Telomerase maintains telomere length and chromosome integrity by adding short tandem repeats of single-stranded DNA to the 3' ends, via reverse transcription of a defined template region of its RNA subunit. To further understand the telomerase elongation mechanism, we studied the primer utilization and extension activity of the telomerase from the budding yeast Naumovozyma castellii (Saccharomyces

Ruthenium clusters containing the chiral binaphthyl-derived mono-phosphiranes [(S)-([1,1'-binaphthalen]-2-yl)phosphirane] (S)-1a, [(R)-(2'-methoxy-1,1'-binaphthyl-2-yl)phosphirane] (R)-1b, and the diphosphirane [2,2'-di(phosphiran-1-yl)-1,1'-binaphthalene] (S)-1c have been synthesized and characterized. The clusters are [(μ-H)4Ru4(CO)11((S)-1a)] (S)-2, [(μ-H)4Ru4(CO)11((R)-1b)] (R)-3, 1,1-[(μ-H)4R

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across anal

FKBP12, a small human enzyme, aids protein folding by catalyzing cis-trans isomerization of peptidyl-prolyl bonds, and is involved in cell signaling pathways, calcium regulation, and the immune response. The underlying molecular mechanisms are not fully understood, but it is well-known that aromatic residues in the active site and neighboring loops are important for substrate binding and catalysis

Particle methods such as the particle filter and particle smoothers have proven very useful for solving challenging nonlinear estimation problems in a wide variety of fields during the last decade. However, there are still very few existing tools available to support and assist researchers and engineers in applying the vast number of methods in this field to their own problems. This paper identifi

This book investigates peacebuilding in post-conflict scenarios by analysing the link between peace, space and place. By focusing on the case studies of Cyprus, Kosovo, Bosnia-Herzegovina, Northern Ireland and South Africa, the book provides a spatial reading of agency in peacebuilding contexts. It conceptualises peacebuilding agency in post-conflict landscapes as situated between place (material

Aims: To determine the differences in breastfeeding among women who did and did not experience domestic violence during pregnancy and postpartum in a Swedish context. In addition, to identify possible differences regarding breastfeeding between groups with or without a history of violence. Further, determine the relationship between exclusive breastfeeding and symptoms of depression. Background: H

A search is performed for the process pp→G*→BHb-/B-Hb→Hbb-→bb-bb-, predicted in composite Higgs scenarios, where G* is a heavy colour octet vector resonance and BH a vector-like quark of charge -1/3. The data were obtained from pp collisions at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 19.5 fb-1, recorded by the ATLAS detector at the LHC. The largest background,

The measurement of prompt D-meson production as a function of multiplicity in p-Pb collisions at sNN=5.02 TeV with the ALICE detector at the LHC is reported. D0, D+ and D∗+ mesons are reconstructed via their hadronic decay channels in the centre-of-mass rapidity range −0.96 < ycms< 0.04 and transverse momentum interval 1

The presentation is based on the theoretical model for sustainable working life for all ages (swAge). The swAge model includes the complex picture of factors and areas of importance to work life participation. In the model, different ageing concepts is related to the nine areas of importance for individuals perspective of work life participation and the four consideration areas to if individuals c

Combined ATLAS and CMS measurements of the Higgs boson production and decay rates, as well as constraints on its couplings to vector bosons and fermions, are presented. The combination is based on the analysis of five production processes, namely gluon fusion, vector boson fusion, and associated production with a W or a Z boson or a pair of top quarks, and of the six decay modes H → ZZ, W W, γγ, τ

A measurement of the Bs0decay parameters in the Bs0→ J/ψϕ channel using an integrated luminosity of 14.3 fb−1collected by the ATLAS detector from 8 TeV pp collisions at the LHC is presented. The measured parameters include the CP -violating phase ϕs, the decay width Γs and the width difference between the mass eigenstates ΔΓs. The values measured for the physical parameters are statistically combi

The aim of this paper was to explore the effect of seasonal temperature differences and cold indoor environment in winter on the physical performance of older people living in the community based on a field study. We recruited 162 home-dwelling older people from a rehabilitation facility in the Osaka prefecture, Japan; physical performance data were available from 98/162 (60.5%). At the same time,

Beundran för Maos Kina och inte minst för kulturrevolutionen betydde mycket för vänsteruppsvinget under 1960-talets senare hälft. Den växande konflikten mellan maoismen och sovjetkommunismen kom i hög grad att influera den svenska vänsterns utveckling och till sist sönderfall i olika fraktioner. Mao i Sverige följer den svenska maoismens utveckling steg för steg. Förutom att gå kronologiskt fram l