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INTRODUCTION: Variability in relationship of tau-based neurofibrillary tangles (T) and neurodegeneration (N) in Alzheimer's disease (AD) arises from non-specific nature of N, modulated by non-AD co-pathologies, age-related changes, and resilience factors. METHODS: We used regional T-N residual patterns to partition 184 patients within the Alzheimer's continuum into data-driven groups. These were c

High-energy synchrotron X-ray small-angle scattering (SAXS) is used to study the precipitate development during hot rolling and cooling of a commercial Ti–Nb micro-alloyed, high-strength, low-alloy (HSLA) steel. To study precipitation during hot rolling conditions, Gleeble and dilatometer trials are made. Samples are then studied at room temperature using SAXS in conjunction with transmission elec

Background: Lead exposure is associated with cardiovascular disease. Atherosclerosis has been hypothesized to be one of the underlying mechanisms behind this association. Aim: To investigate whether lead exposure is associated with an increased risk of atherosclerosis in the carotid arteries in a large Swedish population-based cohort. Methods: We performed a cross-sectional study using data from t

The organization and coordination of fish schools provide a valuable model to investigate the genetic architecture of affiliative behaviours and dissect the mechanisms underlying social behaviours and personalities. Here we used replicate guppy selection lines that vary in schooling propensity and combine quantitative genetics with genomic and transcriptomic analyses to investigate the genetic bas

Background: Androgen deprivation therapy is the cornerstone of treatment for patients with advanced prostate cancer. Meta-analysis of small, oncology-focused trials suggest gonadotropin-releasing hormone (GnRH) antagonists may be associated with fewer adverse cardiovascular outcomes compared with GnRH agonists. Objectives: This study sought to determine whether GnRH antagonists were associated wit

Background: Ampullary lesions are rare and can be locally treated either with endoscopic papillectomy or transduodenal surgical ampullectomy. Management of local recurrence after a first-line treatment has been poorly studied. Methods: Patients with a local recurrence of an ampullary lesion initially treated with endoscopic papillectomy or transduodenal surgical ampullectomy were retrospectively i

Cardiometabolic disease is a major threat to global health. Precision medicine has great potential to help to reduce the burden of this common and complex disease cluster, and to enhance contemporary evidence-based medicine. Its key pillars are diagnostics; prediction (of the primary disease); prevention (of the primary disease); prognosis (prediction of complications of the primary disease); trea

This paper reports on CFD modeling of the fuel/air mixing characteristics of liquid ammonia under direct injection engine-relevant conditions. Several questions are addressed including, whether the widely used Lagrange particle tracking (LPT) spray models developed for traditional fossil fuels are suitable for ammonia spray, whether certain improvement of the current models should be introduced, a

Background: Season of birth has been associated with age at menarche. Maternal vitamin D levels in pregnancy may explain this effect. We investigated whether the season of first trimester or maternal 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with pubertal timing in children. Methods: We conducted a follow-up study of 15 819 children born in 2000-03 from the Puberty Cohort, nested in t

Background:Non-motor symptoms (NMS) reduce quality of life in Parkinson’s disease (PD) patients, who experience three times more NMS than individuals without PD. While there are international and national NMS treatment guidelines, their implication in clinical practice remains unclear.Objective:This study aimed to investigate the adherence to pharmacological NMS treatment guidelines in patients wi

Fruit juices are a key global beverage with an increasing market and membrane processes are key processes in fruit juice processing. The most established membrane processes are the pressure-driven processes: microfiltration and ultrafiltration for the clarification the juices plus nanofiltration and reverse osmosis the concentration/pre-concentration of the juices. Additionally, the potential of t

We present the first systematic comparison of the charged-particle pseudorapidity densities for three widely different collision systems, pp, p–Pb, and Pb–Pb, at the top energy of the Large Hadron Collider (sNN=5.02TeV) measured over a wide pseudorapidity range (−3.5

The study of the azimuthal anisotropy of inclusive muons produced in p–Pb collisions at sNN=8.16 TeV, using the ALICE detector at the LHC is reported. The measurement of the second-order Fourier coefficient of the particle azimuthal distribution, v2, is performed as a function of transverse momentum pT in the 0–20% high-multiplicity interval at both forward (2.032 GeV/c. The v2 coefficient of incl

The most precise measurements to date of the HΛ3 lifetime τ and Λ separation energy BΛ are obtained using the data sample of Pb-Pb collisions at sNN=5.02 TeV collected by ALICE at the LHC. The HΛ3 is reconstructed via its charged two-body mesonic decay channel (HΛ3→He3+π- and the charge-conjugate process). The measured values τ=[253±11(stat)±6(syst)] ps and BΛ=[102±63(stat)±67(syst)] keV are compa

Multidimensional Magnetic Resonance Imaging (MRI) is a versatile tool for microstructure mapping. We use a diffusion weighted inversion recovery spin echo (DW-IR-SE) sequence with spiral readouts at ultra-strong gradients to acquire a rich diffusion–relaxation data set with sensitivity to myelin water. We reconstruct 1D and 2D spectra with a two-step convex optimization approach and investigate a

Crime fiction has become one of Sweden's biggest cultural exports. In this chapter, we discuss how individual crime fiction writers are used as role models for how creative industries should function in both local and global contexts. They appear to be at the forefront of outreach to an international audience, how to market books and your own author brand through events, and how to make a successf

We investigated the change of the prevalence of noncommunicable diseases (NCDs) in Bangladesh from 2011 to 2018 across different socioeconomic groups as well as the factors associated with the changes in prevalence. We used the two waves of the Bangladesh Demographic and Health Surveys conducted in 2011 and 2017–2018. Modified Poisson regression model was used to estimate the prevalence rate and r

Single-photon emission computed tomography systems distinguish radionuclides by using multiple energy windows. For cadmium zinc telluride (CZT) detectors, the energy spectrum has a low-energy tail leading to additional crosstalk between the radionuclides. Previous work developed models to correct the scatter and crosstalk for CZT-based dedicated cardiac systems with similar 99mTc/123I tracer distr

Rural communities tell us the story of a thousand of years of collaboration between nature, culture and humans. The current Covid-19 pandemic is considerably threating rural areas, posing challenges exacerbated by low available financial resources, not easily accessible health services and greater isolation. Rural areas are also considered safe shelters characterized by better daily living conditi

Rural gentrification studies are often centred around socio-economic impacts, while rarely look at gentrifiers tangible effects on the landscape. This study has tried to distinguish a connection between socio-economic development and the landscape. It has thereby provided an overview of rural gentrification indicators based on a comparison between previous case studies. It is suggested that define