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In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of acid-sensitive monoclonal antibodies, prone to aggregate at low pH, on pilot scale. A high cell density perfusion culture, stably maintained at 100 × 106 cells/ml, was integrated with the downstream process, consisting of a capture step with the recently developed Prote
In Sweden and other countries it is not an uncommon practice that freight trains depart more or less on-demand instead of strictly following a pre-planned timetable. However, the systematic effects of freight trains departing late or (in particular) early has long been a contested issue. Although some microscopic simulation tools currently have the capability to evaluate the effect of freight trai
Very little is known about what family life looked like for settlers in colonial South Africa during the 18th or 19th century, nor how events over these centuries might have affected demographic change. The primary reason for this lacuna is a shortage of adequate data. Historians and genealogists have, over the last century, worked to combine the rich administrative records that are available in t
In the informal settlements of warm humid climates, where the majority of urbanites spend most of their time outdoors, a conducive thermal environment is crucial for their social and economic well-being. The overall aim of this thesis is to increase knowledge and understanding of outdoor thermal comfort in informal settlements in the warm and humid climate of Dar es Salaam, Tanzania. Urbanites’ th
OBJECTIVES: Coronary artery calcium score (CACS) is a marker of subclinical atherosclerosis. However, there is little data related to the association between arterial stiffness and CACS in the general population. The aim of this study was to explore the association between carotid femoral-pulse wave velocity (c-f PWV), a widely accepted marker of arterial stiffness, and CACS.METHODS: Participants
This chapter provides a survey of the existing quantitative research on antisemitism and social media. Through doing so, it argues that the sheer quantity of antisemitism on social media is much less than commonly perceived. In addition, the chapter argues that quantitative research often neglects counter-narratives calling out antisemitism, which are an important counterpoint to include in antise
Whilst network coordination games and network anti-coordination games have received a considerable amount of attention in the literature, network games with coexisting coordinating and anti-coordinating players are known to exhibit more complex behaviors. In fact, depending on the network structure, such games may even fail to have pure-strategy Nash equilibria. An example is represented by the we
We study extensions of the classical SIR model of epidemic spread. First, we consider a single population modified SIR epidemics model in which the contact rate is allowed to be an arbitrary function of the fraction of susceptible and infected individuals. This allows one to model either the reaction of individuals to the information about the spread of the disease or the result of government rest
The Bonacich centrality is a well-known measure of the relative importance of nodes in a network. This notion is, for example, at the core of Google’s Page Rank algorithm. In this paper we study a network formation game where each player corresponds to a node in the network to be formed. The action of a player consists in the assignment of m out-links and his utility is his own Bonacich centrality
