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OBJECTIVE: To identify and characterize genetic loci associated with the risk of developing anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV).METHODS: Genetic association analyses were performed after Illumina sequencing of 1,853 genes and subsequent replication with genotyping of selected SNPs in a total cohort of 1110 Scandinavian cases with granulomatosis with polyangiit

OBJECTIVES: Fatigue is common and severe in primary Sjögren's syndrome (pSS). The aim of this study was to identify genetic determinants of fatigue in pSS through a genome-wide association study.METHODS: Patients with pSS from Norway, Sweden, UK and USA with fatigue and genotype data available were included. After genotype imputation and quality control, 682 patients and 4 966 157 genetic markers

Ett viktigt mål för samhället, särskilt för utbildningssystemen, är att vi människor blirbättre på att få syn på växter och på deras betydelse i ekosystemen. Vi behöver över-vinna vad som benämns ‘växtblindhet’. I denna artikel föreslår vi att variationsteoriär en bra utgångspunkt i utbildning och utvärdering av växtidentifiering inom högreutbildning. Vi redovisar exempel från svensk universitetsu

Recently, interest has been growing in investigating rhythm cognition and behavior in nonhuman animals as a way of tracking the evolutionary origins of human musicality—that is, the ability to perceive, enjoy, and produce music. During the past 2 decades, an explosion of theoretical proposals have aimed at explaining why and how humans have evolved into musical beings, and the empirical comparativ

Short-term memory is implicated in a range of cognitive abilities and is critical for understanding primate cognitive evolution. To investigate the effects of phylogeny, ecology and sociality on short-term memory ability, we tested 421 non-human primates across 41 species in a pre-registered, experimental delayed-response task. Our results confirm previous findings that longer delays decrease memo

BACKGROUND: Major depressive disorder (MDD) is one of the most common psychiatric disorders and is a great disease burden. However, its underlying pathophysiology and aetiology remain poorly understood. Available evidence suggests that circulating microRNAs (miRNAs) are associated with MDD, but it is still unknown whether miRNAs can predict subsequent incident MDD.METHODS: In this nested case-cont

BACKGROUND AND AIMS: Mitochondrial DNA copy number (mtDNA-CN) is a surrogate biomarker of mitochondrial dysfunction and is associated with type 2 diabetes (T2D) and cardiovascular disease (CVD). However, despite being associated with both CVD and T2D, it is not known what role mtDNA-CN has in the association between T2D and CVD. Our aims were to investigate whether, (1) baseline mtDNA-CN is associ

Virtue ethics has many times been suggested as a promising recipe for the construction of artificial moral agents due to its emphasis on moral character and learning. However, given the complex nature of the theory, hardly any work has de facto attempted to implement the core tenets of virtue ethics in moral machines. The main goal of this paper is to demonstrate how virtue ethics can be taken all

Det förvaltningsrättsliga landskapet i Sverige har under de senaste decennierna blivit allt mer sammanlänkat med Europarätten, dvs. EU-rätten, Europakonventionen samt annat material från Europarådet. För att som svensk jurist kunna arbeta med förvaltningsrättsliga frågor är det nödvändigt att ha en grundläggande förståelse för hur Europarätten påverkar de svenska rättsliga strukturerna. I verket p

Caustics are a challenging light transport phenomenon to render in real-time, and most previous approaches have used screen-space accumulation based on the fast rasterization hardware of GPUs. This limits the position of photon collection points to first hit screen space locations, and leads to missing caustics that should be visible in a mirror’s reflection. In this paper we propose an algorithm

Objective: The present study assessed if individuals ≥ 60 years of age with periodontitis are more likely to develop stroke or ischemic heart diseases, or at a higher risk of death for 17 years. Material and methods: At baseline individuals ≥ 60 received a dental examination including a panoramic radiograph. Periodontitis was defined as having ≥ 30% sites with ≥ 5-mm distance from the cementoename