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Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Vari

Changing Epidemiology of Hypoplastic Left Heart Syndrome : Results of a National Swedish Cohort Study

Background Norwood surgery provides a palliative surgical option for hypoplastic left heart syndrome and has been available in Sweden since 1993. The practice of prenatal ultrasound screening was gradually implemented in the same era, resulting in an increased prenatal detection rate. Our primary aims were to study changes in the incidence of live births, prenatal detection rate, and the terminati

Pirqei deRabbi Eliezer : Structure, Coherence, Intertextuality

In Pirqei deRabbi Eliezer: Structure, Coherence, Intertextuality Katharina E. Keim offers a description of the literary character of Pirqei deRabbi Eliezer, an enigmatic work of the late-eighth-to-early-ninth centuries CE. Katharina E. Keim explores the work’s distinctive literary features through an analysis of its structure and coherence. These literary features, when taken together with the wor

Prolonged Tpeak-Tend interval is associated with ventricular fibrillation during reperfusion in ST-elevation myocardial infarction

Aim: Ventricular fibrillation (VF) during reperfusion in ST-elevation myocardial infarction (STEMI) is associated with increased in-hospital mortality. Dispersion of ventricular repolarization contributes to ventricular vulnerability during ischemia. Tpeak-Tend interval was proposed as a ventricular repolarization dispersion marker, however its value for prediction of reperfusion VF remains uncert

Imitation recognition and its prosocial effects in 6-month old infants

The experience of being imitated is theorised to be a driving force of infant social cognition, yet evidence on the emergence of imitation recognition and the effects of imitation in early infancy is disproportionately scarce. To address this lack of empirical evidence, in a within-subjects study we compared the responses of 6-month old infants when exposed to ipsilateral imitation as opposed to n

On the optimal plasmonic resonances in lossy media

An optimal plasmonic resonance is derived for small homogeneous and isotropic inclusions in a lossy surrounding medium. The optimal resonance is given in terms of any particular eigenmode (electrostatic resonance) associated with the double-layer potential for a smooth, but otherwise arbitrary surface.

Health related quality of life in individuals transferred from a needle exchange program and starting opioid agonist treatment

Background. Opioid agonist treatment (OAT), for the treatment of heroin dependence, has been reported to improve overall health and lower mortality. Drug use and retention in treatment have often been used as measures of treatment success. More recently, however, researchers have suggested that measurements of quality of life should be an outcome in substance use treatment evaluations. In a recent