gamete and embryo donation, challenges for regulation seem endless. In this paper, I review some of the paths that have been taken to manage children' being closely genetically related to people outside their families. I do so against the ba

Humans show a population-level preference for using the right hand. The fighting hypothesis is an influential theory that suggests that left-handedness persists because its rarity provides a surprise advantage in fighting interactions, and that left-handedness is less frequent because it has a health cost. However, evidence for the health cost of left-handedness is unsubstantiated, leaving the gre

Operando powder X-ray diffraction (PXRD) is a widely employed method for the investigation of structural evolution and phase transitions in electrodes for rechargeable batteries. Due to the advantages of high brilliance and high X-ray energies, the experiments are often carried out at synchrotron facilities. It is known that the X-ray exposure can cause beam damage in the battery cell, resulting i

Local stellar motions are expected, and have been shown, to include signatures of the Galaxy’s past dynamical evolution. These are typically divided into the disc, which shows the dynamical effects of spiral arms and the bar, and the stellar halo, with structures thought to be debris from past mergers. We use Gaia Data Release 3 to select large samples of these populations without limiting them to

BACKGROUND: ACURATE neo2 is a transcatheter aortic valve implantation system consisting of a self-expanding bioprosthetic valve with supra-annular leaflet position and featuring innovations to facilitate placement accuracy and reduce paravalvular regurgitation. METHODS AND RESULTS: The goal of the Early neo2 (Early neo2 Registry of the ACURATE neo2 TAVI Prosthesis) was to gather real-life data on