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A straightforward synthesis of anti-3-alkenyl-2-amido-3-hydroxy esters from the corresponding racemic α-amino-β-keto esters by using a ATH/DKR protocol has been developed. This method gives moderate to excellent yields with high chemo-, diastereo- and enantioselectivities for a broad range of substrates. In order to highlight the versatility of the methodology it was applied in an efficient asymme

Objective: Routine antibiotic treatment of acute uncomplicated diverticulitis (AUD) has been shown ineffective. In this study, the adherence to a new treatment protocol for uncomplicated diverticulitis was evaluated and the incidence of complications in patients treated with and without antibiotics was investigated. Materials and methods: A retrospective study of in-patients diagnosed with AUD at

Anxiety and stress-related disorders are highly prevalent and impede participation in life activities. Occupational therapists work extensively with people diagnosed with these disorders but the effectiveness of their interventions is unclear. A systematic search strategy identified 19 papers describing 13 studies. Studies varied in methodology, intervention type, and theory base. The results show

This paper aims at developing a benchmark simulation model to evaluate control strategies for the urban catchment and sewer network. Various modules describing wastewater generation in the catchment, its subsequent transport and storage in the sewer system are presented. Global/local overflow based evaluation criteria describing the cumulative and acute effects are presented. Simulation results sh

We study a capacitated network design problem in a geometric setting. The input consists of an integral edge capacity k and two sets of points on the Euclidean plane, sources, and sinks, with an integral demand for each point. The demand of each source specifies the amount of flow that has to be shipped from the source, and the demand of each sink specifies the amount of flow that has to be shippe

With the increasing focus on reducing emissions and making fuel efficient vehicles within the automotive industry over the past few years, new methods are constantly being investigated to improve the efficiency of the powertrain. One such method is recovering waste heat from the exhaust gases as well as the coolant using a thermodynamic cycle such as a Rankine cycle. However, most studies looking With the increasing focus on reducing emissions and making fuel efficient vehicles within the automotive industry over the past few years, new methods are constantly being investigated to improve the efficiency of the powertrain. One such method is recovering waste heat from the exhaust gases as well as the coolant using a thermodynamic cycle such as a Rankine cycle. However, most studies looking

Objectives: Restricted capacity for viral load (VL) testing is a major obstacle for antiretroviral therapy (ART) programmes in high-burden regions. Algorithms for targeted VL testing could help allocate laboratory resources rationally. We validated the performance of the Viral Load Testing Criteria (VLTC), an algorithm with satisfactory performance in derivation (sensitivity 91%, specificity 43%).

Pulmonary artery grafts are needed as cardiovascular bioprosthetics. For successful tissue recellularization after transplantation, lipids have to be removed from the donor artery. Developing a selective process to remove lipids without damaging the extracellular matrix greatly depends on knowing the amount and type of lipid compounds in the specific tissue. Here we present an efficient methodolog

The pharynx is critical for correct swallowing, facilitating the transport of both air and food transport in a highly coordinated manner, and aberrant co-ordination causes swallowing disorders (dysphagia). In this work, an in vitro model of swallowing was designed to investigate the role of rheology in swallowing and for use as a pre-clinical tool for simulation of different routes to dysphagia. T

In this work a simplified approach to array optimization for the DC resistivity and induced polarization method have been created and tested. The optimization method uses the centre of the sensitivity function for the individual electrode configurations, called the mass centre, which is spread over the area of investigation, wherefrom the name Spread of Mass Centre (SMC). This array has been teste

Physiological arousal is considered a key factor of gambling behavior. Hence, to understand gambling behavior it is important to study the arousal responses during gambling. Moreover, crucial mechanisms of action could be uncovered by detailing the situations that produce an arousal response. A gamble, or bet, can be partitioned into three distinct phases: (a) decision phase, during which the info

The environment where an embryo develops can be influenced by components of maternal origin, which can shape offspring phenotypes and therefore maternal fitness. In birds that produce more than one egg per clutch, females differ in the concentration of components they allocate into the yolk along the laying sequence. However, identification of processes that shape female yolk allocation and thus o

Increased organic loading to sediments from eutrophication often results in hypoxia, reduced nitrification and increased production of hydrogen sulfide, altering the balance between nitrogen removal and retention. We examined the effect of short-term exposure to various oxygen and sulfide concentrations on sediment nitrification, denitrification and DNRA from a chronically hypoxic basin in Roskild

Climate change will bring about a consistent increase in temperatures. Annual precipitation rates are also expected to increase in boreal countries, but the seasonal distribution will be uneven, and several areas in the boreal zone will experience wetter winters and drier summers. This study uses the dynamic forest ecosystem model ForSAFE to estimate the combined effect of changes in temperature a

Geophysical methods provide important information for mapping the subsurface. In semiarid areas, a detailed knowledge of the aquifers geometry can assist to a better management of groundwater. In the Valle Alto (Bolivia), which is a semiarid region, there is gap in the knowledge about the aquifer system geometry and hydrogeological processes. Local reports indicated problems in some wells such as

General hospital care and treatment of mentally ill patients in a Swedish town was studied in records for 503 patients, 1896–1905. Restraint was extremely rare; 65% left the hospital as healthy or improved. Non-psychotic and alcoholic patients spent fewer days in hospital than patients with psychosis or dementia. There was no evidence of a social status bias. For 36% of the patients a certificate

This paper investigates the factors that influence Swedish welfare workers’ attitudes towards migrants and how these attitudes are associated with their encounters with migrant users. Due to increased migration over the last decade, Sweden is now considered an immigrant nation. Migrants with the right to reside in Sweden are included within the larger welfare system. This paper argues that preconc

Objective: The goal of this study was to optimize robust PID control for propofol anesthesia in children aged 5-10 years to improve performance, particularly to decrease the time of induction of anesthesia while maintaining robustness.Methods: We analyzed results of a previous study conducted by our group to identify opportunities for system improvement. Allometric scaling was introduced to reduce

The present paper assesses the usage of relational ontologies in the realm of macromarketing made available by consumer culture theorists. Our paper advances this movement by exploring the potential of relational ontologies to propel a more thorough methodological discussion and operationalization of relationality in macromarketing. To fulfill this task, the paper first identifies and discusses fo