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PRECLINICAL DRUG DISCOVERY AND DEVELOPMENT FOR A NOVEL ALZHEIMER’S DISEASE DRUG : - A stroy of an orphan -

Alzheimer’s disease is a severe neurodegenerative disease, affecting the life of millions of patients and those who stand close to them. There is an urgent need for new effective medical treatments targeting this disease, as up to now, there is none. GPR3, a highly constitutively active orphan G protein coupled receptor, was found to interact with several different molecules that are known to play

The Carbon Impact of Component Production in China: Investigating the Impact of Carbon Border Adjustment Policies for a Global Manufacturing Company

Title: The Carbon Impact of Component Production in China: Investigating the Impact of Carbon Border Adjustment Policies for a Global Manufacturing Company Authors: Fabian Bergman & Spiros Pavlidis Supervisor: Eva Berg, Lecturer at Engineering Logistics, Faculty of Engineering (LTH) at Lund University Examiner: Louise Bildsten, Associate Lecturer at Engineering Logistics, Faculty of Enginee

INCREASED LEVELS OF ADVANCED GLYCATION END PRODUCTS ARE ASSOCIATED WITH HIGHER AORTIC STIFFNESS IN YOUNGER INDIVIDUALS OF THE GENERAL POPULATION

Objective: Advanced Glycation End products (AGEs) is an established risk marker in diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in older individuals. The relationship between aortic stiffness and AGEs has not been thoroughly examined in the younger population. We aimed to evaluate the association between AGEs and aortic sti

Identifying the Barriers to Pre-owned Fashion: A Consumer Perspective

Thesis Purpose: This study aims to enhance the understanding of factors that discourage consumers from buying pre-owned fashion in a multichannel retail setting. Methodology: Rooted in a qualitative and exploratory method, this study is further guided by an abductive approach. By embracing the essence of the social constructivist epistemology and a relativistic ontological standpoint, it delves i

Innovation Investments During The COVID-19 Pandemic

The authors of this paper identified a gap in the debate revolving around innovation during a crisis and recognized the importance of exploring whether being highly innovative is universally desirable across all sectors during times of crisis. While previous research has emphasized the positive impact of innovation on performance, it is essential to investigate the negative impact of innovation an

Stigma och självbild hos äldre arbetslösa – en studie om personer över 55 år och deras situation i långtidsarbetslöshet

Denna kandidatuppsats syfte var att ta reda på hur personer över 55 år upplever sin situation som långtidsarbetslöshet i Sverige. Hur man upplever normer och fördomar och på vilket sätt det påverkar arbetslösas självbild. För att kunna besvara studiens frågeställningar har intervjuer gjorts med tre deltagare för att få en djupare inblick över deras situation och deras egna upplevelser av att vara

Effects of split diesel injection strategies on combustion, knocking, cyclic variations and emissions of a natural gas-diesel dual fuel medium speed engine

Accelerated by the harms and depletion risk of fossil fuels, transition to low-carbon or renewable fuels have become an urgent need for combustion engines to decarbonize transport sectors. Natural gas-diesel dual-fuel combustion is a promising method to achieve these goals by allowing the usage of natural gas in diesel engines. However, this concept has drawbacks of low combustion efficiency, high

The Path to the Soft Life: Exploring the Blesser Phenomenon in South Africa

South Africa has one of the highest incidences of HIV in the world and young women are disproportionately affected. Scholars have pointed to the practice of Transactional Sexual Relationships (TSR) as a driving force behind HIV incidences among young women. However, research devoted towards understanding TSR and why women engage in these relationships remains debated. In 2016, the Blesser-phenomen

Investigation of Analog Calibration Systems for Spurious Tone Suppression in Frequency Triplers

The market for Wi-Fi receiver designs for latest Wi-Fi standards, that cover RF bands in the 2.4 GHz, 5 GHz and 6 GHz spectrum, require increasingly stringent power consumption limitations as more of the market is driven towards battery-powered devices. In order to meet those needs, it is crucial to explore different ways of reducing power consumption in various receiver blocks. One such power con

Modification of serum fatty acids in preterm infants by parenteral lipids and enteral docosahexaenoic acid/arachidonic acid : A secondary analysis of the Mega Donna Mega trial

Background & aim: Preterm infants risk deficits of long-chain polyunsaturated fatty acids (LCPUFAs) that may contribute to morbidities and hamper neurodevelopment. We aimed to determine longitudinal serum fatty acid profiles in preterm infants and how the profiles are affected by enteral and parenteral lipid sources. Methods: Cohort study analyzing fatty acid data from the Mega Donna Mega stud

Sensitive methods for assessment of lung health in welders and controls

Background: Welders are exposed to gas and particle emissions that can cause severe lung disease, such as chronic obstructive pulmonary disease (COPD), a leading cause of mortality and morbidity worldwide. It is difficult to detect COPD early and therefore mitigating measures may be delayed. The aim of this study was to investigate lung health in welders and evaluate new sensitive methods with pot

Bridging the Divide: Employees’ Stigma Management in the Dutch Nuclear Industry

Purpose: The purpose of this research is to investigate the perception and management of stigma in the Dutch nuclear industry. To investigate this, the following research questions have been developed: How do employees of the Dutch nuclear industry perceive the stigmatization of the industry and its effects on the industry? How do employees manage the stigma in order to bridge the divide between

The Chameleon Effect: Rethinking Innovation as an Adaptive Resemblance

The purpose of this study is to extend our knowledge of the elusive concept of innovation by investigating meanings and experiences of it among members in a small med-tech organization. This involves examining how individuals interpret and make sense of innovation and, if or how, they relate to their own organization as an innovative one. A single organization has been studied through an abductive

Meaningful work: Leadership Influence and Individual Discovery

Purpose: The main purpose of this research is to get a better understanding of how leadership influences individual perceptions of meaningful work. The interplay between leadership and individuals in meaningful work is also investigated. Methodology: This is a qualitative study following the abductive approach and interpretivism research philosophy. Data is collected through 12 semi-structured in

“Clean Girl” : den nya utgångspunkten för kvinnliga ideal? - en kvalitativ studie av hur kvinnliga ideal konstrueras på TikTok, mediafenomenet “Clean Girl”, och hur detta fenomen påverkar unga kvinnliga användare

Denna studies syfte är att undersöka hur användare av plattformen TikTok uppfattar att kvinnliga ideal konstrueras på plattformen med ett fokus på det aktuella mediafenomet “Clean Girl”. Studien ämnar även att urskilja fenomenets eventuella påverkan på dess användare på både en samhällelig och individuell nivå. Vi har valt att utgå från en kvalitativ metod där vi med hjälp av fokusgrupper har inte

Bildning och assimilering : En diskursanalys av sverigedemokratisk bibliotekspolitik

The purpose of this study is to create an understanding of how the increased influence of the radical right party the Sweden democrats in Swedish politics may change how the democratic role of the public libraries is understood. The research questions asked are which discourses concerning cultural politics and library politics that can be discerned in cultural policy statements from the Sweden dem

“One can imagine one’s making a conscious choice” : AI and algorithmic awareness among Swedish public librarians

I denna uppsats ger jag en inblick i hur bibliotekarier på folkbibliotek uppfattar, förstår och interagerar med algoritmer och AI i relation till sitt yrke. Mitt främsta fokus ligger på hur bibliotekariernas uppfattningar av algoritmer och AI i slutändan formar deras handlingar. För att uppnå detta syfte tar jag min utgångspunkt i deras personliga syn på algoritmer och AI. Materialet för denna uppIn this thesis I provide insight into how librarians at public libraries perceive, understand, and interact with algorithms and AI in relation to their profession. My main focus lies in how librarians’ perceptions of algorithms and AI ultimately shape their actions. To achieve this aim I take my starting point from their privately held views of algorithms and AI. The material for the thesis is gat

Vem är en auktoritet? : Hur katalogisatörer inom LIBRIS-samarbetet söker, värderar och använder information

This master’s thesis is about cataloguing and information practices. In Sweden, most cataloguing is done in LIBRIS, a national database containing the collections of most public and academic libraries in the country. The people who catalogue books and other types of media in this database work at libraries that span the entire nation. It is a national collective engaged in the joint enterprise of