Amyloid peptide (AP) self-assembly is a hierarchical process. However, the mechanistic rule of guiding peptides to organize well-ordered nanostructure in a clear and precise manner remains poorly understood. Herein we explored the molecular insight of AP motif aggregates underlying hierarchical process with helical fibrillar structure by atomic force microscope, cryo-electron microscopy (cryo-EM),

Embedded-cluster models of crystalline solids are important to allow accurate wave function methods to be applicable to solids. The ab-initio model potential method, in which the crystal is divided into three different fragments, one quantum fragment, one ab-initio model potential fragment and one point-charge fragment, has historically been shown to be a viable tool for describing the electronic

This review presents state-of-the-art knowledge and identifies knowledge gaps for future research in the area of exercise-associated modifications of infection susceptibility. Regular moderate-intensity exercise is believed to have beneficial effects on immune health through lowering inflammation intensity and reducing susceptibility to respiratory infections. However, strenuous exercise, as perfo

Introduction: Half a century since the creation of the International Association of Bryologists, we carried out a review to identify outstanding challenges and future perspectives in bryology. Specifically, we have identified 50 fundamental questions that are critical in advancing the discipline. Methods: We have adapted a deep-rooted methodology of horizon scanning to identify key research foci.

The upwelling area off Peru is characterized by exceptionally high rates of primary productivity, mainly dominated by diatoms, which require dissolved silicic acid (dSi) to construct their frustules. The silicon isotope compositions of dissolved silicic acid (δ30SidSi) and biogenic silica (δ30SibSi) in the ocean carry information about dSi utilization, dissolution, and water mass mixing. Diatoms a

Public transportation (PT) is an essential system for cities to achieve sustainability. However, determination of proper locations for PT stations and finding suitable routes are critical decisions. This paper aims to propose a novel method to determine BRT stations and routes in the cities, using Fuzzy Inference System (FIS) and Binary Integer Programming (BIP). In the proposed method, first, a s

The understanding of patients under the age of 60 with hip fractures have been influenced by preconceptions that fractures are due to high-energy trauma and the risk of osteoporosis is low. The patients’ perspectives have seldomly been presented and the surgical results were insufficiently described. This thesis project was developed in response to the relative lack of research on this patient gro

Artificial moral agents must not only be able to make competent ethical decisions, but they must do so effectively. This paper explores how ethical theory and algorithmic design impact computational efficiency by assessing the time cost of ethical algorithms. We create a model of an ethical environmentand conduct experiments on three different ethical algorithms in order to compare computational b

Plastic waste has come to the forefront of academic and political debates as a global problem that demands an urgent solution. Promoted by policymakers, academia, and corporations alike, the circular economy model presents a viable path to reach more sustainable levels of development. Emerging and disruptive technologies can catalyse the transition to a circular economy, but their application to t

The notion of the "adjacent possible" has been advanced to theorize the generation of novelty across many different research domains. This study is an attempt to examine in what way the notion can be made empirically useful for innovation studies. A theoretical framework is construed based on the notion of innovation a search process of recombining knowledge to discover the "adjacent possible". Th

The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to id

Background: Prosthetic valve endocarditis (PVE) is a feared complication after heart valve surgery. Studies on differences in bacteriology in various types of PVE are limited. Objectives: This study aimed to investigate the microbiology of PVE depending on the type of prosthetic valve and timing of diagnosis. Methods: A retrospective study based on the Swedish Registry on Infective Endocarditis fo

Plasma-wakefield acceleration (PWFA) relies on the interaction between intense particle bunches and plasma for reaching higher accelerating gradients than what is possible with conventional radio-frequency technology. Using ultra-relativistic beam drivers allows for long acceleration lengths and have potential applications such as energy booster stages for synchrotron light sources or linear colli

There is limited knowledge about the associations between intakes of different foods and inconsistency in the literature of the relation between the quality of food intake and bodyweight in adolescents. The aim of this study is to explore how healthy self-reported food intakes are associated with each other and with overweight/obesity in adolescents. This is a cross-sectional study of seven cohort

Code review is a common practice in software development andnumerous studies have described different aspects of the process;its characteristics, the expectations on that process, issues aroundreviewer allocation, and more. However, one aspect that has notbeen studied to a large extent is the experience of the developersin the code review process. This is unfortunate given the signifi-cant amount

Introduction: People with haemophilia (PwH) may experience symptoms of haemophilia-related pain, depression or anxiety, which can negatively impact health-related quality of life. Aim: To obtain the perspective of PwH and treaters from Sweden, Finland and Denmark on the management of haemophilia-related pain, depression and anxiety using cross-sectional survey data from the MIND study (NCT03276130