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En skolbyggnads statusbedömning och renoveringsmöjligheter

Med utgångspunkt i Miljöbyggnad, det svenska miljöcertifieringssystemet, har en skolbyggnads status utvärderats. De bedömda indikatorerna inom energi, inomhusmiljö och material gav en bred och övergriplig bild av byggnadens skick och utvärderingen ger en bra grund för det fortsatta arbetet. Skolbyggnaden Kullagymnasiet i Höganäs, Skåne, bedöms nå certifieringsnivån brons, vilket minst motsvarar sa

Erfarenhetsåterföring vid renovering

Nationellt Renoveringscentrum (NRC) bildades 2013 för att arbeta med kunskapshöjning och informationsspridning om en effektiv renoveringsprocess. Centret siktar på att samla och föra vidare kunskap om hur renovering av befintlig bebyggelse kan genomföras både effektivt för involverade aktörer såväl som socialt, ekonomiskt och miljömässigt hållbart för samhället. Kunskap från både akademi och närin

MicroRNAs in Retinal Pathophysiology and Therapeutics

Following identification of tRNA and rRNA, the non-protein coding RNAs (ncRNAs) have been demonstrated to possess catalytic ribozyme functions (Cech et al., 1981; Guerrier-Takada et al., 1983). In recognition of the latter work, T.R. Cech and S. Altman were awarded the 1989 Noble Prize in Chemistry. Fire, et al. (1998) discovered that small double stranded RNA (ds RNA) silences the gene expression

Pioneers for the Basic Understanding of Usher syndrome

After the first description of the inherited nature of bimodal deaf-blindness disease in mid nineteenth century by pioneering ophthalmologists Albrecht von Graefe (May 22, 1828 ± July 20, 1870) and Richard Liebreich (June 30, 1830 - January 19, 1917) followed by its confirmation in early twentieth century from a larger number of patients by another pioneer ophthalmologist Charles Howard Usher (Mar

International Organisations, Authority, and the First Permanent Secretariats in the 19th Century

International organisations (IOs) play increasingly important roles in world politics. As states face more complex challenges they have joined together in IOs to solve their common problems. Yet once an IO has been created it may take on a life of its own, and it becomes difficult for its state founders to control what it does. Permanent secretariats populated by experts are one of the most importInternational organisations (IOs) play increasingly important roles in world politics. As states face more complex challenges they have joined together in IOs to solve their common problems. Yet once an IO has been created it may take on a life of its own, and it becomes difficult for its state founders to control what it does. Permanent secretariats populated by experts are one of the most import

Insufficient air supply rates in new build apartments with energy efficient ventilation : Including aspects of human perception and behaviour

A well-functioning ventilation system is significant in achieving a healthy indoor environment. The air supply rate is one of the important factors in reducing the pollutant levels indoors. A study of the indoor environment has been made in new built apartments with modern energy-efficient mechanical supply and exhaust ventilation systems. Several parameters have been measured including the air su

Sömnstörningar hos barn

Som ett led i regeringsuppdraget att ”Utvidga kunskapen om barns läkemedel och deras användning” anordnade Läkemedelsverket 2012 ett möte med representanter för barn- och ungdomspsykiatrin. Syftet var att identifiera kunskapsluckor samt föreslå speciella läkemedelsområden där det fanns behov av att sammanställa kunskap. Behandling av sömnstörningar hos barn var ett område som prioriterades.

Investigating parameters affecting the indoor temperature drop after a power cut : In-situ measurements and simulations

When looking at energy supply on a larger scale than to a single building, such as to a neighbourhood or a city, the combined effects of peak power demands can be seen to cause problems on the production side. These can be both economic and environmental and lead to the emission of greenhouse gases when fossil fuels are used to meet these peaks. Encouraging the demand side to reduce their power de

Investigating Dwellings' Response to Heating Power Cuts : Simulations and Field Tests

Reducing energy use, increasing the use of renewable energy sources, and adapting to stricter building regulations and certification systems – these are all examples of the challenges facing the building industry and society. Looking at the energy supply at a larger scale than a single building, like a neighborhood or a city, the stack effect of peak power demands can cause problems on the product

Psychometric evaluation of the Chinese version of the Person-centred Climate Questionnaire - Staff version (PCQ-S)

OBJECTIVES: The aim of the study was to evaluate the psychometric properties of a Chinese translation of the English version of the Person-centred Climate Questionnaire - Staff version (PCQ-S) for Chinese palliative care staff in a hospital context.DESIGN: This was a cross-sectional design. The 14-item English PCQ-S was translated and backtranslated using established procedures. Construct validity

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene : effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

The tumour suppressor p53 is one of the most important cancer genes. Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. We investigated the potential role of p53 in xenobiotic metabolism in vivo

Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. Cells that were TP53(+/+), TP53(+/-), TP53(-/-), TP53(

Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

We compared mouse embryonic stem (ES) cells and fibroblasts (MEFs) for their ability to metabolically activate the environmental carcinogens benzo[a]pyrene (BaP), 3-nitrobenzanthrone (3-NBA) and aristolochic acid I (AAI), measuring DNA adduct formation by (32)P-postlabelling and expression of xenobiotic-metabolism genes by quantitative real-time PCR. At 2 μM, BaP induced Cyp1a1 expression in MEFs