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Background: COPD management is guided by the respiratory symptom burden, assessed using the modified Medical Research Council (mMRC) scale, the COPD Assessment Test (CAT), or both. Research Question: What are the abilities of mMRC and CAT to detect abnormally high exertional breathlessness on incremental cardiopulmonary cycle exercise testing (CPET) in people with COPD? Study Design and Methods: A

Recent advances in 3D printing have enabled fabrication of architected functional ceramics with tunable functionalities at reduced weight and cost. An essential cornerstone of materials design is to determine structure–property relations. For polycrystalline ferroelectrics, such relationships can be complex due to several microscopic mechanisms, such as lattice strains and/or domain switching, whi

Lignin has emerged as a sustainable alternative to fossil-based polymers in advanced materials such as photonics. However, current methods for preparing photonic lignin materials are limited by non-benign organic solvents and low production yields. In this work, we present a highly efficient process that enables the production of photonic glasses with yields ranging from 48% to 72%, depending on t

Cryptic genetic differentiation is being increasingly documented in birds and other organisms using genome-wide variation. A recent example of cryptic genetic differentiation in a widespread species with conserved morphology is the northern house wren Troglodytes aedon. We found that, despite extremely similar morphology and no documented vocal differences, the two subspecies of the northern house

This study investigates the requirements for estimating CO2 emissions at the country scale using observational data from the Integrated Carbon Observation System (ICOS) atmosphere network, taking Italy as a case study. In particular, we explore the potential expansion of Italy’s current atmospheric ICOS network by identifying additional existing and future stations that would most effectively impr

A continental-type glacial flood termed the Suwałki megafloods took place in NE Poland during the last glaciation and significantly transformed the proglacial area. This study aims, for the first time, to establish the chronology of this flood. Twenty-two sediment samples from two meltwater spillways were dated by optically stimulated luminescence. Sixteen ages from the flood megadunes are between

The Oriental fruit moth Grapholita molesta is distributed throughout temperate regions and considered to be a pest in peach production and other high-value fruit crops in the rose family. Insecticide treatment has led to resistance development, but the use of sex pheromones in pest management has shown great promise. We investigated the pheromone biosynthesis pathway in G. molesta with the aim of

The present paper discusses the effects of social identity and self-determination theory and highlights their relevance for welfare conditionality with respect to individual behaviour and well-being. While welfare conditionality may provide economic incentives for certain desired behaviours, e.g., active job search, it is argued that their impact on the claimants’ social self-construal and identit

Traumatic brain injury is widely viewed as a risk factor for dementia, but the biological mechanisms underlying this association are still unclear. In previous studies, traumatic brain injury has been associated with the hallmark pathologies of Alzheimer's disease, i.e. amyloid-β plaques and neurofibrillary tangles comprised of hyperphosphorylated tau. Depending on the type and location of trauma,

Om alla människor hade möjlighet att välja medborgarskap, som man väljer bostad eller annan konsumtion, skulle vi implicit observera deras preferensergenom dessa beslut. Medborgarskap kan betraktas som privat men ej överlåtbar egendom. Om medborgarskapet blev överlåtbart och vi kunde handla meddem och hade en etablerad handelsplats – likt en aktiebörs – skulle vi kunna observera marknadspriser på

Generalist parasites experience selective pressures from the various host species they infect. However, it is unclear if parasite transmission among host species precludes the establishment of host-specific adaptations and population genetic structure. We assessed the population genetic structure of the vector-transmitted avian haemosporidian parasite Haemoproteus majoris (lineage WW2; n = 34 infe

Plast präglar i stort sett allting i det moderna livet och bidrar till miljöförstöring och avfallsgenerering på global nivå. Denna avhandling undersöker hur plastavfall blev djupt inbäddat i Sveriges kulturella, politiska och ekonomiska strukturer. Med hjälp av ett ramverk baserat på kulturell politisk ekonomi (CPE) används tre perspektiv - hegemoni, inlåsningseffekter och praktiker - för att analPlastic disposability is a pervasive feature of modern life, contributing to environmental degradation and waste generation on a global scale. This dissertation investigates how plastic disposability became deeply embedded within Sweden's cultural, political, and economic structures. Using a Cultural Political Economy (CPE) framework, it applies three lenses – hegemony, lock-in, and practice – to

Purpose: Whey protein (WP) consumption prior to a meal curbs appetite and reduces postprandial glucose (PPG) through stimulating endogenous GLP-1 secretion and insulin. Methods: We assessed the metabolic effects of a concentrated WP, using a new micelle-technology (WPM), in people with type 2 diabetes (T2D) and overweight or obesity (NCT04639726). In a randomized-crossover design, participants per

Epilepsy is a chronic neurological disorder marked by recurrent seizures, significantly impacting individuals worldwide. Current treatments are often ineffective for a third of patients and can cause severe side effects, necessitating new therapeutic approaches. Glial cells, particularly astrocytes, microglia, and oligodendrocytes, are emerging as crucial targets in epilepsy management. Astrocytes

Aims: An explainable advanced electrocardiography (A-ECG) Heart Age gap is the difference between A-ECG Heart Age and chronological age. This gap is an estimate of accelerated cardiovascular aging expressed in years of healthy human aging, and can intuitively communicate cardiovascular risk to the general population. However, existing A-ECG Heart Age requires sinus rhythm. We aim to develop and pr

Background Water retention, ultrafiltration insufficiency, and metabolic complications due to abnormally high glucose concentrations are still common problems in patients treated with peritoneal dialysis. Phloretin, a nonselective inhibitor of facilitative glucose transporter channels (GLUT), has shown to improve water transport and lower glucose absorption in experimental peritoneal dialysis. How

Aim: To explore the meaning of adaptation after visceral transplantation in terms of patient experiences, symptoms, self-efficacy, transplant-specific and mental well-being. Design: A convergent parallel mixed-methods study, consisting of interviews and generic as well as transplant-specific questionnaires. Results were integrated using meta-inference. Methods: The study comprises a population of

Quantum technologies and experiments often require preparing systems in low-temperature states. Here we investigate cooling schemes using feedback protocols modeled with a quantum Fokker-Planck master equation (QFPME) recently derived by Annby-Andersson et al. [Phys. Rev. Lett. 129, 050401 (2022)0031-900710.1103/PhysRevLett.129.050401]. This equation describes systems under continuous weak measure