OBJECTIVE - To investigate the association of GAD (65-kDa) autoantibodies (GAD65-Abs) and IA-2 autoantibodies (IA-2-Abs) with human leukocyte antigen (HLA)-DQ and insulin gene (INS) risk markers in patients with recent-onset IDDM and their siblings. RESEARCH DESIGN AND METHODS - Blood was sampled from 608 recent-onset IDDM patients and 480 siblings, aged 0-39 years and consecutively recruited by t

A class of plane stress problems for incompressible materials is studied. The class concerns problems for unidirectionally reinforced thin sheets under quasi-static loading conditions. An incremental theory of plasticity and an isotropic yield condition is assumed. It is demonstrated how a corresponding antiplane strain problem can be identified, Thus solutions are readily found to a variety of prA class of plane stress problems for incompressible materials is studied. The class concerns problems for unidirectionally reinforced thin sheets under quasi-static loading conditions.

Ecological compensation is the latest member of a growing family of concepts aimed at reducing degradation of environmental quality. This and other concepts of the family – like ecosystem services, green infrastructure, and nature-based solutions – have been subject to a range of different interpretations and subsequent implementation practices. The result is a complex governance system with uncle

Background: The influence of gender on bipolar disorder is controversial and it is unclear if inpatient care differs between men and women. Here, we investigate for gender differences in the inpatient length of stay for Swedes admitted for bipolar disorder and explore other factors that could explain any observed association. Methods: Admission data were extracted from the Swedish National Patient

Background: Careful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa). Objective: Using Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation. Design, setting, and participants: We compared data from 10 296 men on AS from 21 centres across 12 co

Frågan efter gudstjänstens mening kan inte ges något enkelt svar, den är alldeles för stor. Men det är en fråga att ständigt återvända till – för att reflektera över om vi rätt har förstått denna mening, om vi förklarar den bra och om våra gudstjänster speglar den på ett adekvat sätt.Till hjälp för denna nödvändiga reflektion erbjuder årets årsbok sex artiklar som bearbetar olika aspekter av fråga

The γ-backscattering imaging techniques are alternative methods to the transmission techniques to determine the amount and distribution of matter in objects. Images obtained with a γ-backscattering device are presented. In order to increase the understanding of the image formation process and to assist in the data analysis, a simulation of the camera was developed using the Geant4 simulation toolk

A fundamental challenge in medical microbiology is to characterize the dynamic protein-protein interaction networks formed at the host-pathogen interface. Here, we generate a quantitative interaction map between the significant human pathogen, Streptococcus pyogenes, and proteins from human saliva and plasma obtained via complementary affinity-purification and bacterial-surface centered enrichment