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A Critical Mapping of Practice-Based Research as Evidenced by Swedish Architectural Theses
This article presents an investigation that was funded by the Swedish Institute into the role of creative practice in architectural research as evidenced in Swedish doctoral theses. The sample was mapped and analysed in terms of clusters of interest, approaches, cultures of knowledge and uses of creative practice. This allowed the identification of the ontological, epistemological and methodologic
Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly similar to their bone marrow counterparts.
Mesenchymal stromal cells (MSC) are multipotent cells that can be isolated from a number of human tissues. In cancer, MSC have been implicated with tumor growth, invasion, metastasis, drug resistance and were even suggested as possible tumor-initiating cells in osteosarcoma (OS). However, MSC from OS and their possible tumor origin have not yet been thoroughly investigated. Therefore, primary OS m
Conodont biostratigraphy, and delta C-13 and delta S-34 isotope chemostratigraphy, of the uppermost Ordovician and Lower Silurian at Osmundsberget, Dalarna, Sweden
The previously established graptolite and chitinozoan Hirnanian-Telychian biostratigraphy in the unique Osmundsberget North outcrop in the Siljan region, south-central Sweden, is integrated with new conodont biostratigraphy and C-13(org), C-13(carb) and S-34(pyr) chemostratigraphy. At this locality, the middle Hirnantian (latest Ordovician) topmost part of the Boda Limestone is overlain by the lat
Glucagon dynamics during hypoglycaemia and food-re-challenge following treatment with vildagliptin in insulin-treated patients with type 2 diabetes.
To determine the effects of dipeptidyl peptidase-4 (DPP-4) inhibition on glucagon dynamics in patients with insulin-treated type 2 diabetes (T2D).
Flap Dynamics in Aspartic Proteases : A Computational Perspective
Recent advances in biochemistry and drug design have placed proteases as one of the critical target groups for developing novel small-molecule inhibitors. Among all proteases, aspartic proteases have gained significant attention due to their role in HIV/AIDS, malaria, Alzheimer's disease, etc. The binding cleft is covered by one or two β-hairpins (flaps) which need to be opened before a ligand can
Ultrafast photoinduced dynamics in quantum dot-based systems for light harvesting
Colloidal semiconductor nanocrystals, referred to as quantum dots, offer simple low-temperature solution-based methods for constructing optoelectronic devices such as light emitting diodes and solar cells. We review recent progress in the understanding of photoinduced processes in key components of a certain type of quantum dot solar cells where the dots sensitize a suitable metal oxide, such as Z
Gastrointestinal dysfunction in liver cirrhosis.
Patients with liver cirrhosis exhibit several features of gut dysfunction which may contribute to the development of cirrhosis complications as well as have an impact on nutritional status and health-related quality of life. Gastrointestinal symptoms are common in cirrhosis and their pathophysiology probably involves factors related to liver disease severity, psychological distress, and gut dysfun
Bumble bees show trait-dependent vulnerability to landscape simplification
Agricultural intensification has resulted in large-scale loss of bee pollinators, but while some species have been negatively affected others seem to endure changed conditions. It has been suggested that certain morphological, ecological and life-history traits make some species more vulnerable to landscape changes. Information on which traits make species vulnerable and why may aid conservation o
The Role of the Rituximab Partner Chemotherapy Regimen In Young Patients with Good Prognosis Diffuse Large B Cell Lymphoma (DLBCL) Results of the 6 Year Follow up of the Mint Study of the Mabthera International Trial (Mint) Group
A Novel System for Source Characterization and Controlled Human Exposure to Nanoparticle Aggregates Generated During Gas–Metal Arc Welding
Abstract in Undetermined The aim of this study was to achieve a method to perform detailed characterization and human exposure studies of nanosized and nanostructured aerosol particles. The source chosen was mild steel, active gas, arc welding fume. The setup consisted of a generation chamber, where welding can be performed, connected to an airtight stainless steel 22 m(3) exposure chamber. Instru
Search for excited leptons in proton-proton collisions at root s=7 TeV with the ATLAS detector
The ATLAS detector is used to search for excited leptons in the electromagnetic radiative decay channel l* -> l gamma. Results are presented based on the analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 2.05 fb(-1). No evidence for excited leptons is found, and limits are set on the compositeness scale Lambda as a function of the excited le
Messages from the morgue to rheumatology: from Chagas disease to giant cell arteritis.
Autopsy rates have fallen from over 50% to less than 10% in recent decades. The drastic decline creates uncertainty regarding causes of death and has negative effects for research, training, and patient safety, despite advances in imaging and laboratory testing. Rheumatology is as much at a loss as other specialties. Examples are given of important missed diagnoses revealed only at autopsy.
The missing media: The procedural rhetoric of computer games
Carl R. Woese in memoriam Obituary
STrengthening the Reporting of OBservational studies in Epidemiology: Molecular Epidemiology STROBE-ME. An extension of the STROBE statement
Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility, and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agents and the body components or processes. The need for improved reporting of scientific research led t
Genome-wide Association Study Identifies Loci at ATF7IP and KLK2 Associated with Percentage of Circulating Free PSA
BACKGROUND: Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor of risk for prostate cancer among men with modestly elevated level of total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value and diagnostic accuracy. MATERIALS/METHODS: To evaluate genetic determinants of %fPSA, we conducted a genome-wide ass
Food first! Theorising assets and actors in agroforestry: risk evaders, opportunity seekers and 'the food imperative' in sub-Saharan Africa
Despite widely recognised and well-established benefits, it is difficult to adopt the multifunctional activity of agroforestry into the landscape and lifeworld of small-scale agriculture, if poverty, itself a main reason for adopting agroforestry, stands in its way. Based on participant observations and interviews with small-scale farmers in western Kenya, we explore and theorise agroforestry adop
Evaluation of pre-PCR processing approaches for enumeration of Salmonella enterica in naturally contaminated animal feed.
Three pre-PCR processing strategies for the detection and/or quantification of Salmonella in naturally contaminated soy bean meal were evaluated.
A new route for the synthesis of methacrylic acid from 2-methyl-1,3-propanediol by integrating biotransformation and catalytic dehydration
Methacrylic acid was produced in high yield by an integrated process involving bioconversion of 2-methyl-1,3-propanediol (2M1,3PD) to 3-hydroxy-2-methylpropionic acid (3H2MPA) via 3-hydroxy-2-methylpropanal (3H2MPAL), and catalytic dehydration of the resulting acid. Whole cells of Gluconobacter oxydans grown on glycerol-based culture medium were used as the catalyst for oxidative biotransformation