Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, hi

We propose and study a weakly convergent variant of the forward-backward algorithm for solving structured monotone inclusion problems. Our algorithm features a per-iteration deviation vector, providing additional degrees of freedom. The only requirement on the deviation vector to guarantee convergence is that its norm is bounded by a quantity that can be computed online. This approach offers great

Multi-junction photovoltaics approaches are being explored to mitigate thermalization losses that occur in the absorption of high-energy photons. However, the design of tandem cells faces challenges such as light reflection and parasitic absorption. Nanostructures have emerged as promising solutions due to their anti-reflection properties, which enhances light absorption. III-V nanowires (NWs) sol

Qatar 2022 has become a symbol of sportswashing, a flagpost for discussions about accountability, responsibility, and morality within different sport disciplines, football being a prime example. “Moral violation” has been listed as the crime surrounding sportswashing (Fruh, Archer & Wojtowicz 2023, 103). After frenzied use of the word in connection to the last football world cup 2022, there ca

Previous research has indicated an association between the presence of the vitamin D receptor (VDR) in breast cancer tissue and a favorable prognosis. This study aimed to further evaluate the prognostic potential of VDR located in the nuclear membrane or nucleus (liganded). The VDR protein levels were analyzed using immunohistochemistry in tumor samples from 878 breast cancer patients from Lund, S

Manual co-speech gestures can facilitate language comprehension, especially in adverse listening conditions. However, we do not know whether gestures influence simultaneous interpreters’ language comprehension in adverse listening conditions, and if so, whether this influence is modulated by interpreting experience, or by active simultaneous interpreting (SI). We exposed 24 interpreters and 24 bil

Aims: Grading of diastolic function can be useful, but indeterminate classifications are common. We aimed to invasively derive and validate a quantitative echocardiographic estimation of pulmonary artery wedge pressure (PAWP) and to compare its prognostic performance to diastolic dysfunction grading.Methods and results: Echocardiographic measures were used to derive an estimated PAWP (ePAWP) usingAims: Grading of diastolic function can be useful, but indeterminate classifications are common. We aimed to invasively derive and validate a quantitative echocardiographic estimation of pulmonary artery wedge pressure (PAWP) and to compare its prognostic performance to diastolic dysfunction grading.Methods and results: Echocardiographic measures were used to derive an estimated PAWP (ePAWP) using

Background: Gaming disorder (GD) has been introduced as a new diagnosis in the International Classification of Disease 11 (ICD-11). Currently, there's limited understanding of how various video games may differentially contribute to the risk of developing GD. The main aim of this study was to examine the relationship between individuals' game genre preferences, their preferred games' monetization

BACKGROUND: The wasabi receptor, also known as the Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel, is a potential target for development of repellents for insects, like the pine weevil (Hylobius abietis) feeding on conifer seedlings and causing damage in forestry. Heterologous expression of TRPA1 from pine weevil in the yeast Pichia pastoris can potentially provide protein for structur

En animerad film kring universell urformning och hållbar gestaltning av stadsmiljöer. I samarbete med Göteborgs stad.

A phase-field ductile fracture formulation for orthotropic paperboard materials is proposed, based on an anisotropic, multi-surface elastoplastic model describing the in-plane behavior of paperboard. A variational statement for the finite-step elastoplastic problem is extended to include the variational description of Griffith-type brittle fracture by a phase-field gradient term. The interaction b

Family reunification is, in the words of the European Union (EU) Family Reunification Directive (2003/86/EC), a ‘necessary way of making family life possible’ and preserving family unity. Yet, barriers exist which hinder refugees’ realisation of their right to family reunification. By taking the plight of Eritrean refugees in Europe as a pertinent case study, this paper shows the obstacles that “p