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A palynological study from Sweden reveals stable terrestrial environments during Late Silurian extreme marine conditions

A palynological study of the upper Silurian Oved-Ramsasa Group in Skane, Sweden yields a well preserved spore assemblage with low relative abundances of marine microfossils. In total, 26 spore taxa represented by 15 genera were identified. The spore assemblage is dominated by long-ranging cryptospore taxa, and the trilete spore Ambitisporites avitus-dilutus. However, key-species identified include

Fruit and vegetable intake and cause-specific mortality in the EPIC study

Consumption of fruits and vegetables is associated with a lower overall mortality. The aim of this study was to identify causes of death through which this association is established. More than 450,000 participants from the European Prospective Investigation into Cancer and Nutrition study were included, of which 25,682 were reported deceased after 13 years of follow-up. Information on lifestyle,

Antimicrobial effects of helix D-derived peptides of human antithrombin III.

Antithrombin III (ATIII) is a key antiproteinase involved in blood coagulation. Previous investigations have shown that ATIII is degraded by Staphylococcus aureus V8 protease, leading to release of heparin binding fragments derived from its D helix. As heparin binding and antimicrobial activity of peptides frequently overlap, we here set out to explore possible antibacterial effects of intact and

Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus

Introduction: Polymorphonuclear leukocytes (PMN) are main effector cells in the acute immune response. While the specific role of PMN in systemic lupus erythematosus (SLE) and autoimmunity is still unclear, their importance in chronic inflammation is gaining more attention. Here we investigate aspects of function, bone marrow release and activation of PMN in patients with SLE. Methods: The followi

Anti-browsing effects of birch bark extract on fallow deer

A major problem within forest industry is unwanted browsing on seedlings from mammalian herbivores. The aim of this study was to evaluate the effects of birch bark extracts as repellents towards fallow deer. Birch bark was extracted in a conventional way with ethanol as solvent at ambient temperature and with a new method, liquid CO2 extraction. An analysis of the ethanol-extracted birch bark show

The role of AIB1 and PAX2 in primary breast cancer: validation of AIB1 as a negative prognostic factor.

BackgroundThe steroid-receptor coactivator amplified in breast cancer one (AIB1) is implicated to be a prognostic factor, although the results are not unanimous. Recently its effect was suggested to be modified by paired box 2 gene product (PAX2).Patients and methodsUsing immunohistochemistry (IHC) AIB1 and PAX2 were investigated in two cohorts of early breast cancer, including systemically untrea

Biotic dynamics and carbonate microfacies of the conspicuous Darriwilian (Middle Ordovician) 'Taljsten' interval, south-central Sweden

Enclosed in the Darriwilian (Middle Ordovician) part of the reddish 'orthoceratite limestone' of Baltoscandia is a conspicuous c. 1.5 m thick unit colloquially known as the 'Taljsten' interval. It has a wide geographical distribution in the Baltoscandian paleocontinent but is particularly well exposed in south-central Sweden. The unit is characterized by its deviant gray color and beds with a mass

Bit-Serial CORDIC: Architecture and Implementation Improvements

Abstract in UndeterminedThis paper presents a new and improved bit-serial CORDIC architecture. A detailed description of the bit-serial implementation and its Control Unit is presented. It is shown that the improvement is due to a reduction of registers in the implementation and is made possible by ensuring that the angular path is calculated prior to the corresponding vector paths. In addition, t

A trade-off between perceived predation risk and energy conservation revealed by an immune challenge experiment

Energy is typically a limiting factor for animals during boreal zone winters, when low temperatures increase the cost of thermoregulation at the same times as short day-lengths and snow cover constrain foraging opportunities. Under these circumstances animals use a suite of behavioural and physiological adaptations to avoid overnight starvation. However, it is poorly understood how such strategies

Pan-vertebrate comparative genomics unmasks retrovirus macroevolution.

Although extensive research has demonstrated host-retrovirus microevolutionary dynamics, it has been difficult to gain a deeper understanding of the macroevolutionary patterns of host-retrovirus interactions. Here we use recent technological advances to infer broad patterns in retroviral diversity, evolution, and host-virus relationships by using a large-scale phylogenomic approach using endogenou

Toward Next Generation Plasma Profiling via Heat-induced Epitope Retrieval and Array-based Assays

There is a need for high throughput methods for screening patient samples in the quest for potential biomarkers for diagnostics and patient care. Here, we used a combination of undirected target selection, antibody suspension bead arrays, and heat-induced epitope retrieval to allow for protein profiling of human plasma in a novel and systematic manner. Several antibodies were found to reveal alter

Mid-term follow-up of patients with permanent sequel due to spinal cord ischemia after advanced endovascular therapy for extensive aortic disease.

Study design:Observational study.Objectives:Thoraco-abdominal endovascular aortic aneurysm repair (TAEVAR) can be used to treat patients with extensive and complex aortic disease, however, at the risk of spinal cord ischemia (SCI). The aim of this follow-up study was to evaluate the life satisfaction in patients with SCI after TAEVAR.Setting:Among 83 patients undergoing TAEVAR between 2009 and 201

Effectiveness of the systematic engineering design methodology

This paper reviews a set of published industrial applications and research studies in order to assess the effectiveness of the systematic engineering design methodology. Effectiveness, which can be considered as the degree to which the final design solution fulfils the design requirements, is one of the critical features of a design methodology. It cannot be concluded upon the reviewed publication

Effects of ketogenic diet on vascular function.

Ketogenic diet is a well-established treatment in children with difficult to treat epilepsy. Very little is known about the long-term effects on vascular atherogenic and biochemical processes of this high-fat and low carbohydrate and protein diet.

Characterisation and evaluation of a novel feedstock, Manihot glaziovii, Muell. Arg, for production of bioenergy carriers: Bioethanol and biogas.

The objective of this study was to characterise and evaluate a wild inedible cassava species, Manihot glaziovii as feedstock for bioenergy production. Tubers obtained from 3 different areas in Tanzania were characterised and evaluated for bioethanol and biogas production. These bioenergy carriers were produced both separately and sequentially and their energy values evaluated based on these two ap

Composition- and Size-Controlled Cyclic Self-Assembly by Solvent- and C60-Responsive Self-Sorting.

Synthesis, solvent-, and guest-controlled self-assembly, and self-sorting of new hydrogen-bonded chiral cavity receptors are reported. The design of the cavity is based on the cyclic self-aggregation of monomers containing the 4H-bonding ureidopyrimidinone motif fused with the bicylo[3.3.1]nonane framework. Selective formation of kinetically inert cyclic tetramers is observed in chloroform, while

Natural disasters, climate change and non-refoulement: What scope for resisting expulsion under Articles 3 and 8 of the European Convention on Human Rights?

Climate change is already contributing to the displacement of millions of people worldwide as extreme weather events become increasingly frequent and intense. Proposals for responding to the phenomenon of climate change-related displacement overwhelmingly rely on the state to act, with limited discussion of the potential to determine and develop the scope of protection through strategic litigation

Acoustic actuated fluorescence activated sorting of microparticles.

In this paper, we present a fluorescence activated sorter realized in a continuous flow microfluidic chip. Sorting is achieved by deflecting a focused particle stream with short acoustic bursts (2.5 ms), in a fluorescence activated configuration. The system utilizes two-dimensional acoustic pre-focusing, using a single actuation frequency, to position all particles in the same fluid velocity regim

Bringing the individual back to small-area variation studies: A multilevel analysis of all-cause mortality in Andalusia, Spain.

We performed a multilevel analysis (including individuals, households, census tracts, municipalities and provinces) on a 10% sample (N=230,978) from the Longitudinal Database of the Andalusian Population (LDAP). We aimed to investigate place effects on 8-year individual mortality risk. Moreover, besides calculating association (yielding odds ratios, ORs) between area socio-economic circumstances a