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Experimental and computational efforts are constantly made to elucidate mechanisms controlling cell fate decisions during development and reprogramming. One powerful computational method is to consider cell commitment and reprogramming as movements in an energy landscape. Here, we develop Computation of Energy Landscapes of Logical Gene Networks (CELLoGeNe), which maps Boolean implementation of ge
Including the voices and knowledge of service users is essential for developing recovery-oriented and evidence-based mental health services. Recent studies have however, suggested that challenges remain to the legitimization of user knowledge in practice. To further explore such challenges, a co-production study was conducted by a team of researchers and representatives from user organizations in
The RNA genome of SARS-CoV-2 contains a 5′ cap that facilitates the translation of viral proteins, protection from exonucleases and evasion of the host immune response1–4. How this cap is made in SARS-CoV-2 is not completely understood. Here we reconstitute the N7- and 2′-O-methylated SARS-CoV-2 RNA cap (7MeGpppA2′-O-Me) using virally encoded non-structural proteins (nsps). We show that the kinase
Background: Prostate cancer has a multifaceted treatment pattern. Evidence is lacking for optimal treatment sequences for metastatic castration-resistant prostate cancer (mCRPC). Objective: To increase the understanding of real-world treatment pathways and outcomes in patients with mCRPC. Design, setting, and participants: A prospective, noninterventional, real-world analysis of 3003 patients with
That time is a valuable commodity in our contemporary society preoccupied with productivity and the speed afforded by digital technologies is well established in the marketing literature. Two streams of literature have emerged: one associating status with lack of time and busyness and the other linking status to the ability to enjoy slowness. How consumers’ perceptions of time unfold beyond a fast
Neutron imaging is used for direct observation of evolving water–air and deuterated water–normal water exchanges in flow experiments performed on a laboratory-deformed, microporous laminated limestone, an extremely fine-textured rock altered by arrays of superposed fractures generated in a rock mechanics apparatus. The neutron images document significant, evolving, water speed and flow direction v
Philosophers of science have in recent years become increasingly interested in the notion of interdisciplinarity. One important form interdisciplinarity can take is that of a dynamic exchange of problems and solutions between disciplines— what has recently been called problem-feeding. On this model problems arising within specific disciplines are sometimes solved more effectively by, or in collabo
Bröstcancer är vanligt förekommande bland kvinnor, en av tio kvinnor får en bröstcancerdiagnos under sin livstid. Upplevelsen av bröstcancer är en komplex process, som innebär ett flertal sammanlänkade stressfulla händelser. Det är därför tydligt att sättet personen reagerar på sådana stressorer kan ha en betydande påverkan på både fysisk och psykisk hälsa. Resiliens är ett konstrukt som innefattaBreast cancer is a common event among women, one in ten women receiving a breast cancer diagnosis in their lifetime. The experience of breast cancer is a complex process that entails a multitude of interlinked potentially highly stressful events. It is thus evident that the manner in which one reacts to such stressors can have a substantial impact on both physical and mental health. Resilience is
The mechanisms leading to the occurrence of extreme weather and climate events are varied and complex. They generally encompass a combination of dynamic and thermodynamic processes, as well as drivers external to the climate system, such as anthropogenic greenhouse gas emissions and land use change. Here we present the ExtremeX multi-model intercomparison experiment, which was designed to investig
The SARS-CoV-2 Omicron (B.1.1.529) variant has been associated with lesssevere acute disease, however, concerns remain as to whether long-termcomplaints persist to a similar extent as for earlier variants. Studying 1 323 145persons aged 18-70 years living in Norway with and without SARS-CoV-2infection in a prospective cohort study, we found that individuals infected withOmicron had a similar risk
Heart failure (HF) is a leading cause of death in both men and women. However, risk factors seem to differ for men and women and significant gaps in sex-specific knowledge exist. Mitochondria are critical for cardiomyocytes and in this study, we investigated the role of baseline mitochondrial DNA copy number (mtDNA-CN) in HF incidence in middle-aged women and its possible role in the association b
Food insecurity early warning can provide time to mitigate unfolding crises; however, drought remains a large source of uncertainty. The challenge is to filter unclear or conflicting signals from various climatic and socio-economic variables and link them to food security outcomes. Integrating lag-1 autocorrelation diagnostics into remotely sensed observations from the Soil Moisture Active Passive
Famine early warning systems are fundamental for anticipating and preventing food security crises. These systems require diverse socio-economic, climate and other environmental indicators. However, the uncertainty that is inherent in climate forecasts and other early warning data can influence the accuracy of early warning systems. Inaccurate forecasts result in ineffective preparedness and poor r
Early warning systems are essential tool for humanitarian preparedness and response. The diversity of inputs required, ranging from agricultural production estimates to market price variability and weather forecasts, means that interpreting food security signals is not an easy task. Each of these inputs is fraught with uncertainty which analysts need to assess when making projections about future
This paper examines how organizations and society learn from disasters. While learning can and does take place, the depth of this learning is often superficial. The paper argues that lessons that are more fundamental are learnt with difficulty. In order to examine the aetiology of disasters and organizational learning from them, the paper presents a theoretical framework based on systems theory. C
Food security assessment in sub-Saharan Africa requires simultaneous consideration of multiple socio-economic and environmental variables. Early identification of populations at risk enables timely and appropriate action. Since large and widely dispersed populations depend on rainfed agriculture and pastoralism, climate monitoring and forecasting are important inputs to food security analysis. Sat
Remote sensing allows scientists to detect slowly evolving natural hazards such as agricultural drought. Famine early warning systems transform these data into actionable policy information, enabling humanitarian organizations to respond in a timely and appropriate manner. These life-saving responses are increasingly important: In 2006, one out of eight people did not have enough food to eat and 2
