Non-therapeutic research on children raises ethical concerns. Such research is not only conducted on individuals who are incapable of providing informed consent. It also typically involves some degree of risk or discomfort, without prospects of medically benefiting the participating children. Therefore, these children seem to be instrumentalized. Some ethicists, however, have tried to sidestep thi

A prototype to a water-cooled applicator to be used in transurethral laser-induced thermotherapy of benign prostatic hyperplasia was developed. The flexible applicator was made of Teflon(TM) tubes except for the distal outer part which was made of glass, providing a transparent medium for laser radiation and enabling efficient cooling of the surrounding tissue. For heating, laser light from a Nd:Y

Popular Abstract in Swedish I Ärlighetseffekten. Den litterära självbiografin sedd genom pressen. Fallet La Force des choses av Simone de Beauvoir undersöks den litterära självbiografin som genre sedd genom receptionen i pressen av den tredje delen av Simone de Beauvoirs självbiografi La Force des choses vid utgivningen i Frankrike 1963. Studien innehåller tre huvuddelar som tar upp kommentarerna In light of autobiographical theory, this study deals with the critics' reception of Simone de Beauvoir's La Force des choses when the book was first published in 1963 in France. The three main parts examine the critical comments on the genre, the final controversial words expressing the author's disappointment, and the evaluation of her style. For the latter, Morten Nøjgaard's theory of literary

Turbulent partially premixed flames are found in common combustion applications, such as the lifted jet flames in diesel engines. There is less theory surrounding the structure and propagation of turbulent partially premixed flames than for classical premixed flames and diffusion flames, especially in regards to modelling. This thesis presents direct numerical simulations (DNS) and analysis of the

Objective. Patients with inflammatory bowel disease (IBD) often have low iron stores or anaemia. There is controversy about whether iron should be supplemented orally or intravenously (i.v.). The purpose of this study was to investigate whether treatment with intravenous iron is superior to treatment with oral iron. The primary end-points were response and remaining anaemia at the end of treatment

We introduce canonical bases for subalgebras of quotients of the commutative and non-commutative polynomial ring. The usual theory for Gröbner bases and its counterpart for subalgebras of polynomial rings, also called SAGBI bases, are combined to obtain a tool for computation in subalgebras of factor algebras.

Binding of urokinase plasminogen activator (uPA) to its cellular receptor, uPAR, potentiates plasminogen activation and localizes it to the cell surface. Focal plasminogen activation is involved in both normal and pathological tissue remodeling processes including cancer invasion. The interaction between uPA and uPAR therefore represents a potential target for anti-invasive cancer therapy. Inhibit

Modelling is a wide concept. This paper describes various meanings of modelling in relation to mechanical properties of wood and wood-based materials. Three examples of modelling by means of the finite element method, presented in recent years in PhD theses, are used as reference points. They relate to modelling of the micro-structure of wood and its mechanical properties, modelling of drying-indu

Apolipoprotein M (apoM) is predominantly associated with HDL. In this study, it was investigated whether apoM's uncleaved signal peptide is necessary for the protein's ability to associate with lipoproteins. ApoM with a cleavable signal peptide, Q22A, was expressed, together with wild-type apoM, in HEK293 cells. On size-exclusion chromatography, the elution profile of wild-type apoM was similar to

Pancreatic cancer is a devastating disease with poor prognosis. It is characterized by a pronounced stromal reaction, which resists chemotherapeutics and effective tumor treatment. Pancreatic stellate cells (PSCs) are mainly responsible for this stromal reaction. Moreover, the cancer and stromal interaction seems to promote tumor proliferation. In this study, L49H37, a newly synthesized curcumin a