Objectives: Inclusion body myositis is characterized by inflammatory and degenerative changes, but the temporal relation of these events is unknown. Materials and Methods: In nineteen patients with inclusion body myositis, muscle strength was correlated with inflammatory and degenerative findings on magnetic resonance imaging (MRI) and in muscle biopsies in three different muscles (tibialis anteri

Gasoline-fueled Partially Premixed Combustion is an advanced combustion concept approaching high efficiency as well as low emissions. The most challenging task on controlling a gasoline PPC engine is to regulate the maximum pressure rise rate to reduce engine noise and durability problem. A trade-off relationship between pressure rise rate and soot emissions is observed as a function of pilot inje

The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. S100A9 is a small molecule which has shown to have a role in the est

Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data (1992–2013) to conduct a population-based, case–control study. C

This paper presents a review of particle deposition research in film-cooled gas turbines based on the recent open literature. Factors affecting deposition capture efficiency and film cooling effectiveness are analyzed. Experimental studies are summarized into two discussions in actual and virtual deposition environments. For investigation in virtual deposition environments, available and reasonabl

Objective: To characterize sociodemographic differences in semen parameters among US men undergoing a semen analysis. Materials and Methods: Men who provided a semen sample were identified from insurance claims between 2007 and 2016. Differences in semen parameters were characterized according to age, race, education, and region. Mean semen parameters and proportions of men with suboptimal paramet

The non-uniform conditions and potential progression of fires in larger spaces calls for modelling methods extending outside of the traditional compartment fire framework. Even though a handful of studies in the area exist there is still little guidance available on how progressing fires in large enclosures can be modelled. Three different methods to calculate far-field gas temperature in large en

Terbinafine is used for the treatment of several superficial fungal infections. In silico analyses and animal models suggest that terbinafine might have an anti-tumor effect. We aimed to explore whether subsequent administration of terbinafine might be associated with a lower mortality rate in patients with prostate cancer. We identified patients diagnosed with prostate cancer between July 2005 an

Turbine blades operate under a harsh environmental condition, and the inlet temperature of gas turbines is increasing with requirement of high engine effi-ciency. Some cooling schemes are adopted to prevent these blades from the ther-mal erosion of the hot mainstream. Film cooling technology is used widely and effectively in gas turbines. The coolant air is suppressed to the wall by the main-strea

Volatile organic compounds (VOCs) in biological samples have gained popularity for disease monitoring and diagnosis. Celiac disease (CD) is one of the many prevalent health conditions which are challenging to diagnose. The aim of this study was to optimize a solid phase microextraction followed by gas chromatography-mass spectrometry, for quantitative analysis of a wide range of VOCs in the urine

Blockchain, the technology underlying bitcoin, is an emerging financial technology (FinTech) that is poised to have strategic impacts on organizations. Because it is a new phenomenon, there are few studies on blockchain, and those studies have focused mainly on the technology's potential impacts, whereas how to effectively implement it in an organization remains unknown. Our study intends to fill

Parliamentary debates provide an arena where Members of Parliament (MPs) present, challenge, or defend public policies. However, the “plenary bottleneck” allows the party leadership to decide who participates in a debate. We argue that in this decision the timing of a debate matters: in proximity of elections, the leadership should be concerned with maintaining its brand name and therefore restric

Nowadays, glass is increasingly being used as a load-bearing material for structural components in buildings and façades. Different structural member solutions (such as panels, beams, columns) and loading conditions were the subjects of several research studies in recent years. Most of them, however, were typically limited to experimental testing and numerical simulations on glass elements and ass

Objective: COOL AMI EU pilot was a multi-center, randomized controlled trial to assess feasibility and safety of rapid intravascular therapeutic hypothermia (TH) in conscious patients with anterior ST-elevation myocardial infarction (STEMI) undergoing primary PCI (PPCI). We report the effect of hypothermia upon microvascular obstruction (MVO). Methods: Conscious patients with anterior STEMI and sy

Purpose: To investigate the main concerns associated with being a parent of a child with cataract and how the parents deal with these concerns. Design and method: Twenty-three parents; 6 mothers, 5 fathers and 6 couples with a child with cataract were included in this study. The parents included some with a personal experience of cataract and some without. Data was collected through 17 in-depth in

Context. The abundance ratio N/O is a useful tool to study the interplay of galactic processes, for example star formation e ciency, timescale of infall, and outflow loading factor. Aims. We aim to trace log(N/O) versus [Fe/H] in the Milky Way and to compare this ratio with a set of chemical evolution models to understand the role of infall, outflow, and star formation e ciency in the building up

This paper assesses a discussion on how to understand the relationship between Husserl’s Cartesian way and the later ontological way to the transcendental reduction: Is the Cartesian way flawed to the extent that the ontological way constitutes a principal correction to it, or is the ontological way a logical completion of an insufficient but nonetheless necessary Cartesian way? A reading with the