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Image-based analysis of breast tumour growth rate may help optimize breast cancer screening and diagnosis. It may improve the identification of aggressive tumours and suggest optimal screening intervals. Virtual clinical trial (VCT) is a simulation-based method used to evaluate and optimize medical imaging systems and design clinical trials. Our work is motivated by desire to simulate multiple scr
Objective: To describe perioperative adverse events, fertility and obstetric outcome, following a robot assisted laparoscopic approach for treating Cesarean scar pregnancies (CSP). Study Design: A retrospective case series of 14 consecutive women with a CSP and a wish for and attempts towards subsequent pregnancies, having undergone minimal invasive surgical treatment at two tertiary referral Swed
The literature on sustainable tourism is scant, particularly in the least developed countries. Very few studies touch upon the concept and no holistic theoretical or conceptual frameworks around the idea of sustainable tourism have been formulated. This study aims at exploring the role of tour operators in developing sustainable tourism in Pakistan and how the tour operators (TOs) conceive their r
Ett ekologisk, ekonomiskt och socialt hållbart nyttjande av jordens resurser är en viktig förutsättning för en hållbar samhällsutveckling och inte minst för vår förmåga att tackla och anpassa oss till aktuella och framtida utmaningar, såsom klimatförändringar eller pandemier. En av de stora frågorna kopplat till detta är markanvändningen: Hur vi ska använda våra begränsade markresurser, så att vi
This article addresses issues surrounding the social construction of internet addiction, focusing on conceptualisations of reality, escape, hope, and time. Drawing on a critical realist account of semiosis, the framing of internet addiction in China is analysed using the documentary film Web Junkie as an empirical pivot and point of departure. A contextual overview of relations, interests, and ten
Air pollution causes premature mortality and morbidity globally, but these adverse health effects occur over proportionately in low-and middle-income countries. Lack of both air pollution data and knowledge of its spatial distribution in African countries have been suggested to lead to an underestimation of health effects from air pollution. This study aims to measure nitrogen oxides (NOx), as wel
Kortfattad framställning av Lunds universitets myndighetsarkivs organisatoriska, innehållsliga och lokalmässiga historia från 1600-tal till i dag samt en redogörelse för den nuvarande arkivorganisationen inom Sektionen Juridik och dokumenthantering och dess huvudsakliga arbetsuppgifter.
Despite the fact that the laser-cooling method is a well-established technique to obtain ultracold neutral atoms and atomic cations, it has rarely if ever been applied to atomic anions due to the lack of suitable electric-dipole transitions. Efforts of more than a decade have until recently only resulted in La- as a promising anion candidate for laser cooling, but our previous work [Tang et al., P
Amplification of fibroblast growth factor receptor 1 (FGFR1) in non-small cell lung cancer (NSCLC) has been considered as an actionable drug target. However, pan-FGFR tyrosine kinase inhibitors did not demonstrate convincing clinical efficacy in FGFR1-amplified NSCLC patients. This study aimed to characterise the molecular context of FGFR1 expression and to define biomarkers predictive of FGFR1 in
With the increasing demand for blood transfusions, the production of human hemoglobin (Hb) from sustainable sources is increasingly studied. Microbial production is an attractive option, as it may provide a cheap, safe, and reliable source of this protein. To increase the production of human hemoglobin by the yeast Saccharomyces cerevisiae, the degradation of Hb was reduced through several approac
Mobility restrictions are among actions to prevent the spread of the COVID-19 pandemic and have been pointed as reasons for improving air quality, especially in large cities. However, it is crucial to assess the impact of atmospheric conditions on air quality and air pollutant dispersion in the face of the potential variability of all sources. In this study, the impact of mobility restrictions on
‘Covert’ cerebral small vessel disease (ccSVD) is common on neuroimaging in persons without overt neurological manifestations, and increases the risk of future stroke, cognitive impairment, dependency, and death. These European Stroke Organisation (ESO) guidelines provide evidence-based recommendations to assist with clinical decisions about management of ccSVD, specifically white matter hyperinte
Previous studies suggest that the effects of ethanol on carbachol-stimulated I(1,4,5)P3 formation and on the number of mAChRs may be independent of each other. The aim of this work was to further study this hypothesis. Human neuroblastoma SH-SY5Y cells were used as a model system. Acute exposure of the cells to 100 mM ethanol induced a decrease in [3H]N-methylscopolamine ([3H]NMS) binding at 30 se
Immunocytochemistry and in situ hybridization revealed abundant secretin expressing cells on duodenal villi with a gradual decrease throughout the small intestines of the rat. They were absent in pancreas, stomach and colon. Secretin caused relaxation of rat intestinal longitudinal muscle in vitro. Studies on colon revealed that the secretin-evoked response was unaffected by apamin, tetrodotoxin,
The generation of attosecond pulse trains at free-electron lasers opens new opportunities in ultrafast science, as it gives access, for the first time, to reproducible, programmable, extreme ultraviolet (XUV) waveforms with high intensity. In this work, we present a detailed analysis of the theoretical model underlying the temporal characterization of the attosecond pulse trains recently generated
This thesis presents and describes the development of an online freely accessible software called Multi-Scattering for the computational modeling of light propagation in scattering and absorbing media. The model is based on the use of the Monte Carlo method, where billions of photon packets are being launched and tracked through simulated cubic volumes. The software also includes features for mode
The global pressure for excellence has boosted the relevance of the teaching–research relationship. Specifically, the management of teaching and research activities represents an important challenge because of time and resource limitations, especially for junior researchers. The traditionally polarized streams in the literature provide arguments to defend three types of relationship between teachi
Climate change affects global agricultural production and threatens food security. Faster phenological development of crops due to climate warming is one of the main drivers for potential future yield reductions. To counter the effect of faster maturity, adapted varieties would require more heat units to regain the previous growing period length. In this study, we investigate the effects of variet
Observational studies exploring whether there is a nonlinear effect of blood pressure on cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be overcome by leveraging randomly allocated genetic variants in nonlinear Mendelian randomization analyses. Based on their association with blood pressure traits in a genome-wide association study of 299 024 European ancestry i
Objective: Anti-beta 2 glycoprotein I IgA is a common isotype of anti-beta 2 glycoprotein I in SLE. Anti-beta 2 glycoprotein I was not included in the American College of Rheumatology (ACR) SLE classification criteria, but was included in the Systemic Lupus International Collaborating Clinics (SLICC) criteria. We aimed to evaluate the prevalence of anti-beta 2-glycoprotein I IgA in SLE versus othe
