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Background: Early metastatic spread represents a challenge in fighting small cell lung cancer (SCLC). The molecular mechanisms underlying metastatic dissemination remain unclear in this devastating disease. Methods: Invasive traits were investigated in 13 SCLC cell lines using 3D-spheroid formation, sprouting assays, co-cultures and a zebrafish xenograft model. Proteomic analysis was performed to
Objectives: Both depression and suicidal behaviour have been associated with neuroinflammation. Galectin-3 (Gal-3), a protein involved in microglial activation, has been linked to pro-inflammatory cytokines and the severity of depressive symptoms. The extent to which peripheral levels of Gal-3 reflect neuroinflammation is unknown, as is the relationship between Gal-3 and suicidality. Methods: Bloo
Background Anorexia nervosa is associated with high personal and financial costs for sufferers, carers and society in general, but little is known about the long-term health economic burden. Aims To examine healthcare utilisation, social assistance, sick leave and disability pension in individuals with anorexia nervosa over a period of 30 years. Method Fifty-one individuals with adolescent-onset a
Background and Aims: Metabolic dysfunction–associated steatotic liver disease (MASLD) is increasingly prevalent in aging populations. Dietary anthocyanin has been shown to exert metabolic benefits in aging and age-associated metabolic disorders. However, its role in protecting against age-dependent hepatic steatosis and the underlying mechanisms remain poorly defined.Approach and Results: In 18-mo
With the global economic transformation and the advancement of innovation-driven strategies, entrepreneurship education has become a crucial pathway for cultivating innovative talent, driving economic growth, and enhancing national competitiveness. It also provides new avenues for individual career development and societal value creation. This paper systematically analyzes the development trajecto
Protein degradation is a regulated process that reshapes the proteome and generates bioactive peptides. Peptidomics and degradomics enables large-scale measurement of these peptides, yet most data analyses approaches treat peptides as isolated endpoints rather than intermediates produced by sequential cleavage. Here, we introduce degradation graphs, a probabilistic framework that represents proteo
Background Virtual reality (VR) technology is increasingly being explored as a tool to help reduce aggressive behavior in forensic psychiatric settings. This study aimed to explore the experiences of therapists and ward staff participating in a pilot study of a VR-assisted aggression treatment within a Swedish maximum-security forensic psychiatric clinic.Methods A qualitative, descriptive, and exp
Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2 (SNAI2) is frequently amplified in prostate cancer, it is epigenetically silenced in this disease, with dynamic changes in SNAI2 levels showing distin
IMPORTANCE: Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer.OBJECTIVES: To identify clinical and molecular correlates of luminal and basal subtypes in metastatic castration-resistant prostate cancer (mCRPC) and investigate
We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, we describe an approach utilizing in vitro DNA and RNA sequencing and drug response data to create TreAtment Response Generalized Elastic-neT Signatures (TARGET
Detection of toxic hexavalent chromium in soil, groundwater, industrial effluent, etc., is of significant interest. We demonstrate the electrochemical detection of Cr(VI) using a surface-engineered mesoporous carbon-based material. The mesoporous carbon-based material is obtained by the controlled pyrolysis of a homogenous mixture of Fe and Co complexes of hydrolyzed collagen. The as-synthesized m
Thanks to superionic conductivity and compatibility with >4 V cathodes, halide solid electrolytes (SEs) have elicited tremendous interest for application in all-solid-state lithium batteries (ASSLBs). Many compositions based on groups 3, 13, and divalent metals, and substituted stoichiometries have been explored, some displaying requisite properties, but the Li+ conductivity still falls shor
Interfacial stability issues at the cathode remain a bottleneck to developing durable and high-power all-solid-state lithium batteries (ASSLBs). In fact, the presence of conductive carbon in the cathode, necessary for high capacity and power capability, is believed to aggravate the stability woes. Thus, it is typically excluded from the cathode mix. Herein, employing a model functionalized ca
H+ co-intercalation chemistry of the cathode is perceived to have damaging consequences on the low-rate and long-term cycling of aqueous zinc batteries, which is a critical hindrance to their promise for stationary storage applications. Herein, the thermodynamically competitive H+ storage chemistry of an attractive high-voltage cathode LiMn2O4 is revealed by employing operando and ex-situ anal
Advancement of aqueous zinc-ion batteries (AZIBs) for practical application is limited due to the inferior performance of the existing cathode. Herein, we demonstrate rational design and synthesis of an oxygen vacancy-rich low-valent vanadium-based spinel cathode (OV-ZnV2O4) for the fabrication of high-performance AZIBs. ZnV2O4 having an urchin-like morphology with nanorods ∼19 nm in diameter
Cathode–solid electrolyte (SE) interfacial stability issues pose a significant challenge to stable and high-power operations of all-solid-state batteries, which promise greater energy density, thermal stability, and safety than the current liquid electrolyte-based Li-ion technology. For technologically important Ni-rich NMCs (LiNixMnyCozO2 or NMCxyz; x/y/z: Ni/Mn/Co stoichiometry) with sulfid
