Two experimental systems representative of the mitochondrial and death receptor apoptotic pathways are the dexamethasone-induced programmed cell death in mouse thymocytes and the antibody-mediated cross-ligation of the Fas receptor in the human leukemic T-cell line Jurkat, respectively. In both cell systems, caspase-9, -8, and -3 were activated upon induction of apoptosis and a sub-G(1) peak appea

For the analysis of small concentrations of organics in aqueous solutions, a novel add-on accessory for dual-beam / optical subtraction spectroscopy has been built for a commercial Fourier transform infrared spectrometer. A standard FT-IR instrument requires a sample measurement and a separate reference measurement, whereas the optical subtraction instrument directly measures the difference betwee

An experimental investigation has been carried out to find the pressure difference of the process of steam condensation across the port to channel in plate heat exchangers. In the present study, low corrugation angle (30 degrees) plates have been used for different number of channels, namely, 10 and 80. The process steam entered at 1 bar with a small degree of superheat. Water has been used as the

The estimated quantity of cement for construction and sealing purposes is around 9E5 kg in the planned Swedish KBS3 repository for nuclear waste. The highly alkaline cement pore fluid (pH > 12) may affect other components in the repository, and especially the bentonite buffer is of concern. In this study, we simulated possible interactions between cement and bentonite by contacting highly compacte

Diamond Blackfan anaemia (DBA) is a rare, genetically and clinically heterogeneous, inherited red cell aplasia. Classical DBA affects about seven per million live births and presents during the first year of life. However, as mutated genes have been discovered in DBA, non-classical cases with less distinct phenotypes are being described in adults as well as children. In caring for these patients i

Purpose: Tumor-Node-Metastasis classification does not fully predict outcome of treatment and prognosis in patients with squamous cell carcinoma of the head and neck. Different biomarkers have been suggested to yield additional prognostic information, but no single marker has thus far been introduced in the clinic. The objective of the present study was to analyze the copy number of the frequently

Polynomial composition is the operation of replacing the variables in a polynomial with other polynomials. In this paper we give sufficient and necessary conditions on a set $Theta$ of noncommutative polynomials to assure that the set $G circ Theta$ of composed polynomials is a Gröbner basis in the free associative algebra whenever $G$ is. The subject was initiated by H. Hong, who treated the comm

Today, the underlying theoretical and methodological foundations as well as implementations in the field of accessibility are largely based on plans, metrics and heuristics. There is an obvious tension between these norms and those of the overall spirit of the times, which leans heavily towards improvisations, diversity, and ever-changing affordances. The parallel evolution of human computer inter

Seasonal changes oi leachate production and water-flux-dependent leachate quality from two test cells containing 4,000 t of refuse each were investigated. Pronounced seasonal dependence of the leachate production appeared three years after the final covering of the test cells. With seasonal dependent production, a number of leachate parameters showed water-Aux-dependent trends. The dependence was

A method was designed for rapid and reliable demonstration of the presence of infectious pancreatic necrosis virus retrieved from 5 1 water samples. Viruses together with an added carrier protein were adsorbed to a resin of an added anion exchanger. Then the resin was collected rapidly and quantitatively through a specific device which we designed. The resin was transferred to a column from which

We report on the application of polarization spectroscopy in the midinfrared spectral region for the detection of methane by probing its asymmetric ro-vibrational transitions. Tunable infrared laser radiation, near 3.4 mum, was obtained from difference-frequency generation in a LiNbO3 crystal. Infrared polarization spectroscopy (IRPS) spectra of the P, Q and R branches of the nu(3) band, recorded

Human endogenous retroviruses (HERVs) and other long terminal repeat (LTR)–containing elements comprise a significant portion (8%) of the human genome and are likely vestiges of retroviral infections during primate evolution. Many of the HERVs present in human DNA have retained functional promoter, enhancer, and polyadenylation signals, and these regulatory sequences have the potential to modify t

An Autonomously Guided Vehicle using both odometry and visual data for navigation needs calibration parameters. These include camera placement as well as parameters relating odometry to vehicle motion. Calibration of these parameters is related to the Hand-Eye calibration problem. Instead of using a calibration target or trying to solve for structure and motion a novel method using the continuous

The tightness and integrity of all Swedish reactor containments depend directly and indirectly on the function of the post-tensioned system. The tendon force in containments with unbonded tendons is followed up at regular in-service inspections (ISI) to ensure that the remaining force is sufficient. At the inspections, the tendon force is measured with so-called lift-off technique, where a jack is

We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene. We undertook genotyping of 81 healthy young Danish men for rs7903146 of TCF7L2 and carried out various beta cell tests including: 24 h glucose, insulin and glucagon profiles; OGTT; mixed meal test; IVGTT; hyperglycaemic clamp with co-infusion of glucagon-like

Mucosal pathogens target sites of infection through specific adherence to host glycoconjugate receptors. As a consequence, depletion of such receptors from the cell surface may be expected to inhibit attachment, impair bacterial colonization and reduce the activation of mucosal inflammation. We have used the glucose analogue and glycosphingolipid (GSL) biosynthesis inhibitor N-butyldeoxynojirimyci