In 2017, the International Headache Society convened a Global Patient Advocacy Summit (GPAS-1) to begin a collaborative effort involving patients, patient advocates, patient advocacy organizations, healthcare professionals, scientists, professional pain, neurology, and headache societies, pharmaceutical manufacturers, and regulatory agencies to advance issues of importance to patients affected by

Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson's disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nature of the disease. In this study, we establish a humanized transplantation model of PD that better

Background: In chronic obstructive pulmonary disease (COPD), both the time needed for patients to gain symptom improvement with long-acting bronchodilator therapy and whether an early response is predictive of a sustained response is unknown. This study aimed to investigate how quickly meaningful symptom responses are seen in patients with COPD with bronchodilator therapy and whether these respons

Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate substrates by enzymatic cleavage and, on the basis of their activities, have been demonstrated to play a role in ageing. Thus, in order to gain insight into the pathophysiology of ageing and to identify new markers of longevity, we analysed the activity levels of MMP-2 and MMP-9 in association with some relevant h

Aims: Worldwide, smokeless-tobacco use is a major risk factor for oral cancer. Evidence regarding the particular association between Swedish snus use and oral cancer is, however, less clear. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between snus use and oral cancer. Methods: A total of 418,369 male participants from nine c

We introduce a new model of near-forward elastic proton–(anti)proton scattering at high energy based on the modern formulation of Pomeron and Odderon in terms of Wilson lines and generalized transverse momentum dependent distributions. We compute the helicity-dependent elastic amplitudes ϕ1 , 2 , 3 , 4 , 5 in this model and study their energy dependence from the nonlinear small-x evolution equatio

In late 2019, the Intergovernmental Panel on Climate Change (IPCC) released their much-awaited Special Report on the Ocean and Cryosphere in a Changing Climate (SROCC). High mountain areas, polar regions, low-lying islands and coastal areas, and ocean and marine ecosystems, were separately dealt by experts to reveal the impacts of climate change on these regions, as well as the responses of the na

Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological lidar to monitor a half-kilometer static transect adjacent to a Tanzanian village

The Rivet library is an important toolkit in particle physics, and serves as a repository for analysis data and code. It allows for comparisons between data and theoretical calculations of the final state of collision events. This paper outlines several recent additions and improvements to the framework to include support for analysis of heavy ion collision simulated data. The paper also presents

Remote-sensing-based machine learning approaches for water quality parameters estimation, Secchi Disk Depth (SDD) and Turbidity, were developed for the Valle de Bravo reservoir in central Mexico. This waterbody is a multipurpose reservoir, which provides drinking water to the metropolitan area of Mexico City. To reveal the water quality status of inland waters in the last decade, evaluation of MER

A model independent Lévy expansion method is introduced to describe nearly Lévy shaped squared moduli of Fourier transforms. We apply this method to precisely characterize the most recent elastic scattering data of proton-proton collisions at $$\sqrt s = 13$$ TeV. The results reveal a substructure of protons, which is found to be significantly larger and darker in high energy proton-proton collisi

In this paper I want to examine whether the everyday distribution of music induces a mode of listening that modifies people’s relations to the history of music or not. It is indisputable that the diverse landscape of digital music platforms and music streaming services have an effect on how we perceive music as cultural texts, as commodities and as aesthetic objects. We listen on the go while at t

The Paleocene-Eocene Thermal Maximum (PETM, ca. 56 Ma) is marked by a negative carbon isotope excursion (CIE) and increased global temperatures. The CIE is thought to result from the release of 13C-depleted carbon, although the source(s) of carbon and triggers for its release, its rate of release, and the mechanisms by which the Earth system recovered are all debated. Many of the proposed mechanis

Here we report on the impact of reducing the crystalline size on the structural and magnetic properties of γ-Fe2O3 maghemite nanoparticles. A set of polycrystalline specimens with crystallite size ranging from ~2 to ~50 nm was obtained combining microwave plasma synthesis and commercial samples. Crystallite size was derived by electron microscopy and synchrotron powder diffraction, which was used

Background Although previous studies suggest similar patient survival for peritoneal dialysis (PD) and haemodialysis (HD), PD use has decreased worldwide. We aimed to study trends in the choice of first dialysis modality and relate these to variation in patient and technique survival and kidney transplant rates in Europe over the last 20 years. Methods We used data from 196 076 patients within the