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Studies on anti-dsDNA Antibodies and other potential biomarkers in Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation involving many organ systems. The etiology is unknown and the pathogenesis has not been fully elucidated. Impairments of the immune system and of the mechanisms regulating cell death are commonly seen in SLE patients. Autoantibodies, in particular anti-dsDNA antibodies, are considered hallmarks of SLE, but the ideal biomar

European Trauma: Governance and the Psychological Moment

This article examines the unfolding of traumas as structural and sociopsychological narratives focused on the bordering of identity and the governing of past present and future. Proceeding from a Lacanian conception of trauma and a Foucauldian understanding of governmentality, the analysis is centered on hegemonic counternarratives, even crises, involving the bordering of both Islam/Muslim identit

Metaphorical Coherence : Studies in Seneca's Epistulae Morales

Earlier research has treated the metaphors and similes in Seneca’s Epistulae Morales too much as separate units. In this study, Dr Aron Sjöblad argues that we rather ought to concentrate on the way they interact with each other. In the first chapter, Sjöblad demonstrates that a single source domain, the human body, unites many of the metaphors that have been treated as distinct groups in earlier r

On the well-posedness of the Maxwell system for linear bianisotropic media

The time dependent Maxwell system is supplemented with the constitutive relations of linear bianisotropc media and is treated as a neutral integro-differential equation in a Hilbert space. By using the theory of abstract Volterra equations and strongly continuous semigroups we obtain general well-posedness results for the corresponding mathematical problem.

Chronic non-bloody diarrhoea: a prospective study in Malmö, Sweden, with focus on microscopic colitis.

Chronic non-bloody diarrhoea affects up to 5% of the population. Microscopic colitis is one of the most common causes, encompassing the subtypes collagenous colitis and lymphocytic colitis. The diagnosis of microscopic colitis is made by histological examination of colonic mucosal biopsy specimens. The aim of this investigation was to determine whether laboratory parameters or questions about dise

Increased risk of atrial fibrillation in patients with coeliac disease: a nationwide cohort study

Aims Inflammatory markers are established risk factors for atrial fibrillation (AF), but the role of autoimmune diseases is unknown. The aim of the study was to examine the association between coeliac disease (CD) and AF in a large cohort of patients with biopsy-verified CD. Methods and results We identified 28 637 patients with CD through biopsy reports (defined as Marsh 3: villous atrophy) from

Accuracy and Precision of Radioactivity Quantification in Nuclear Medicine Images

The ability to reliably quantify activity in nuclear medicine has a number of increasingly important applications. Dosimetry for targeted therapy treatment planning or for approval of new imaging agents requires accurate estimation of the activity in organs, tumors, or voxels at several imaging time points. Another important application is the use of quantitative metrics derived from images, such

Co-selection for antibiotic tolerance in Cu-polluted soil is detected at higher Cu-concentrations than increased Cu-tolerance

Co-selection for antibiotic tolerance in Cu polluted soils was studied in a laboratory experiment. Pollution Induced Community Tolerance (PICT) of the bacterial community was estimated using leucine incorporation. PICT was found in Cu polluted soils to tetracycline (>= 8 mmol Cu kg(-1)), tylosin (>= 16 mmol Cu kg(-1)) and vancomycin (>= 16 mmol Cu kg(-1)). PICT to the antibiotics was found at high

Expression of caspase-3 predicts prognosis in advanced noncardia gastric cancer

There is strong evidence that tumor growth is not only a result of uncontrolled cell proliferation but also of decreased apoptosis. Caspase-3 is a member of interleukin-1 beta-converting enzyme which is involved in the induction of apoptosis. Data on the expression of caspase-3 in patients with gastric cancer and its association with patient outcome are somewhat contradictory. We aimed to investig

Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis

Objective. To investigate the risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF) inhibitors, compared to a standard RA population. Methods. Patients were recruited from a regional register, which includes over 90% of patients with RA started on TNF blockers in 1999 or later, and a local community based cohort of RA patients, est

Ab Initio Density Fitting: Accuracy Assessment of Auxiliary Basis Sets from Cholesky Decompositions

The accuracy of auxiliary basis sets derived by Cholesky decompositions of the electron repulsion integrals is assessed in a series of benchmarks on total ground state energies and dipole moments of a large test set of molecules. The test set includes molecules composed of atoms from the first three rows of the periodic table as well as transition metals. The accuracy of the auxiliary basis sets a

How nitrogen and sulphur addition, and a single drought event affect root phosphatase activity in Phalaris arundinacea

Conservation and restoration of fens and fen meadows often aim to reduce soil nutrients, mainly nitrogen (N) andphosphorus (P). The biogeochemistry of P has received much attention as P-enrichment is expected to negatively impact on species diversity in wetlands. It is known that N, sulphur (S) and hydrological conditions affect the biogeochemistry of P, yet their interactive effects on P-dynamics

Preruptive effect of NaF tablets on caries in children from 12 to 17 years of age

The purpose of this study was to evaluate the preeruptive effect of NaF tablets on caries in proximal surfaces of permanent molars and premolars. The material consisted of 47 subjects who had consumed fluoride tablets for a minimum of 5 yr between 1/2 and 6 yr of age in accordance with recommendations from the National Swedish Board of Health and Welfare (F+-group) and 69 comparable children who h

Differences in prevalence and treatment of Pseudomonas aeruginosa in cystic fibrosis centres in Denmark, Norway and Sweden

Background: Chronic Pseudomonas aeruginosa (PA) infection causes increased morbidity and mortality in cystic fibrosis (CF). This study aimed to answer the following questions: Does the prevalence of chronic infection with PA differ between the CF centres in Scandinavia? Which differences exist concerning segregation and treatment of PA? Methods: 989 patients (86%) from all eight CF-centres in Scan