Sökresultat
Filtrera
Filtyp
Din sökning på "*" gav 531027 sökträffar
Nuclear Magnetic Resonance Spectroscopy Applied to (Intrinsically) Disordered Proteins
Protein Interactions with Microballoons: Consequences for Biocompatibility and Application as Contrast Agents
The role of proteins as the mediators of the interaction between engineered materials (biomaterials) and living systems has long been appreciated, but the subtleties and complexities introduced by changing surface curvature are only beginning to be understood. Thus, in implant devices, where the biomaterial is presented as a flat surface, a very limited range of proteins bind to the material, thes
Human plasma protein adsorption onto alumina nanoparticles relevant to orthopedic wear
PurposeWear of ceramic orthopedic devices generates nanoparticles in vivo that may present a different biological character from the monolithic ceramic from which they are formed. The current work investigated protein adsorption from human plasma on alumina nanoparticles and monolithic samples representative of both wear particles and the ceramic components as implanted.Materials and MethodsA phys
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Nanoparticles in a biological fluid (plasma, or otherwise) associate with a range of biopolymers, especially proteins, organized into the “protein corona” that is associated with the nanoparticle and continuously exchanging with the proteins in the environment. Methodologies to determine the corona and to understand its dependence on nanomaterial properties are likely to become important in bionan
Rapid and facile purification of apolipoprotein A-I from human plasma using thermoresponsive nanoparticles
Nanoparticles can be used to purify proteins from plasma. We report here the purification of apolipoprotein A-I (apoA-I) with high specificity from human plasma using copolymeric nanoparticles. We present an optimized protocol using 50:50 NiPAM:BAM copolymer nanoparticles with thermo-responsive properties as an affinity resin. Repeated pelleting and washing of nanoparticle-captured apoA-I is achie
Conserved ancestral tropical niche but different continental histories explain the latitudinal diversity gradient in brush-footed butterflies
The global increase in species richness toward the tropics across continents and taxonomic groups, referred to as the latitudinal diversity gradient, stimulated the formulation of many hypotheses to explain the underlying mechanisms of this pattern. We evaluate several of these hypotheses to explain spatial diversity patterns in a butterfly family, the Nymphalidae, by assessing the contributions o
Urbanization extends flight phenology and leads to local adaptation of seasonal plasticity in Lepidoptera
Urbanization is gaining force globally, which challenges biodiversity, and it has recently also emerged as an agent of evolutionary change. Seasonal phenology and life cycle regulation are essential processes that urbanization is likely to alter through both the urban heat island effect (UHI) and artificial light at night (ALAN). However, how UHI and ALAN affect the evolution of seasonal adaptatio
Solving Fredholm second-kind integral equations with singular right-hand sides on non-smooth boundaries
A numerical scheme is presented for the solution of Fredholm second-kind boundary integral equations with right-hand sides that are singular at a finite set of boundary points. The boundaries themselves may be non-smooth. The scheme, which builds on recursively compressed inverse preconditioning (RCIP), is universal as it is independent of the nature of the singularities. Strong right-hand-side si
COVID-19: Opportunities for interdisciplinary research to improve care for older people in Sweden
The emergence of COVID-19 has changed the world as we know it, arguably none more so than for older people. In Sweden, the majority of COVID-19-related fatalities have been among people aged ⩾70 years, many of whom were receiving health and social care services. The pandemic has illuminated aspects within the care continuum requiring evaluative research, such as decision-making processes, the stru
Brain injury after cardiac arrest
As more people are surviving cardiac arrest, focus needs to shift towards improving neurological outcomes and quality of life in survivors. Brain injury after resuscitation, a common sequela following cardiac arrest, ranges in severity from mild impairment to devastating brain injury and brainstem death. Effective strategies to minimise brain injury after resuscitation include early intervention w
Cardiovascular Proteomics : A Post Hoc Analysis from a Phase II Randomized Clinical Trial Comparing GnRH Antagonist vs GnRH Agonist among Men with Advanced Prostate Cancer
PURPOSE: Recent studies demonstrated reduced cardiovascular (CV) risk with gonadotropin-releasing hormone (GnRH) antagonist, yet the underlying mechanism remains undetermined. The objective of this study was to examine longitudinal changes over time in established CV related proteins among men treated with GnRH agonists vs GnRH antagonist. MATERIALS AND METHODS: We performed a proteomics analysis
Seasonal climate variations in the Baltic Sea during the Last Interglacial based on foraminiferal geochemistry
Climate during the Last Interglacial period (LIG, Marine Isotope Stage 5e) was on average warmer than the present, with a higher global sea level but also more unstable conditions. Today, the Baltic Sea interacts strongly with conditions in the North Atlantic region, and this interaction was likely even stronger during the LIG. We here present a reconstruction of seawater conditions during the LIG
Introduction to a Special Issue: Care and treatment for substance use disorders: Studies from around the world
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development
The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. Here, we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 tran
Significance, diagnosis and treatment of lateral lymph nodes in rectal cancer : A systematic review
Introduction: Patients with low rectal cancer are at risk for lateral lymph node metastasis (LLNM). Neoadjuvant chemoradiotherapy (CRT) is used to eradicate LLNM in the West, whereas in Japan the addition of lateral lymph node dissection (LLND) to total mesorectal excision (TME) is performed. A systematic review was conducted to assess incidence, location, risk factors and diagnosis of LLNM and la
China’s Belt and Road Initiative : Pragmatism over Morals?
Is China beating the US and EU through its pragmatic approach towards cooperation under the “Belt and Road” Initiative (“一带一路”倡议) (BRI)? Despite the advent of the US’ “Build Back Better World” (B3W) and the EU’s “Connecting Europe Globally” (CEG), evidence from Sri Lanka suggests that some countries still look to China for support due to the ‘no-strings-attached’ nature of its investments. The sta
Samtidens dårskap och förfall : om Livius och Hannibalkriget
En essä om Livius och kriget mot Hannibal utifrån Karin Westin Tikkanens översättning Hannibalkriget (Appell förlag), bok 21 och 22 av Livius historiska verk Ab urbe condita.
Experimental investigation of premixed ammonia combustion at high Karlovitz number conditions
This thesis aims to acquire deep knowledge on turbulent premixed combustion at high Karlovitz (Ka) number conditions with the help of laser-based diagnostic measurements.Considering that ammonia (NH3), as a carbon-free energy carrier, is a promising candidate for replacing conventional fossil fuels in the future, all the investigations in this work were carried out on ammonia/air premixed flames.
Strandängsfåglar : Rapport från Gemensamt delprogram täckande perioden 1988–2018
Populationstrender för fåglar på havsstrandängar i sju län analyserades för perioden 1988–2018. För 27 arter där en trend kunde beräknas för hela perioden var bestånden minskande för 13 arter, ökande för 8 arter och för 6 arter fanns ingen säker förändring. Vid analys för perioden 2003–2018 kunde trender beräknas för 38 arter och bestånden var minskande för 18 arter, ökande för 10 arter och oförän