Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and cellular mechanism(s) by which Aβ and/or its precursor protein, the amyloid precursor protein (APP) can affect synapses remains unclear. Interestingly, early hyperexcitability has been described in human AD and mouse models of AD

Background: To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point-of-care (POC) rapid RT-PCR (VitaPCR) were i

Recension av Hans Christner (red.) Marinmålarna. Havet, skeppet och sjömannen i konsten från Jacob Hägg till Lars Lerin. Historiska Media / Sjöhistorisk Årsbok 2020-2021

Recension av Bengt Lindroth, Vi som inte var med i kriget. Om Sverige, Norden, Europa och coronan.

Cyclin dependent kinase 1 (CDK1) has long been known to drive the cell cycle and to regulate the division and differentiation of cells. Apart from its role in mitosis regulation, it also exerts multiple functions as a protein kinase, including engagement in cell death, possibly via a cell cycle-independent mechanism. The latter is suggested, since CDK1 re-expression can be found in non-dividing an

OBJECTIVES: Substandard and falsified medical products are, according to the World Health Organization, a global threat to public health. To evaluate if community pharmacy employees can guide the public to safer medication purchases, their knowledge and experience about SF medical products was examined.METHODS: A digital questionnaire was distributed to the five dominating pharmacy companies in Sw

Industrial relations vary between European countries. For member countries of the European union, the role of European legislation, labour law and other policy measures play a central and co-ordinating role. The current policy development from the European Commission on minimum wages illustrates the tensions between on one hand the Nordic model with collective agreements and a stronger role from s

The aim of this work was to evaluate the capability of diffuse reflectance spectroscopy to distinguish malignant liver tissues from surrounding tissues, and to determine whether an extended wavelength range (450–1550 nm) offers any advantages over using the conventional wavelength range. Furthermore, multivariate analysis combined with a machine learning algorithm, either linear discriminant analy

Jerk, the derivative of acceleration with respect to time, is a physical concept of great practical significance. However, this concept is rarely mentioned in textbooks and is often neglected in physics education. This paper describes how the concept of jerk can be easily introduced in the study of the dynamics of falling bodies, which are significantly affected by air resistance. In this regard,

This study examines the ways in which Web2.0 sociotechnical affordances of far-right metapolitics are gendered. Specifically, I focus on a key Swedish far-right entity that is not only an extensive publisher of far-right intellectual output, but also organizes a political salon that unites various actors from the European transnational far-right ecosystem. My explicit interests are in the performa

Ciguatera Poisoning (CP) is caused by consumption of fish or invertebrates contaminated with ciguatoxins (CTXs). Presently CP is a public concern in some temperate regions, such as Macaronesia (North‐Eastern Atlantic Ocean). Toxicity analysis was performed to characterize the fish species that can accumulate CTXs and improve understanding of the ciguatera risk in this area. For that, seventeen fis

Over the last decade, knowledge has significantly increased on the taxonomic identity and distribution of dinoflagellates of the genera Gambierdiscus and Fukuyoa. Additionally, a number of hitherto unknown bioactive metabolites have been described, while the role of these compounds in ciguatera poisoning (CP) remains to be clarified. Ciguatoxins and maitotoxins are very toxic compounds produced by

In the last decade, several outbreaks of ciguatera fish poisoning (CFP) have been reported in the Canary Islands (central northeast Atlantic Ocean), confirming ciguatera as an emerging alimentary risk in this region. Five Gambierdiscus species, G. australes, G. excentricus, G. silvae, G. carolinianus and G. caribaeus, have been detected in macrophytes from this area and are known to produce the ci

Dinoflagellate species of the genera Gambierdiscus and Fukuyoa are known to produce ciguatera poisoning-associated toxic compounds, such as ciguatoxins, or other toxins, such as maitotoxins. However, many species and strains remain poorly characterized in areas where they were recently identified, such as the western Mediterranean Sea. In previous studies carried out by our research group, a G. au

Gambierdiscus and Fukuyoa are genera of toxic dinoflagellates which were mainly considered as endemic to marine intertropical areas, and that are well known as producers of ciguatoxins (CTXs) and maitotoxins (MTXs). Ciguatera poisoning (CP) is a human poisoning occurring after the consumption of fish or more rarely, shellfish containing CTXs. The presence of these microalgae in a coastal area is a

Ciguatera Poisoning (CP) is a human food-borne poisoning that has been known since ancient times to be found mainly in tropical and subtropical areas, which occurs when fish or very rarely invertebrates contaminated with ciguatoxins (CTXs) are consumed. The genus of marine benthic dinoflagellates Gambierdiscus produces CTX precursors. The presence of Gambierdiscus species in a region is one indica

This chapter analyses the use of violence in the name of religion. Religious extremism is an ideology of certain movements, groups, individuals in denominations and religious organizations, characterised by adherence to extreme interpretations of dogma. It also involves methods of action by these parties to achieve their goals and spread their views and influence. The purpose of religious extremis

Osteoarthritis (OA) is the most common joint disease, where articular cartilage degradation is often accompanied with sclerosis of the subchondral bone. However, the association between OA and tissue mineralization at the nanostructural level is currently not understood. In particular, it is technically challenging to study calcified cartilage, where relevant but poorly understood pathological pro

The Einstein Telescope (ET), a wide-band, future third generation gravitational wave detector, is expected to have detection rates of ∼105 − 106 binary black hole (BBH) detections and ∼7 × 104 binary neutron star (BNS) detections in one year. The coalescence of compact binaries with a total mass of 20–100 M⊙, typical of BH-BH or BH-NS binaries, will be visible up to redshift z ≈ 20 and even higher