Trends in carbon 1s ionization energies for the linear alkanes have been investigated using third-generation synchrotron radiation. The study comprises CH4, C2H6, C3H8, C4H10, C5H12, C6H14, and C8H18. Both inter- and intramolecular shifts in ionization energy have been determined from gas-phase spectra and ab initio calculations. The shifts are decomposed into initial-state and final-state contrib

The sulfur L-shell photoelectron spectrum of the carbon disulfide molecule has been studied using monochromated synchrotron radiation with a photon energy of 250 eV. The spectrum is atomic like, showing three major bands that can be associated with the sulfur (2p-1)2P3/2,12 and (2s-1)2S1/2 ionic states. A closer inspection shows that the 2P3/2 state is further split into two components separated b

We present direct evidence for ultra-fast dissociation of molecular water in connection photo-excitation of the O1s→4a1 resonance. The core-excited H2O molecules are shown to dissociate into core-excited O*H and neutral H on a time scale comparable to the core hole lifetime, i.e. a few femtoseconds. This conclusion is based on a resonant Auger study, qualitative arguments and ab initio calculation

Den här boken är en sammanfattning av mina 30 års erfarenhet av Electro-Pulse-Enhanced-Therapy vid behandling av maligna tumörer.Det första kapitlet är en kort historia över upptäckterna som ledde till klinisk användning av Electro-Pulse-Enhanced Cancer-terapi (EpECT). Redan i slutet av 1960-talet fann Sale att effekten av att inducera korta elektriska pulser på biologiska cellmembran gjorde dem ö

Background: The optimal antibiotic treatment length for infective endocarditis (IE) is uncertain. International guidelines recommend treatment duration of up to 6 weeks for patients with left-sided IE but are primarily based on historical data and expert opinion. Efficacies of modern therapies, fast recovery seen in many patients with IE, and complications to long hospital stays challenge the rati

Changes in dilution of wastewater to a treatment plant due to infiltration or surface runoff can have a great impact on treatment process performance. This paper presents a model-based approach in which realistic influent scenarios are generated and used as inputs to a dynamic plant-wide process model of the wastewater treatment plant. The simulated operation is subsequently evaluated using life-c

Human site-1-protease (S1P, MEROPS S08.8063), also widely known as subtilisin/kexin isozyme 1 (SKI-1), is a membrane bound subtilisin-related serine protease, that belongs to a group of nine mammalian proprotein convertases. Among these proteases, S1P displays unique substrate specificity, by showing preferred cleavage after non-basic amino acids. S1P plays a key role in a proteolytic pathway that

Procarboxypeptidase U [proCPU, thrombin-activatable fibrinolysis inhibitor (TAFI), EC 3.4.17.20] belongs to the metallocarboxypeptidase family and is a zymogen found in human plasma. ProCPU has been proposed to be a molecular link between coagulation and fibrinolysis. Upon activation of proCPU, the active enzyme (CPU) rapidly becomes inactive due to its intrinsic instability. The inherent instabil

Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides and activate a number of medically important nucleoside analogs. Here we report the structure of the Drosophila deoxyribonucleoside kinase with deoxycytidine bound at the nucleoside binding site and that of the human deoxyguanosine kinase with ATP at the nucleoside substrate binding site. Compared to the human kinase, the Drosophila ki

Over the last three years, the idea of a ‘post-truth society’ has become a common talking point. Politicians from around the world, from Europe to South America to the United States, have been labelled as ‘post-truth leaders’, with Donald Trump being portrayed as the standard bearer for this new kind of political discourse. This article suggests that post-truth leadership is nothing new. Ever sinc